Results 81 to 90 of about 95,123 (301)

A Bifunctional T3SS‐Effector Simultaneously Cleaves Host MAP Kinase and Inhibits PPM1A Phosphatase

Advanced Science, EarlyView.
Pathogenic bacteria exploit the metalloprotease effector NleD to subvert host defenses. Structural, biochemical, and infection analyses reveal a bifunctional mechanism by which NleD binds and inhibits the host phosphatase PPM1A while preserving its proteolytic activity against MAPKs.
Yaakov Socol, Lihi Gur‐Arie, Netanel Tzarum, Tamara Wellins, Naama Katsowich, Miriam Ravins, Michal Bejerano‐Sagie, Klil Cohen, Oded Livnah, Joshua N. Adkins, Ernesto Nakayasu, Alexei Savchenko, Yeu Khai Choong, Nikhil Kumar Tulsian, Saturo Machida, Sigal Ben‐Yehuda, Yael Litvak, J. Sivaraman, Ilan Rosenshine   +18 more
wiley   +1 more source

Restricted T cell receptor repertoire in CLL-like monoclonal B cell lymphocytosis and early stage CLL

OncoImmunology, 2018
Analysis of the T cell receptor (TR) repertoire of chronic lymphocytic leukemia-like monoclonal B cell lymphocytosis (CLL-like MBL) and early stage CLL is relevant for understanding the dynamic interaction of expanded B cell clones with bystander T cells.
Gonzalo Blanco, Anna Vardi, Anna Puiggros, Andrea Gómez-Llonín, Manuel Muro, María Rodríguez-Rivera, Evangelia Stalika, Eugenia Abella, Eva Gimeno, Manuela López-Sánchez, Alicia Senín, Xavier Calvo, Pau Abrisqueta, Francesc Bosch, Ana Ferrer, Kostas Stamatopoulos, Blanca Espinet   +16 more
doaj   +1 more source

Impact of cellular lifespan on the T cell receptor repertoire [PDF]

European Journal of Immunology, 2007
AbstractPro‐survival members of the Bcl‐2 family are potent inhibitors of cell death and determine the lifespan of immature thymocytes by counteracting the intrinsically active apoptotic program in these cells. BH3‐only proteins are potent antagonists of Bcl‐2‐like molecules and regulate death and survival of lymphocytes during their development and ...
Abdelbasset, Hamrouni, Anna, Olsson, G Jan, Wiegers, Andreas, Villunger   +3 more
openaire   +2 more sources

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Stable global repertoire architecture masks short-term clonal remodeling in intratumoral TCR repertoires

Frontiers in Immunology
BackgroundTumor-infiltrating T cell receptor repertoires are increasingly profiled to assess intratumoral T cell dynamics and inform prognosis and treatment response.
Pernille G. Pedersen, Odd L. Gammelgaard, Sofie Traynor, Christina H. Ruhlmann, Christina H. Ruhlmann, Aida S. Hansen, Henrik J. Ditzel, Henrik J. Ditzel, Henrik J. Ditzel, Morten F. Gjerstorff, Mikkel G. Terp   +10 more
doaj   +1 more source

Priming of CD8+ T cell responses following immunization with heat-killed Plasmodium sporozoites.

, 2006
Protective immune responses against malaria are induced by immunization with radiation-attenuated Plasmodium sporozoites. In contrast, non-viable, heat-killed sporozoites do not induce protection, emphasizing the requirement for live parasites to achieve
Morrot, Alexandre, Rai, Urvashi, Alexandre Morrot, Fidel Zavala, Hafalla, Julius CR, Rodriguez, Ana, Ana Rodriguez, Zavala, Fidel, Urvashi Rai, Dabeiba Bernal-Rubio, Bernal-Rubio, Dabeiba, Julius C. R. Hafalla   +11 more
core   +1 more source

A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity

Advanced Science, EarlyView.
This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu, Xinyu Sun, Wanxia Ma, Jianming Yang, Xuan Sun, Lisong Zhang, Yumeng Liu, Tianshu Ren, Qi Wang, Jingyu Wang, Xiao Li, Xianping Peng, Liu Yang, Junqiang Lv, Zhi Yao, Zhi‐Song Zhang, Quan Wang   +16 more
wiley   +1 more source

Characterization of T-cell receptor loci and expressed repertoire reveals a capacity for robust T-cell response in Atlantic cod (Gadus morhua)

Scientific Reports
The Atlantic cod presents a peculiar case in fish immunology, due to the loss of MHCII and CD4 genes. Despite the absent antibody response to T cell-dependent antigens, it is a prolific species.
Ádám Györkei, Finn-Eirik Johansen, Shuo-Wang Qiao   +2 more
doaj   +1 more source

Next-Generation Sequencing Analysis of the Human TCRγδ+ T-Cell Repertoire Reveals Shifts in Vγ- and Vδ-Usage in Memory Populations upon Aging

Frontiers in Immunology, 2018
Immunological aging remodels the immune system at several levels. This has been documented in particular for the T-cell receptor (TCR)αβ+ T-cell compartment, showing reduced naive T-cell outputs and an accumulation of terminally differentiated clonally ...
Martine J. Kallemeijn, François G. Kavelaars, Michèle Y. van der Klift, Ingrid L. M. Wolvers-Tettero, Peter J. M. Valk, Jacques J. M. van Dongen, Anton W. Langerak   +6 more
doaj   +1 more source

A Keratinocyte‐Mast Cell NF‐κB2/CXCL2/IL‐6 Amplification Loop Enhances Cutaneous Antifungal Defense Against C. albicans

Advanced Science, EarlyView.
ABSTRACT Mast cells (MCs), key innate immune sentinels at the host–environment interface, serve as primary responders to invading pathogens. However, their specific contribution to host defense against cutaneous Candida albicans (C. albicans) infection and their synergy with other immune and non‐immune cells remain poorly understood. Here, we show that
Yan Yuan, Manyun Mao, Jiaan Zhang, Zhimin Duan, JiaNing Wang, Yujie Chen, Sihan Chen, Chuting Liang, Xvyue Zhou, Songmei Geng, Min Li, Xu Chen, Ni Lian   +12 more
wiley   +1 more source