Results 181 to 190 of about 106,054 (214)

Glutaminolysis Blockade‐Empowered Bimodal Nanodepot for Spatially Complementary Sono‐Thermal Ablation via PANoptosis and STING Activation Against Large Tumors

Advanced Science, EarlyView.
An injectable bimodal TCPD nanodepot disrupts glutaminolysis and TCA metabolism, sensitizing large tumors to spatially complementary sono‐thermal ablation for complete treatment coverage. This intervention induces mitochondrial and endoplasmic reticulum dysfunction, genotoxicity, and NAD+ depletion, converging to trigger PANoptosome assembly and ...
Yi‐Ming Liu, Juan Qin, Si‐Yuan Wu, Xue‐Zhen Zhu, Yun‐Fei Cai, Pei‐Yao Sun, Hao Yang, Xing‐Yue Wang, Shu Li, Duo Wang, Hai‐Dong Zhu   +10 more
wiley   +1 more source

Epithelial CD155-TIGIT/CD226 signaling links CD8⁺ T-cell exhaustion to frequent exacerbations in COPD. [PDF]

Respir Res
Wang D, Li H, Zhao Z, Zhao J, Hai X, Fan Y, Ma W, Chen J, Ge X, Duan X, Hou J.   +10 more
europepmc   +1 more source

Molecular Landscapes of Tumor Dormancy in Gynecologic Malignancies: From Survival Mechanisms to Precision Interception

Advanced Science, EarlyView.
This Review outlines the biological framework of entry, maintenance, and awakening in dormant minimal residual disease across gynecologic cancers. By mapping critical biological dependencies—from metabolic plasticity to microenvironment interactions—it evaluates novel interception concepts and presents a translational framework combining single‐cell ...
Shih‐Hsuan Cheng, Ren‐Wang Peng, Chang‐Cheng Wu, Chi‐Wen Luo, Emmanuel Naveen Raj, Zhi‐Hong Wen, Tzu‐Hung Hsiao, Chia‐Jung Li   +7 more
wiley   +1 more source

Overcoming T cell exhaustion and senescence in CAR T cell therapy for solid tumors. [PDF]

Clin Transl Oncol
Pérez-Criado I, Figols M, Moya-Sevilla A, Bautista A, Gómez-Díaz D, Font A, Martin-Liberal J, Ruiz de Porras V.   +7 more
europepmc   +1 more source

Developing Metal–Polyphenol Network‐Based Single‐Protein Particle Encapsulation System for Sustained Release of Whey Protein to Mitigate Sarcopenia

Advanced Science, EarlyView.
Sarcopenia has emerged as a major health challenge in the aging population. Developing a sustained‐release system for whey protein may enhance its effectiveness in mitigating sarcopenia. Herein, a novel “single‐protein particle encapsulation” (SPPE) system is developed to protect whey protein and control its release.
Yafei Zhang, Yuning Zhang, Yongjian Ai, Yao Lu, Heng Quan, Zhen Zhang, Yuqi Wang, Yujia Luo, Xiaoxu Zhang, Yingying Lin, Sijia Song, Huiyuan Guo   +11 more
wiley   +1 more source

Development and validation of a novel T cell exhaustion-related signature to predict prognosis in patients with breast cancer. [PDF]

Discov Oncol
Guo L, Chen X, Zhou F.
europepmc   +1 more source

An ATP7A‐Mediated Endogenous Regulation Bio‐Clay Enzyme Enables Self‐Amplified Copper Accumulation for Immunogenic Pyrop

Advanced Science, EarlyView.
A self‐amplifying bio‐clay nanozyme (Bio‐Clayzyme) disrupts tumor metabolic homeostasis through endogenous copper transporter ATPase (ATP7A) downregulation, enhancing cascade catalysis and triggering immunogenic pyroptosis for effective tumor immunotherapy.
Weimin Xie, Yan Li, Guangyao Li, Ying Chen, Huaming Yang   +4 more
wiley   +1 more source

Altered OXPHOS potential in ascites immune cells is linked to CD4 T-cell exhaustion and a higher risk of spontaneous bacterial peritonitis in cirrhosis. [PDF]

Front Immunol
Cosgun HT, Kumar P, Zhang IW, Hammerich L, Sudheer V, Pavlidis C, Wang J, Schwarz H, Tacke F, Canbay A, Engelmann C.   +10 more
europepmc   +1 more source

Proteasome-guided haem signalling axis contributes to T cell exhaustion. [PDF]

Nature
Xu Y, Shangguan Y, Chuang YM, Chang TH, Liu W, Peng JJ, Garnica J, Xie L, Hsueh PC, Lin MC, Wang YH, Hajdu KL, Wu Y, Akrami M, Wang C, Kohl A, Zippelius A, Qi W, Wang M, Budiarto BR, Chen SY, Xiao Z, Vardaka P, Roychoudhuri R, Bai Z, Fan R, Carmona S, Yu YR, Scheiermann C, Wang J, Ho PC.   +30 more
europepmc   +1 more source