Results 51 to 60 of about 56,239 (298)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Self-Determination in the T Cell Repertoire [PDF]

Immunity, 2015
The number of T cells specific for various antigens can vary dramatically. In this issue of Immunity, Nelson et al. (2015) report that these differences might be, at least in part, set by the number of cross-reactive self peptides encountered by T cells during development.
Birnbaum, Michael E., Garcia, K. Christopher   +1 more
openaire   +2 more sources

Identification of novel STAT5B mutations and characterization of TCRβ signatures in CD4+ T-cell large granular lymphocyte leukemia

Blood Cancer Journal, 2022
CD4+ T-cell large granular lymphocyte leukemia (T-LGLL) is a rare subtype of T-LGLL with unknown etiology. In this study, we molecularly characterized a cohort of patients (n = 35) by studying their T-cell receptor (TCR) repertoire and the presence of ...
Dipabarna Bhattacharya, Antonella Teramo, Vanessa Rebecca Gasparini, Jani Huuhtanen, Daehong Kim, Jason Theodoropoulos, Gianluca Schiavoni, Gregorio Barilà, Cristina Vicenzetto, Giulia Calabretto, Monica Facco, Toru Kawakami, Hideyuki Nakazawa, Brunangelo Falini, Enrico Tiacci, Fumihiro Ishida, Gianpietro Semenzato, Tiina Kelkka, Renato Zambello, Satu Mustjoki   +19 more
doaj   +1 more source

T Cell Repertoire Alterations of Vascularized Xenografts

The Journal of Immunology, 1999
Abstract The role of T cells in the rejection of vascularized xenografts has been little explored. Because of the high potential diversity of xenoantigens, it has been suggested that xenotransplantation could induce a strong cellular response that could contribute to delayed rejection. Alternatively, alterations in molecular interactions
Brouard, Sophie, Vanhove, Bernard, Gagne, Katia, Neumann, Avidan, Douillard, Patrice, Moreau, Anne, Cuturi, Cristina, Soulillou, Jean Paul   +7 more
openaire   +3 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

A Comprehensive Analysis of the T and B Lymphocytes Repertoire Shaped by HIV Vaccines

Frontiers in Immunology, 2018
The exploitation of various human immunodeficiency virus type-1 (HIV-1) vaccines has posed great challenges for the researchers in precisely evaluating the vaccine-induced immune responses, however, the understanding of vaccination response suffers from ...
Longlong Wang, Longlong Wang, Longlong Wang, Wei Zhang, Wei Zhang, Liya Lin, Liya Lin, Xiao Li, Xiao Li, Nitin K. Saksena, Nitin K. Saksena, Jinghua Wu, Jinghua Wu, Shiyu Wang, Shiyu Wang, Shiyu Wang, Joseph G. Joyce, Xiuqing Zhang, Xiuqing Zhang, Huanming Yang, Huanming Yang, Jian Wang, Jian Wang, I-Ming Wang, Xiao Liu, Xiao Liu   +25 more
doaj   +1 more source

The Shaping of the T Cell Repertoire [PDF]

Immunity, 2001
By combining a TCRbeta transgene with a TCRalpha minilocus comprised of a single V and two J gene segments, we engineered a mouse line exhibiting ample but focused TCR diversity, restricted to CDR3alpha. Using single-cell PCR and high-throughput sequencing, we have exploited this system to scrutinize T cell repertoire selection and evolution.
Correia-Neves, Margarida, Waltzinger, Caroline, Mathis, Diane, Benoist, Christophe   +3 more
openaire   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Breast cancer is marked by specific, Public T-cell receptor CDR3 regions shared by mice and humans.

PLoS Computational Biology, 2021
The partial success of tumor immunotherapy induced by checkpoint blockade, which is not antigen-specific, suggests that the immune system of some patients contain antigen receptors able to specifically identify tumor cells.
Miri Gordin, Hagit Philip, Alona Zilberberg, Moriah Gidoni, Raanan Margalit, Christopher Clouser, Kristofor Adams, Francois Vigneault, Irun R Cohen, Gur Yaari, Sol Efroni   +10 more
doaj   +1 more source

A Framework to Identify Antigen-Expanded T Cell Receptor Clusters Within Complex Repertoires

Frontiers in Immunology, 2021
Common approaches for monitoring T cell responses are limited in their multiplexity and sensitivity. In contrast, deep sequencing of the T Cell Receptor (TCR) repertoire provides a global view that is limited only in terms of theoretical sensitivity due ...
Valentina Ceglia, Valentina Ceglia, Valentina Ceglia, Erin J. Kelley, Annalee S. Boyle, Sandra Zurawski, Sandra Zurawski, Heather L. Mead, Caroline E. Harms, Jean-Philippe Blanck, Anne-Laure Flamar, Anne-Laure Flamar, Anne-Laure Flamar, Jung Hwa Kirschman, Paul Ogongo, Joel D. Ernst, Yves Levy, Yves Levy, Gerard Zurawski, Gerard Zurawski, John A. Altin   +20 more
doaj   +1 more source