Results 1 to 10 of about 7,102,602 (187)

Lrig1-expression confers suppressive function to CD4+ cells and is essential for averting autoimmunity via the Smad2/3/Foxp3 axis

Nature Communications, 2023
Regulatory T cells (Treg) are CD4+ T cells with immune-suppressive function, which is defined by Foxp3 expression. However, the molecular determinants defining the suppressive population of T cells have yet to be discovered.
Jae-Seung Moon, Chun-Chang Ho, Jong-Hyun Park, Kyungsoo Park, Bo-Young Shin, Su-Hyeon Lee, Ines Sequeira, Chin Hee Mun, Jin-Su Shin, Jung-Ho Kim, Beom Seok Kim, Jin-Wook Noh, Eui-Seon Lee, Ji Young Son, Yuna Kim, Yeji lee, Hee Cho, SunHyeon So, Jiyoon Park, Eunsu Choi, Jong-Won Oh, Sang-Won Lee, Tomohiro Morio, Fiona M. Watt, Rho Hyun Seong, Sang-Kyou Lee   +25 more
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Age-Related Gene Alteration in Naïve and Memory T cells Using Precise Age-Tracking Model

Frontiers in Cell and Developmental Biology, 2021
In aged individuals, age-related changes in immune cells, especially T cell deficiency, are associated with an increased incidence of infection, tumor, and autoimmune disease, as well as an impaired response to vaccination.
Xiaofeng Yang, Xiaofeng Yang, Xiaofeng Yang, Xin Wang, Xin Wang, Xin Wang, Lei Lei, Lei Lei, Lei Lei, Lina Sun, Lina Sun, Anjun Jiao, Anjun Jiao, Anjun Jiao, Kun Zhu, Kun Zhu, Tao Xie, Tao Xie, Haiyan Liu, Haiyan Liu, Xingzhe Zhang, Xingzhe Zhang, Yanhong Su, Yanhong Su, Cangang Zhang, Cangang Zhang, Lin Shi, Lin Shi, Dan Zhang, Dan Zhang, Huiqiang Zheng, Huiqiang Zheng, Jiahui Zhang, Jiahui Zhang, Xiaobin Liu, Xiaobin Liu, Xin Wang, Xin Wang, Xiaobo Zhou, Xiaobo Zhou, Chenming Sun, Chenming Sun, Baojun Zhang, Baojun Zhang, Baojun Zhang   +44 more
doaj   +1 more source

TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection. [PDF]

, 2016
HIV infection induces phenotypic and functional changes to CD8+ T cells defined by the coordinated upregulation of a series of negative checkpoint receptors that eventually result in T cell exhaustion and failure to control viral replication.
Abdel-Mohsen, Mohamed, Burwitz, Benjamin J, Chew, Glen M, Clayton, Kiera L, Deeks, Steven G, Fujita, Tsuyoshi, Hammond, Katherine B, Hansen, Scott G, Hecht, Frederick M, Ishii, Naoto, Korman, Alan J, Liegler, Teri, Maurer, Mark, Mitchell, Brooks I, Ndhlovu, Lishomwa C, Ostrowski, Mario, Reed, Jason S, Sacha, Jonah B, Shikuma, Cecilia M, Webb, Gabriela M, Wu, Helen L   +20 more
core   +12 more sources

Interplay between SMAD2 and STAT5A is a critical determinant of IL-17A/IL-17F differential expression

Molecular Biomedicine, 2021
Interleukins (IL)-17A and F are critical cytokines in anti-microbial immunity but also contribute to auto-immune pathologies. Recent evidence suggests that they may be differentially produced by T-helper (Th) cells, but the underlying mechanisms remain ...
Karla Fabiola Corral-Jara, Camille Chauvin, Wassim Abou-Jaoudé, Maximilien Grandclaudon, Aurélien Naldi, Vassili Soumelis, Denis Thieffry   +6 more
doaj   +1 more source

Determination of the level of CD4CD69 T cells in hemodialysis patients

Journal of Medicine in Scientific Research, 2022
Introduction The CD4 helper T cell is responsible for humoral, cellular immunity, and inflammation. CD69 may be a sensitive marker indicating that the CD4 T cell is activated.
Azza A I. Elmenyawi, Ahmed A A. Megeed, Nehad R Ibrahim, Mohamed Salah   +3 more
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Nutrients Interaction with the Immune System [PDF]

Archives of Razi Institute, 2021
This study described the interactions of different nutritional components with the immune system. A detailed search was carried out on Google Scholar and PubMed databases to find out the relevant research studies using different keywords, such as ...
S Noor, S Piscopo, A Gasmi
doaj   +1 more source

Deciphering the combinatorial landscape of immunity

eLife, 2020
From cellular activation to drug combinations, immunological responses are shaped by the action of multiple stimuli. Synergistic and antagonistic interactions between stimuli play major roles in shaping immune processes.
Antonio Cappuccio, Shane T Jensen, Boris M Hartmann, Stuart C Sealfon, Vassili Soumelis, Elena Zaslavsky   +5 more
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Systemic Sclerosis and Atherosclerosis: Potential Cellular Biomarkers and Mechanisms

Frontiers in Bioscience-Scholar, 2023
Systemic sclerosis (SSc) is a rare systemic autoimmune disease of unknown etiology, which is characterized by endothelial dysfunction, pathologic vasculopathy, and increased tissue fibrosis. Traditionally, SSc has been regarded as a prototypical fibrotic
Elena V. Gerasimova, Rushana U. Shayakhmetova, Daria A. Gerasimova, Tatiana V. Popkova, Lidia P. Ananyeva   +4 more
doaj   +1 more source

Innate-like NKp30+CD8+ T cells armed with TCR/CAR target tumor heterogeneity

OncoImmunology, 2021
Intratumoral heterogeneity is frequently associated with tumor immune escape, with MHC-class I and antigen expression loss rendering tumor cells invisible to T cell killing, representing a major challenge for the design of successful adoptive transfer ...
Margareta P. Correia, Ana Stojanovic, Winfried S. Wels, Adelheid Cerwenka   +3 more
doaj   +1 more source

Designing structure and E. coli strain-producer bearing SARS-CoV-2 N, S, M, E protein-related sequence antigen

Инфекция и иммунитет, 2023
T-cell immune response is extremely important in protecting human body from diverse viral infections. It is known that it can ensure viral clearance and complete recovery in patients with humoral immunodeficiency.
Vladimir V. Kopat, Anastasia A. Riabchenkova, Evgenii L. Chirak, Elizaveta R. Chirak, Anna I. Saenko, Nikolai N. Kolmakov, Andrey S. Simbirtsev, Ilya V. Dukhovlinov, Areg A. Totolian   +8 more
doaj   +1 more source