Results 1 to 10 of about 56,120 (183)

Regulation of T cell repertoires by commensal microbiota [PDF]

Frontiers in Cellular and Infection Microbiology, 2022
The gut microbiota plays an important role in regulating the host immune systems. It is well established that various commensal microbial species can induce the differentiation of CD4+ T helper subsets such as Foxp3+ regulatory T (Treg) cells and Th17 ...
Kwang Soon Kim
doaj   +2 more sources

Landscape of T‐cell repertoires with public COVID‐19‐associated T‐cell receptors in pre‐pandemic risk cohorts [PDF]

Clinical & Translational Immunology, 2021
Objectives T cells have an essential role in the antiviral defence. Public T‐cell receptor (TCR) clonotypes are expanded in a substantial proportion of COVID‐19 patients.
Donjete Simnica, Christoph Schultheiß, Malte Mohme, Lisa Paschold, Edith Willscher, Antonia Fitzek, Klaus Püschel, Jakob Matschke, Sandra Ciesek, Daniel G Sedding, Yu Zhao, Nicola Gagliani, Yacine Maringer, Juliane S Walz, Janna Heide, Julian Schulze‐zur‐Wiesch, Mascha Binder   +16 more
doaj   +2 more sources

Analysis of T cell repertoires of CD45RO CD4 T cells in cohorts of patients with bullous pemphigoid: A pilot study [PDF]

Frontiers in Immunology, 2022
Autoimmune diseases develop over years - starting from a subclinical phenotype to clinically manifest autoimmune disease. The factors that drive this transition are ill-defined.
Markus Niebuhr, Farbod Bahreini, Anke Fähnrich, Christina Bomholt, Katja Bieber, Enno Schmidt, Enno Schmidt, Saleh Ibrahim, Christoph M. Hammers, Christoph M. Hammers, Kathrin Kalies   +10 more
doaj   +2 more sources

Human and Murine Clonal CD8+ T Cell Expansions Arise during Tuberculosis Because of TCR Selection. [PDF]

PLoS Pathogens, 2015
The immune system can recognize virtually any antigen, yet T cell responses against several pathogens, including Mycobacterium tuberculosis, are restricted to a limited number of immunodominant epitopes.
Cláudio Nunes-Alves, Matthew G Booty, Stephen M Carpenter, Alissa C Rothchild, Constance J Martin, Danielle Desjardins, Katherine Steblenko, Henrik N Kløverpris, Rajhmun Madansein, Duran Ramsuran, Alasdair Leslie, Margarida Correia-Neves, Samuel M Behar   +12 more
doaj   +9 more sources

Learning predictive signatures of HLA type from T-cell repertoires. [PDF]

PLoS Computational Biology
T cells recognize a wide range of pathogens using surface receptors that interact directly with peptides presented on major histocompatibility complexes (MHC) encoded by the HLA loci in humans. Understanding the association between T cell receptors (TCR)
María Ruiz Ortega, Mikhail V Pogorelyy, Anastasia A Minervina, Paul G Thomas, Thierry Mora, Aleksandra M Walczak   +5 more
doaj   +2 more sources

T-cell repertoires in refractory coeliac disease. [PDF]

Gut, 2018
Refractory coeliac disease (RCD) is a potentially hazardous complication of coeliac disease (CD). In contrast to RCD type I, RCD type II is a precursor entity of enteropathy-associated T-cell lymphoma (EATL), which is associated with clonally expanding T-cells that are also found in the sequentially developing EATL.
Ritter J, Zimmermann K, Jöhrens K, Mende S, Seegebarth A, Siegmund B, Hennig S, Todorova K, Rosenwald A, Daum S, Hummel M, Schumann M.   +11 more
europepmc   +6 more sources

Oligoclonal B cell expansion and passenger fusion genes predict response to Nivolumab in recurrent ovarian cancer: phase II Kyoto trial [PDF]

Cancer Immunology, Immunotherapy
Background We previously reported a phase II Kyoto trial for platinum-resistant ovarian cancer (n = 20) using nivolumab (anti-programmed cell death-1 [PD-1] antibody).
Ryusuke Murakami, Junzo Hamanishi, J. B. Brown, Yuko Hosoe, Takuma Kobayashi, Teppei Konishi, Taito Miyamoto, Rin Mizuno, Mana Taki, Koji Yamanoi, Ken Yamaguchi, Masaki Mandai   +11 more
doaj   +2 more sources

Comparing T cell receptor repertoires using optimal transport.

PLoS Computational Biology, 2022
The complexity of entire T cell receptor (TCR) repertoires makes their comparison a difficult but important task. Current methods of TCR repertoire comparison can incur a high loss of distributional information by considering overly simplistic sequence ...
Branden J Olson, Stefan A Schattgen, Paul G Thomas, Philip Bradley, Frederick A Matsen Iv   +4 more
doaj   +2 more sources

CD8+ T-Cell Repertoire in Human Leukocyte Antigen Class I-Mismatched Alloreactive Immune Response

Frontiers in Immunology, 2021
In transplantation, direct allorecognition is a complex interplay between T-cell receptors (TCR) and HLA molecules and their bound peptides expressed on antigen-presenting cells. In analogy to HLA mismatched hematopoietic stem cell transplantation (HSCT),
Florence Bettens, Zuleika Calderin Sollet, Stéphane Buhler, Jean Villard   +3 more
doaj   +1 more source

Exploration of shared features of B cell receptor and T cell receptor repertoires reveals distinct clonotype clusters

Frontiers in Immunology, 2022
Although B cells and T cells are integral players of the adaptive immune system and act in co-dependent ways to orchestrate immune responses, existing methods to study the immune repertoire have largely focused on separate analyses of B cell receptor ...
Sang Bin Hong, Yong-Won Shin, Ja Bin Hong, Sang Kun Lee, Buhm Han, Buhm Han, Buhm Han   +6 more
doaj   +1 more source