Results 11 to 20 of about 7,102,622 (207)

Alteration in innate immune cues assessed by analyzing peripheral blood immune system in post-covid patients

Инфекция и иммунитет, 2023
The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has led to global morbidity and mortality. Some patients fully recover from COVID-19, whereas around 45% subjects suffer from various persistent symptoms (fatigue, cognitive impairment, impaired ...
Maria A. Dobrynina, Aleksandr V. Zurochka, Mariia V. Komelkova, Vladimir A. Zurochka, Evgeny A. Praskurnichiy, Liana V. Ryabova, Alexey P. Sarapultsev   +6 more
doaj   +1 more source

Role of Vav1, a hematopoietic signal transduction molecule, as an adaptor protein in health and disease

Exploration of Immunology, 2023
The growth and differentiation of normal cells are controlled by protein-tyrosine kinases, which serve as receptors for a wide variety of external signals.
Shulamit Katzav
doaj   +1 more source

Effect of protein complex Nogo66-FA on retinal microenvironment in rats with chronic intraocular hypertension

Di-san junyi daxue xuebao, 2021
Objective To investigate the effect of protein complex, Nogo66 and Freund's adjuvant (FA), on retinal microenvironment in rats with chronic ocular hypertension. Methods After the rat model of chronic high intraocular pressure was established on the right
CHENG Ming, HE Xiangge
doaj   +1 more source

Apoptotic epitope-specific CD8+ T cells and interferon signaling intersect in chronic hepatitis C virus infection [PDF]

, 2015
CD8(+) T cells specific to caspase-cleaved antigens derived from apoptotic T cells represent a principal player in chronic immune activation (CIA). Here, we found that both apoptotic epitope (AE)-specific and hepatitis C virus (HCV)-specific CD8(+) T ...
Accapezzato, Daniele, Barnaba, Vincenzo, Calvo, Ludovica, Cavallari, EUGENIO NELSON, Citro, Alessandra, Coccia, Eliana M, D'Ettorre, Gabriella, DE MARZIO, Paolo, DI FILIPPO, Simona, Grazi, Gian Luca, Labbadia, Giancarlo, Martini, Helene, Martire, Carmela, Piconese, Silvia, Rizzo, Fabiana, Sette, Alessandro, Severa, Martina, Sidney, John, Vullo, Vincenzo   +18 more
core   +1 more source

Deoxynivalenol Has the Capacity to Increase Transcription Factor Expression and Cytokine Production in Porcine T Cells

Frontiers in Immunology, 2020
Deoxynivalenol (DON) is a Fusarium mycotoxin that frequently contaminates the feed of farm animals. Pigs with their monogastric digestive system are in particular sensitive to DON-contaminated feed. At high concentrations, DON causes acute toxic effects,
Eleni Vatzia, Alix Pierron, Anna Maria Hoog, Armin Saalmüller, Elisabeth Mayer, Wilhelm Gerner   +5 more
doaj   +1 more source

Tolerance without clonal expansion: Self-antigen-expressing B cells program self-reactive T cells for future deletion [PDF]

, 2008
B cells have been shown in various animal models to induce immunological tolerance leading to reduced immune responses and protection from autoimmunity.
Anderton, Stephen M., Bettelli, Estelle, Buch, Thorsten, Frommer, Friederike, Heinen, Tobias J. A. J., Mueller, Werner, Roers, Axel, Waisman, Ari, Wunderlich, F. Thomas, Yogev, Nir   +9 more
core   +1 more source

Transcript-indexed ATAC-seq for precision immune profiling. [PDF]

, 2018
T cells create vast amounts of diversity in the genes that encode their T cell receptors (TCRs), which enables individual clones to recognize specific peptide-major histocompatibility complex (MHC) ligands. Here we combined sequencing of the TCR-encoding
Buenrostro, Jason D, Chang, Howard Y, Corces, M Ryan, Davis, Mark M, Gennert, David G, Granja, Jeffrey M, Greenleaf, William J, Khavari, Paul A, Khodadoust, Michael S, Kim, Youn H, Lareau, Caleb A, Li, Rui, Mumbach, Maxwell R, Parker, Kevin R, Qi, Yanyan, Rubin, Adam J, Saligrama, Naresha, Satpathy, Ansuman T, Schep, Alicia N, Serratelli, William S, Wei, Yuning, Wu, Beijing   +21 more
core   +1 more source

Persistent immune activation in CVID and the role of IVIg in its suppression

Frontiers in Immunology, 2014
Common variable immunodeficiency (CVID) is one of the most common and clinically important primary immune deficiencies. CVID patients have poor humoral immunity resulting in recurrent infections of the gastrointestinal and upper respiratory tracts, as ...
Dominic ePaquin-Proulx, Johan K. Sandberg   +1 more
doaj   +1 more source

Ability of γδ T cells to modulate the Foxp3 T cell response is dependent on adenosine. [PDF]

, 2018
Whether γδ T cells inhibit or enhance the Foxp3 T cell response depends upon their activation status. The critical enhancing effector in the supernatant is adenosine.
Born, Willi K, Kaplan, Henry J, Liang, Dongchun, O'Brien, Rebecca L, Shao, Hui, Sun, Deming, Woo, Jeong-Im   +6 more
core   +3 more sources

T cell aging: A review of the transcriptional changes determined from genome-wide analysis

Frontiers in Immunology, 2013
Age carries a detrimental impact on T cell function. In the past decade, analyses of the genome-scale transcriptional changes of T cells during aging have yielded a large amount of data and provided a global view of gene expression changes in T cells ...
Guobing eChen, Ana eLustig, Nan-ping eWeng   +2 more
doaj   +1 more source