Results 31 to 40 of about 56,239 (298)

Human T cell receptor occurrence patterns encode immune history, genetic background, and receptor specificity

eLife, 2018
The T cell receptor (TCR) repertoire encodes immune exposure history through the dynamic formation of immunological memory. Statistical analysis of repertoire sequencing data has the potential to decode disease associations from large cohorts with ...
William S DeWitt III, Anajane Smith, Gary Schoch, John A Hansen, Frederick A Matsen IV, Philip Bradley   +5 more
doaj   +1 more source

Identification of antigen-specific TCR sequences based on biological and statistical enrichment in unselected individuals

JCI Insight, 2021
Recent advances in high-throughput T cell receptor (TCR) sequencing have allowed for new insights into the human TCR repertoire. However, methods for capturing antigen-specific repertoires remain an area of development.
Neal P. Smith, Bert Ruiter, Yamini V. Virkud, Ang A. Tu, Brinda Monian, James J. Moon, J. Christopher Love, Wayne G. Shreffler   +7 more
doaj   +1 more source

T cell repertoire breadth is associated with the number of acute respiratory infections in the LoewenKIDS birth cohort

Scientific Reports, 2023
We set out to gain insight into peripheral blood B and T cell repertoires from 120 infants of the LoewenKIDS birth cohort to investigate potential determinants of early life respiratory infections.
Lisa Paschold, Cornelia Gottschick, Susan Langer, Bianca Klee, Sophie Diexer, Ivona Aksentijevich, Christoph Schultheiß, Oliver Purschke, Peggy Riese, Stephanie Trittel, Roland Haase, Frank Dressler, Wolfgang Eberl, Johannes Hübner, Till Strowig, Carlos A. Guzman, Rafael Mikolajczyk, Mascha Binder   +17 more
doaj   +1 more source

Single-Cell Approach to Influenza-Specific CD8+ T Cell Receptor Repertoires Across Different Age Groups, Tissues, and Following Influenza Virus Infection

Frontiers in Immunology, 2018
CD8+ T cells recognizing antigenic peptides derived from conserved internal viral proteins confer broad protection against distinct influenza viruses.
Sneha Sant, Ludivine Grzelak, Ludivine Grzelak, Zhongfang Wang, Angela Pizzolla, Marios Koutsakos, Jane Crowe, Thomas Loudovaris, Stuart I. Mannering, Glen P. Westall, Linda M. Wakim, Jamie Rossjohn, Jamie Rossjohn, Jamie Rossjohn, Stephanie Gras, Stephanie Gras, Michael Richards, Jianqing Xu, Paul G. Thomas, Liyen Loh, Thi H. O. Nguyen, Katherine Kedzierska   +21 more
doaj   +1 more source

Detection of Enriched T Cell Epitope Specificity in Full T Cell Receptor Sequence Repertoires

Frontiers in Immunology, 2019
High-throughput T cell receptor (TCR) sequencing allows the characterization of an individual's TCR repertoire and directly queries their immune state. However, it remains a non-trivial task to couple these sequenced TCRs to their antigenic targets.
Sofie Gielis, Sofie Gielis, Sofie Gielis, Pieter Moris, Pieter Moris, Wout Bittremieux, Wout Bittremieux, Wout Bittremieux, Nicolas De Neuter, Nicolas De Neuter, Nicolas De Neuter, Benson Ogunjimi, Benson Ogunjimi, Benson Ogunjimi, Benson Ogunjimi, Kris Laukens, Kris Laukens, Kris Laukens, Pieter Meysman, Pieter Meysman, Pieter Meysman   +20 more
doaj   +1 more source

Thymus-derived regulatory T cells control tolerance to commensal microbiota [PDF]

, 2014
Peripheral mechanisms preventing autoimmunity and maintaining tolerance to commensal microbiota involve CD4+Foxp3+ regulatory T cells1,2 generated in the thymus (tTregs) or extrathymically by induction of naive CD4+Foxp3− T cells (iTregs).
Bry, Lynn, Cebula, Anna, Denning, Timothy L., Ignatowicz, Leszek, Kisielow, Pawel, Kraj, Piotr, McIndoe, Richard A., Pabla, Simarjot Singh, Rempala, Grzegorz A., Seweryn, Michal   +9 more
core   +1 more source

SELECTION OF THE T CELL REPERTOIRE

Annual Review of Immunology, 1999
▪ Abstract  Advances in gene technology have allowed the manipulation of molecular interactions that shape the T cell repertoire. Although recognized as fundamental aspects of T lymphocyte development, only recently have the mechanisms governing positive and negative selection been examined at a molecular level.
Sebzda, E, Mariathasan, S, Ohteki, T, Jones, R, Bachmann, M, Ohashi, P   +5 more
openaire   +3 more sources

VDJtools: Unifying Post-analysis of T Cell Receptor Repertoires.

PLoS Computational Biology, 2015
Despite the growing number of immune repertoire sequencing studies, the field still lacks software for analysis and comprehension of this high-dimensional data.
Mikhail Shugay, Dmitriy V Bagaev, Maria A Turchaninova, Dmitriy A Bolotin, Olga V Britanova, Ekaterina V Putintseva, Mikhail V Pogorelyy, Vadim I Nazarov, Ivan V Zvyagin, Vitalina I Kirgizova, Kirill I Kirgizov, Elena V Skorobogatova, Dmitriy M Chudakov   +12 more
doaj   +1 more source

TCRβ Sequencing Reveals Spatial and Temporal Evolution of Clonal CD4 T Cell Responses in a Breach of Tolerance Model of Inflammatory Arthritis

Frontiers in Immunology, 2021
Effective tolerogenic intervention in Rheumatoid Arthritis (RA) will rely upon understanding the evolution of articular antigen specific CD4 T cell responses. TCR clonality of endogenous CD4 T cell infiltrates in early inflammatory arthritis was assessed
Shaima Al Khabouri, Robert A. Benson, Catriona T. Prendergast, Joshua I. Gray, Thomas D. Otto, James M. Brewer, Paul Garside   +6 more
doaj   +1 more source

Naïve Regulatory T Cell Subset Is Altered in X-Linked Agammaglobulinemia

Frontiers in Immunology, 2021
The interplay between T- and B-cell compartments during naïve, effector and memory T cell maturation is critical for a balanced immune response. Primary B-cell immunodeficiency arising from X-linked agammaglobulinemia (XLA) offers a model to explore B ...
Pavel V. Shelyakin, Ksenia R. Lupyr, Ksenia R. Lupyr, Evgeny S. Egorov, Ilya A. Kofiadi, Dmitriy B. Staroverov, Dmitriy B. Staroverov, Sofya A. Kasatskaya, Sofya A. Kasatskaya, Sofya A. Kasatskaya, Valeriia V. Kriukova, Valeriia V. Kriukova, Irina A. Shagina, Irina A. Shagina, Ekaterina M. Merzlyak, Ekaterina M. Merzlyak, Tatiana O. Nakonechnaya, Elena A. Latysheva, Irina A. Manto, Musa R. Khaitov, Sergey A. Lukyanov, Dmitriy M. Chudakov, Dmitriy M. Chudakov, Dmitriy M. Chudakov, Olga V. Britanova   +24 more
doaj   +1 more source