Results 11 to 20 of about 56,239 (298)
Molecular Therapy: Methods & Clinical Development, 2020 For resectable cancer patients, a method that could precisely predict the risk of postoperative recurrence would be crucial for guiding adjuvant treatment.
Zhengbo Song +10 more
doaj +3 more sources
Tracking TCRß sequence clonotype expansions during antiviral therapy using high-throughput sequencing of the hypervariable region [PDF]
, 2016 To maintain a persistent infection viruses such as hepatitis C virus (HCV) employ a range of mechanisms that subvert protective T cell responses. The suppression of antigen-specific T cell responses by HCV hinders efforts to profile T cell responses ...
Arvind H Patel +10 more
core +8 more sources
PLoS Pathogens, 2021 The CD4+ T cell response is critical to host protection against helminth infection. How this response varies across different hosts and tissues remains an important gap in our understanding. Using IL-4-reporter mice to identify responding CD4+ T cells to
Ivy K Brown +16 more
doaj +1 more source
The T‐cell receptor repertoire of regulatory T cells [PDF]
Immunology, 2008 SummaryThe CD4+ CD25+ regulatory population of T cells (Treg cells), which expresses the forkhead family transcription factor (Foxp3), is the key component of the peripheral tolerance mechanism that protects us from a variety of autoimmune diseases.
Rafal, Pacholczyk, Joanna, Kern
openaire +2 more sources
Overall avidity declines in TCR repertoires during latent CMV but not EBV infection
Frontiers in Immunology, 2023 IntroductionThe avidity of the T-cell receptor (TCR) for antigenic peptides presented by the MHC (pMHC) on cells is an essential parameter for efficient T cell-mediated immunity. Yet, whether the TCR-ligand avidity can drive the clonal evolution of virus
Barbara Couturaud +7 more
doaj +1 more source
Cell activation-based screening of natively paired human T cell receptor repertoires
Scientific Reports, 2023 Adoptive immune therapies based on the transfer of antigen-specific T cells have been used successfully to treat various cancers and viral infections, but improved techniques are needed to identify optimally protective human T cell receptors (TCRs). Here
Ahmed S. Fahad +16 more
doaj +1 more source
Destabilizing the autoinhibitory conformation of Zap70 induces up-regulation of inhibitory receptors and T cell unresponsiveness. [PDF]
, 2017 Zap70 plays a critical role in normal T cell development and T cell function. However, little is known about how perturbation of allosteric autoinhibitory mechanisms in Zap70 impacts T cell biology.
Chen, Yiling +4 more
core +2 more sources
Frontiers in Immunology, 2019 Recognition of cancer antigens drives the clonal expansion of cancer-reactive T cells, which is thought to contribute to restricted T-cell receptor (TCR) repertoires in tumor-infiltrating lymphocytes (TILs).
Akiko Arakawa +7 more
doaj +1 more source
Frontiers in Immunology, 2020 Severe COVID-19 is associated with profound lymphopenia and an elevated neutrophil to lymphocyte ratio. We applied a novel dimer avoidance multiplexed polymerase chain reaction next-generation sequencing assay to analyze T (TCR) and B cell receptor (BCR)
Xuefeng Niu +26 more
doaj +1 more source
Alterations of T cell receptor Vβ repertoire of CD8 T lymphocytes in immune tolerance induction in two hemophilia A patients with inhibitors [PDF]
Vojnosanitetski Pregled, 2011 Background/Aim. Hemophilia A patients with inhibitors are treated effectively with immune tolerance induction (ITI) therapy. Although anti-idiotypic antibodies may play a certain role in the underlying mechanism, the detailed mechanism by which ITI ...
Sakurai Yoshihiko +5 more
doaj +1 more source