Results 61 to 70 of about 56,239 (298)

Quantifying selection in immune receptor repertoires

, 2014
The efficient recognition of pathogens by the adaptive immune system relies on the diversity of receptors displayed at the surface of immune cells. T-cell receptor diversity results from an initial random DNA editing process, called VDJ recombination ...
Callan Jr., Curtis G., Elhanati, Yuval, Mora, Thierry, Murugan, Anand, Walczak, Aleksandra M.   +4 more
core   +1 more source

Characteristics of tumor infiltrating lymphocyte and circulating lymphocyte repertoires in pancreatic cancer by the sequencing of T cell receptors [PDF]

, 2015
Pancreatic cancer has a poor prognosis and few effective treatments. The failure of treatment is partially due to the high heterogeneity of cancer cells within the tumor.
Bai, Xueli, Cai, Zhiming, He, Fusheng, Liang, Tingbo, Lou, Yu, Wang, Mingbang, Wei, Tao, Wu, Song, Yang, Jiaqi, Zhang, Qi, Zhang, Xiaoyu   +10 more
core   +2 more sources

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Predicting the spectrum of TCR repertoire sharing with a data-driven model of recombination

, 2018
Despite the extreme diversity of T cell repertoires, many identical T-cell receptor (TCR) sequences are found in a large number of individual mice and humans.
Callan Jr., Curtis G., Elhanati, Yuval, Mora, Thierry, Sethna, Zachary, Walczak, Aleksandra M.   +4 more
core   +1 more source

Development of bipedal and quadrupedal locomotion in humans from a dynamical systems perspective [PDF]

, 2012
The first phase in the development 0f locomotion, pr,öary variability would occur in normal fetuses and infants, and those with Uner Tan syndrome. The neural networks for quadrupedal locomotion have apparently been transmitted epigenetically through many
Tan, Prof. Dr. Uner
core   +2 more sources

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction [PDF]

, 2014
Babesia spp. are tick-borne, intraerythrocytic hemoparasites that use antigenic variation to resist host immunity, through sequential modification of the parasite-derived variant erythrocyte surface antigen (VESA) expressed on the infected red blood cell
Allred, David R., Berriman, Matt, Darby, Alistair, Echaide, Ignacio Eduardo, Farber, Marisa, Gahlot, Sunayna, Gamble, John, Gupta, Diness, Gupta, Yask, Hall, Neil, Jackson, Andrew P., Jackson, Louise, Lingelbach, Klaus, Malandrin, Laurence, Malas, Tareq B., Moussa, Ehab, Nair, Mridul, Otto, Thomas D., Pain, Arnab, Quail, Mike A., Ramaprasad, Abhinay, Reid, Adam J., Sanders, Mandy, Sharma, Jyotsna, Shiels, Brian, Tait, Andy, Tracey, Alan, Wastling, Jonathan M., Weir, William, Willadsen, Peter, Xia, Dong   +30 more
core   +6 more sources

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Mother and child T cell receptor repertoires: deep profiling study

Frontiers in Immunology, 2013
The relationship between maternal and child immunity has been actively studied in the context of complications during pregnancy, autoimmune diseases, and haploidentical transplantation of hematopoietic stem cells (HSC) and solid organs. Here, we have for
Ekaterina V Putintseva, Olga V Britanova, Dmitriy B Staroverov, Ekaterina M Merzlyak, Maria A Turchaninova, M eShugay, Dmitriy A Bolotin, Mikhail V Pogorelyy, Ilgar Z Mamedov, Vlasta eBobrynina, Mikhail eMaschan, Yuri B Lebedev, Dmitriy M Chudakov, Dmitriy M Chudakov   +13 more
doaj   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source