Results 61 to 70 of about 106,054 (214)

Bacteria‐Trained, MnO2‐Armored Dendritic Cells for Immunotherapy

Advanced Materials, EarlyView.
MnO2‐armored, bacteria‐trained dendritic cells undergo tumor‐responsive mechanical and immunological transformation. The nanocoating masks immune ligands and maintains a mechanically stiff, quiescent state during circulation, while the tumor microenvironment removes the armor and restores cellular deformability and immune accessibility.
Zhao Guo, Min Ge, Zesong Ruan, Tingwang Shi, Mahyar Mahmoudi, Soohwan An, Na Kong, Yunfeng Chen, Han Lin, Wei Tao   +9 more
wiley   +1 more source

Vitamin C‐Induced Photo‐Redox Threshold Enables High‐Fidelity Volumetric Printing of Collagen

Advanced Materials, EarlyView.
Tomographic volumetric printing (TVP) of native proteins is limited by uncontrolled background crosslinking. Here, vitamin C is introduced as a biocompatible redox regulator to establish a tunable nonlinear polymerization threshold response for TVP.
Bin Wang, Amelia Hasenauer, Kristian Ivkovic, Ann‐Sophie Frind, David Fercher, Marcy Zenobi‐Wong   +5 more
wiley   +1 more source

Molecular insight into T cell exhaustion in hepatocellular carcinoma

Pharmacological Research
Hepatocellular carcinoma is one of the leading causes of cancer-related mortality globally. The emergence of immunotherapy has been shown to be a promising therapeutic approach for hepatocellular carcinoma in recent years.
Yonghua Zhu, Huabing Tan, Jincheng Wang, Haiwen Zhuang, Huanbin Zhao, Xiaojie Lu   +5 more
doaj   +1 more source

Interface Engineering of Porous Transport Layer‐Catalyst Layer in Proton Exchange Membrane Water Electrolyzers: A Comprehensive Review

Advanced Materials Interfaces, EarlyView.
The PTL–CL interface plays a decisive role in PEMWE performance by governing electron conduction, water supply, oxygen removal, catalyst utilization, and interfacial stability. This review summarizes interface‐related resistance sources, characterization methods, and engineering strategies, highlighting rational PTL–CL interface design for low‐cost ...
Aobo Wan, Zhengkai Tu
wiley   +1 more source

Scalable Production of Disordered Nickel‐Iron‐Aluminum Oxides as Stable Anodes for Water Electrolysis: The Role of Aluminum

Advanced Materials Interfaces, EarlyView.
Solution precursor plasma spraying enables the scalable fabrication of porous and disordered nickel‐iron‐aluminum oxide coatings as precious‐metal‐free anodes. Aluminum inhibits crystal growth, optimizes local atomic sites, and enhances charge and ion transport to accelerate reaction kinetics, leading to excellent performance and operational stability.
Tugce Ustunel, Joakim Bäckström, Esdras J. Canto‐Aguilar, Mouna Rafei, Litty Thomas Manamel, Mahesh Ramakrishnan, Konstantin Klementiev, Nina Grunditz, Erik Zimmerman, Thomas Wågberg, Susanne Holmin, Eduardo Gracia‐Espino   +11 more
wiley   +1 more source

Disruption of IL-33 Signaling Limits Early CD8+ T Cell Effector Function Leading to Exhaustion in Murine Hemophagocytic Lymphohistiocytosis

Frontiers in Immunology, 2018
Danger signals mediated through ST2, the interleukin-33 (IL-33) receptor, amplify CD8+ T cell-mediated inflammation in the murine model of familial hemophagocytic lymphohistiocytosis type 2 (FHL2), and blockade of ST2 provides a potential therapeutic ...
Julia E. Rood, Julia E. Rood, Thomas N. Burn, Thomas N. Burn, Vanessa Neal, Niansheng Chu, Edward M. Behrens, Edward M. Behrens   +7 more
doaj   +1 more source

High Throughput Aerosol Jet Printing to Operationalize High Aspect Ratio Patterning

Advanced Materials Technologies, EarlyView.
High‐throughput aerosol jet printing poses distinct limiting mechanisms to the printing process. These include rapidly changing ink chemistries, atomization instabilities, and liquid‐phase spreading. The combination of in‐line heating, process monitoring, and traditional optimization procedures enables rapid printing of high‐aspect‐ratio structures ...
Bella I. Guyll, Md Mahdi Ul Ishtiaque, Md Ramjan Ali, Todd A. Kingston, Ethan B. Secor   +4 more
wiley   +1 more source

Robotic Assistants in the Operating Room: A Systematic Review of Vision‐Based Systems for Nonoperative Tasks

Advanced Robotics Research, EarlyView.
This review brings together 20 publications describing 11 robotic system families developed for instrument handling, sterile‐package opening, supply delivery, and operating room logistics. Perception is becoming more capable through deep learning and language‐guided control, but autonomy remains limited, evidence is largely laboratory‐based, and no ...
Eugenia Mawuenya Akpo, Pietro Falco, Nicholas Raison, Christos Bergeles, Letizia Gionfrida   +4 more
wiley   +1 more source

Sodium citrate pretreatment enhances CAR-T cell persistence and anti-tumor efficacy through inhibition of calcium signaling

Frontiers in Immunology
IntroductionChimeric antigen receptor T cell (CAR-T) therapy has shown success in treating hematological malignancies, but its effectiveness against solid tumors is hindered by T cell exhaustion.
Xuechen Yin, Wenwen Chen, Xudong Ao, Luxia Xu, Jiujiu Cao, Tinghui Huang, Junqing Liang, Jianhua Hu, Jiaqi Liu, Xinping Wang, Wenying Li, Muya Zhou, Lingfeng He, Zhigang Guo   +13 more
doaj   +1 more source

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

Advanced Science, EarlyView.
Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin, Saurabh Singh, Soumya Chatterjee, Guang‐Zhi Sui, Yi‐Fu Wang, Ya‐Ting Lu, Yu‐Ling Lee, Kun‐Yuan Lin, Joy Khag, Ta‐Yu Liu, Shao‐Han Chang, Wai‐Mui Cheung, Hsiao‐Chin Hong, Ren‐Jun Hsu, Chen‐Yang Shen, Chia‐Wei Li, Weng‐Lang Yang, Yao‐Ming Chang, Shih‐Yu Chen, Chandan Guha, Shu‐Ping Wang   +20 more
wiley   +1 more source