Results 21 to 30 of about 56,239 (298)
Estimating T-cell repertoire diversity: limitations of classical estimators and a new approach [PDF]
, 2015 A highly diverse T-cell receptor (TCR) repertoire is a fundamental property of an effective immune system, and is associated with efficient control of viral infections and other pathogens. However, direct measurement of total TCR diversity is impossible.
Asquith, RE, Bangham, C, Laydon, D
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Tracking the T cell repertoire [PDF]
Nature Reviews Immunology, 2015 Ron Germain describes two seminal papers by Marc Jenkins and colleagues that introduced new techniques for analysis of the T cell repertoire.
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Frontiers in Microbiology, 2022 Characterization of T cell receptor (TCR) repertoires is essential for understanding the mechanisms of Mycobacterium tuberculosis (Mtb) infection involving T cell adaptive immunity.
Ming-Ming Shao +6 more
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Specific T-cell Activation in an Unspecific T-cell Repertoire [PDF]
Science Progress, 2011 T-cells are a vital type of white blood cell that circulate around our bodies, scanning for cellular abnormalities and infections. They recognise disease-associated antigens via a surface receptor called the T-cell antigen receptor (TCR). If there were a specific TCR for every single antigen, no mammal could possibly contain all the T-cells it needs ...
Berg, Hugo van den +2 more
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Specificity, Privacy, and Degeneracy in the CD4 T Cell Receptor Repertoire Following Immunization. [PDF]
, 2017 T cells recognize antigen using a large and diverse set of antigen-specific receptors created by a complex process of imprecise somatic cell gene rearrangements.
Best, K +8 more
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Shaping the T cell repertoire. [PDF]
The Journal of Immunology, 2005 Today immunologists are well aware of positive and negative selection of developing T cells. This was very different almost three decades ago when MHC-restricted Ag recognition by T cells represented an enormous puzzle in the absence of data on the molecular nature of Ag recognition by T cells ...
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Cell Reports, 2017 Summary: A diverse T cell receptor (TCR) repertoire is essential for controlling viral infections. However, information about TCR repertoires to defined viral antigens is limited.
Guobing Chen +8 more
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Persistent T Cell Repertoire Perturbation and T Cell Activation in HIV After Long Term Treatment
Frontiers in Immunology, 2021 ObjectiveIn people living with HIV (PLHIV), we sought to test the hypothesis that long term anti-retroviral therapy restores the normal T cell repertoire, and investigate the functional relationship of residual repertoire abnormalities to persistent ...
Carolin T. Turner +13 more
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Tracking global changes induced in the CD4 T-cell receptor repertoire by immunization with a complex antigen using short stretches of CDR3 protein sequence. [PDF]
, 2014 The clonal theory of adaptive immunity proposes that immunological responses are encoded by increases in the frequency of lymphocytes carrying antigen-specific receptors. In this study, we measure the frequency of different T-cell receptors (TcR) in CD4 +
Best, K +9 more
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T Cell Repertoires and Competitive Exclusion
Journal of Theoretical Biology, 1994 Self-renewal is generally thought to play a major role in the maintenance of the T-cell repertoire. Here we develop a set of mathematical models for T-cell activation by peptides on antigen presenting cells (APCs). We show that competition between T cells is inherent to the processes involved in T cells binding APCs.
Boer, R.J. de, Perelson, A.S.
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