Results 91 to 100 of about 95,123 (301)

Multivariate analysis using high definition flow cytometry reveals distinct T cell repertoires between the foetal-maternal interface and the peripheral blood

Frontiers in Immunology, 2014
The human T-cell compartment is a complex system and while some information is known on repertoire composition and dynamics in the peripheral blood, little is known on repertoire composition at different anatomical sites.
Michelle eNeller, Brigittie eSantner-Nanan, Rebekah eBrennan, Peter eHsu, Steven eJoung, Ralph eNanan, Scott eBurrows, John J Miles   +7 more
doaj   +1 more source

T cell receptor repertoire of T cells in the kidneys of patients with lupus nephritis [PDF]

Arthritis & Rheumatism, 2002
AbstractObjectiveTo determine the role of T cells in the pathogenesis of lupus nephritis (LN).MethodsRenal biopsy specimens from 12 patients with systemic lupus erythematosus were used for the experiments. We analyzed T cell receptor (TCR) Vβ1–20 family genes on intrarenal T cells and on peripheral blood lymphocytes (PBLs) by nested reverse ...
Hideyuki, Murata, Ryutaro, Matsumura, Akio, Koyama, Takao, Sugiyama, Makoto, Sueishi, Kazuko, Shibuya, Akito, Tsutsumi, Takayuki, Sumida   +7 more
openaire   +2 more sources

Ecological Adaptation Mechanisms Underlying Successful Plant Reproduction

Advanced Science, EarlyView.
During floral induction, various environmental and endogenous signals converge to regulate the florigen protein, which is transported from leaves to the SAM to initiate flowering. Within the SAM, a complex network of receptor kinases and small peptides orchestrates floral development with high spatiotemporal precision.
Hang Zhao, Shenghui Huo, Yue Xing, Shuxin Zhang, Guilin Li, Yihui Liu, Chongyang Jin, Fuguang Li, Xiaoyang Ge   +8 more
wiley   +1 more source

powerTCR: A model-based approach to comparative analysis of the clone size distribution of the T cell receptor repertoire.

PLoS Computational Biology, 2018
Sequencing of the T cell receptor (TCR) repertoire is a powerful tool for deeper study of immune response, but the unique structure of this type of data makes its meaningful quantification challenging.
Hillary Koch, Dmytro Starenki, Sara J Cooper, Richard M Myers, Qunhua Li   +4 more
doaj   +1 more source

Swift development of protective effector functions in naive CD8(+) T cells against malaria liver stages. [PDF]

, 2001
We generated T cell receptor transgenic mice specific for the liver stages of the rodent malaria parasite Plasmodium yoelii and studied the early events in the development of in vivo effector functions in antigen-specific CD8(+) T cells.
Lafaille, JJ, Gen-ichiro Sano, Alexandre Morrot, Abe, R, Juan J. Lafaille, Fidel Zavala, Sano, G, Ryo Abe, Julius C.R. Hafalla, Hafalla, JC, Morrot, A, Zavala, F   +11 more
core   +1 more source

HNRNPD Induces Radioresistance in Nasopharyngeal Carcinoma by Sequestering GRAMD4 mRNA in Stress Granules

Advanced Science, EarlyView.
HNRNPD promotes radioresistance in nasopharyngeal carcinoma by enhancing stress granule assembly and sequestering GRAMD4 mRNA. This suppresses GRAMD4 translation and inhibits mitochondrial apoptosis. Targeting the integrated stress response with ISRIB restores GRAMD4 expression and sensitizes tumors to radiotherapy, revealing a translational control ...
Yingzi Li, Tong Xiang, Yuanyuan Liu, Desheng Weng, Jingjing Zhao, Hao Chen, Yan Tang, Songzuo Xie, Hao Zhang, Jun Luo, Xinyi Yang, Qiuzhong Pan, Muping Di, Jianchuan Xia   +13 more
wiley   +1 more source

Cuproptosis and Mitophagy Mediated by the THUMPD1/IGF2R‐Dependent Suppression of AKT and Activation of AMPK Signaling Suppress Lung Adenocarcinoma Progression

Advanced Science, EarlyView.
THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu, Bo Qin, Zhuoyu Gu, Weizheng Ding, Xiaoming Chen, Kaishang Zhang, Yujin Qiao, Shuang Yuan, Song Zhao, Xiangnan Li, Peng Zhang   +10 more
wiley   +1 more source

Deep Sequencing of the T-cell Receptor Repertoire Demonstrates Polyclonal T-cell Infiltrates in Psoriasis [version 1; referees: 2 approved]

F1000Research, 2015
It is well known that infiltration of pathogenic T-cells plays an important role in psoriasis pathogenesis. However, the antigen specificity of these activated T-cells is relatively unknown.
Jamie L. Harden, David Hamm, Nicholas Gulati, Michelle A. Lowes, James G. Krueger   +4 more
doaj   +1 more source

Regulatory T‐cells: receptors, repertoires and roles in disease [PDF]

Immunology, 2018
SummaryIn the 20‐or‐so years that immunologists have spent describing the mechanisms and functions of regulatory T‐cells, a very great deal has been learnt: a T‐cell subset once described for the generic ability to harness autoimmunity in vivo or diminish T‐cell proliferation in vitro is now appreciated to act on a plethora of cellular pathways using a
openaire   +2 more sources

A Kinetic Window Constricts the T Cell Receptor Repertoire in the Thymus

, 2001
To characterize the ligand binding properties of a naive T cell repertoire capable of responding to a foreign antigen, we analyzed T cell populations from T cell receptor (TCR) β transgenic mice using a novel, single cell peptide/major histocompatibility
Savage, Peter A., Davis, Mark M.
core   +1 more source