Results 41 to 50 of about 56,239 (298)

Inferring processes underlying B-cell repertoire diversity

, 2015
We quantify the VDJ recombination and somatic hypermutation processes in human B-cells using probabilistic inference methods on high-throughput DNA sequence repertoires of human B-cell receptor heavy chains.
Aleksandra M. Walczak, Curtis G. Callan, Dunn-Walters DK, Janeway C, Quentin Marcou, Shapiro GS, Shiokawa S, Stryer L, Thierry Mora, Yuval Elhanati, Zachary Sethna   +10 more
core   +1 more source

A Haystack Heuristic for Autoimmune Disease Biomarker Discovery Using Next-Gen Immune Repertoire Sequencing Data. [PDF]

, 2017
Large-scale DNA sequencing of immunological repertoires offers an opportunity for the discovery of novel biomarkers for autoimmune disease. Available bioinformatics techniques however, are not adequately suited for elucidating possible biomarker ...
Apeltsin, Leonard, Sirota, Marina, von Büdingen, H-Christian, Wang, Shengzhi   +3 more
core   +1 more source

Tiling solutions for optimal biological sensing [PDF]

, 2015
Biological systems, from cells to organisms, must respond to the ever changing environment in order to survive and function. This is not a simple task given the often random nature of the signals they receive, as well as the intrinsically stochastic ...
Walczak, Aleksandra M.
core   +2 more sources

Combination immunotherapy induces distinct T-cell repertoire responses when administered to patients with different malignancies. [PDF]

, 2020
BackgroundCTLA-4 blockade with ipilimumab is Food and Drug Administration-approved for melanoma as a monotherapy and has been shown to modulate the circulating T-cell repertoire.
Cham, Jason, Fong, Grant, Fong, Lawrence, He, Tao, Kwek, Serena, Oh, David Y, Paciorek, Alan, Zhang, Li   +7 more
core   +1 more source

Preparing unbiased T cell receptor and antibody cDNA libraries for the deep next generation sequencing profiling

Frontiers in Immunology, 2013
High-throughput sequencing has the power to reveal the nature of adaptive immunity as represented by the full complexity of T cell receptor (TCR) and antibody (IG) repertoires, but is at present severely compromised by the quantitative bias, bottlenecks,
Ilgar Z Mamedov, Ilgar Z Mamedov, Olga V Britanova, Ivan V Zvyagin, Ivan V Zvyagin, Maria A Turchaninova, Dmitriy A Bolotin, Ekaterina V Putintseva, Yuriy B Lebedev, Dmitriy M Chudakov, Dmitriy M Chudakov   +10 more
doaj   +1 more source

Computational strategies for dissecting the high-dimensional complexity of adaptive immune repertoires

, 2017
The adaptive immune system recognizes antigens via an immense array of antigen-binding antibodies and T-cell receptors, the immune repertoire. The interrogation of immune repertoires is of high relevance for understanding the adaptive immune response in ...
Afzal, Ahmed, Albert, Amanna, Andrews, Angermueller, Apeltsin, Arden, Atchley, Avnir, Barabási, Barak, Bashford-Rogers, Bastian, Baum, Becattini, Ben-Hamo, Berger, Betz, Boc, Bolen, Bolkhovskaya, Bolotin, Bouckaert, Boyd, Boyd, Breden, Brown, Burnet, Bürckert, Calis, Castro, Chang, Chao, Chen, Ching, Cobey, Collins, Corcoran, Covacu, Csardi, Cui, Dash, de Bourcy, DeKosky, DeKosky, DeWitt, Dziubianau, Elhanati, Elhanati, Elhanati, Ellebedy, Emerson, Felsenstein, Friedensohn, Gadala-Maria, Galson, Galson, Geering, Georgiou, Ghraichy, Giribet, Giudicelli, Glanville, Glanville, Glanville, Good, Granato, Greiff, Greiff, Greiff, Greiff, Greiff, Grigaityte, Guindon, Gupta, Gupta, Hagberg, Halliley, Hammarlund, Heather, Hershberg, Hochreiter, Hoehn, Hoehn, Hoehn, Horns, Howie, Iversen, Jackson, Janeway, Jiang, Johnston, Jost, Jurtz, Kaplinsky, Kaplinsky, Kendall, Khavrutskii, Kidd, Kidd, Kidera, Kirik, Konishi, Kumar, Landsverk, Larkin, Lavinder, Laydon, Laydon, Lee, Lee, Lewitus, Li, Lindeman, Lindner, Liu, Love, Lozupone, Madi, Madi, Malissen, Mamoshina, Mangul, Manz, Martin, Meng, Miho, Mora, Morisita, Murugan, Nazarov, Nouri, Oakes, Ostmeyer, Paradis, Parameswaran, Parola, Pinheiro, Pollok, Ralph, Ravn, Reddy, Rempala, Rempala, Revell, Rizzetto, Robinson, Ronquist, Roybal, Rubelt, Rubelt, Safonova, Schliep, Schramm, Schwab, Shannon, Sheng, Sheng, Shlemov, Shugay, Shugay, Shugay, Snir, Snir, Stamatakis, Stern, Strauli, Stubbington, Stubbington, Sun, Sun Cinelli, Swofford, Thomas, Tickotsky, Tonegawa, Torkamani, Trepel, VanDuijn, Venturi, Venturi, Vieira, Vita, Wang, Wardemann, Warren, Watson, Watson, Watson, Weinstein, Wine, Wine, Wu, Yaari, Yaari, Yang, Yeap, Yermanos, Yokota, Yu, Zhu   +200 more
core   +1 more source

The immune system and other cognitive systems [PDF]

, 2001
In the following pages we propose a theory on cognitive systems and the common strategies of perception, which are at the basis of their function. We demonstrate that these strategies are easily seen to be in place in known cognitive systems such as ...
Efroni, Sol, Hershberg, Uri
core   +1 more source

Statistical inference of the generation probability of T-cell receptors from sequence repertoires

, 2012
Stochastic rearrangement of germline DNA by VDJ recombination is at the origin of immune system diversity. This process is implemented via a series of stochastic molecular events involving gene choices and random nucleotide insertions between, and ...
A. M. Walczak, A. Murugan, Arstila, Blum, C. G. Callan, Cabaniols, Gauss, Lafaille, Lieber, Lieber, Mason, Monod, Robins, Schatz, T. Mora, Venturi, Verkaik, Wang, Weinstein   +18 more
core   +1 more source

Antigen receptor variable region repertoires expressed by T cells infiltrating thyroid, retroorbital, and pretibial tissue in Graves' disease [PDF]

, 1996
To date, it has remained unclear whether T cells infiltrating thyroid, retroorbital, and pretibial tissue of patients with Graves' ophthalmopathy and pretibial dermopathy represent a primary immune response that is directed against certain antigenic ...
Heufelder, Armin E., Scriba, Peter C., Wenzel, Björn E.   +2 more
core   +1 more source

Sampling from T Cell Receptor Repertoires [PDF]

, 2017
Modern single-cell sequencing techniques allow the unique TCR signature of each of a sample of hundreds of T cells to be read. The mathematical challenge is to extrapolate from the properties of a sample to those of the whole repertoire of an individual, made up of many millions of T cells.
Ferrarini, M, Molina-Paris, C, Lythe, G
openaire   +2 more sources