Results 21 to 30 of about 27,710,413 (387)

Systemic Sclerosis and Atherosclerosis: Potential Cellular Biomarkers and Mechanisms

Frontiers in Bioscience-Scholar, 2023
Systemic sclerosis (SSc) is a rare systemic autoimmune disease of unknown etiology, which is characterized by endothelial dysfunction, pathologic vasculopathy, and increased tissue fibrosis. Traditionally, SSc has been regarded as a prototypical fibrotic
Elena V. Gerasimova, Rushana U. Shayakhmetova, Daria A. Gerasimova, Tatiana V. Popkova, Lidia P. Ananyeva   +4 more
doaj   +1 more source

T cells in health and disease

Signal Transduction and Targeted Therapy, 2023
T cells are crucial for immune functions to maintain health and prevent disease. T cell development occurs in a stepwise process in the thymus and mainly generates CD4+ and CD8+ T cell subsets.
Lina Sun, Yanhong Su, Anjun Jiao, Xin Wang, Baojun Zhang   +4 more
semanticscholar   +1 more source

Innate-like NKp30+CD8+ T cells armed with TCR/CAR target tumor heterogeneity

OncoImmunology, 2021
Intratumoral heterogeneity is frequently associated with tumor immune escape, with MHC-class I and antigen expression loss rendering tumor cells invisible to T cell killing, representing a major challenge for the design of successful adoptive transfer ...
Margareta P. Correia, Ana Stojanovic, Winfried S. Wels, Adelheid Cerwenka   +3 more
doaj   +1 more source

Designing structure and E. coli strain-producer bearing SARS-CoV-2 N, S, M, E protein-related sequence antigen

Инфекция и иммунитет, 2023
T-cell immune response is extremely important in protecting human body from diverse viral infections. It is known that it can ensure viral clearance and complete recovery in patients with humoral immunodeficiency.
Vladimir V. Kopat, Anastasia A. Riabchenkova, Evgenii L. Chirak, Elizaveta R. Chirak, Anna I. Saenko, Nikolai N. Kolmakov, Andrey S. Simbirtsev, Ilya V. Dukhovlinov, Areg A. Totolian   +8 more
doaj   +1 more source

Alteration in innate immune cues assessed by analyzing peripheral blood immune system in post-covid patients

Инфекция и иммунитет, 2023
The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has led to global morbidity and mortality. Some patients fully recover from COVID-19, whereas around 45% subjects suffer from various persistent symptoms (fatigue, cognitive impairment, impaired ...
Maria A. Dobrynina, Aleksandr V. Zurochka, Mariia V. Komelkova, Vladimir A. Zurochka, Evgeny A. Praskurnichiy, Liana V. Ryabova, Alexey P. Sarapultsev   +6 more
doaj   +1 more source

Role of Vav1, a hematopoietic signal transduction molecule, as an adaptor protein in health and disease

Exploration of Immunology, 2023
The growth and differentiation of normal cells are controlled by protein-tyrosine kinases, which serve as receptors for a wide variety of external signals.
Shulamit Katzav
doaj   +1 more source

Effect of protein complex Nogo66-FA on retinal microenvironment in rats with chronic intraocular hypertension

Di-san junyi daxue xuebao, 2021
Objective To investigate the effect of protein complex, Nogo66 and Freund's adjuvant (FA), on retinal microenvironment in rats with chronic ocular hypertension. Methods After the rat model of chronic high intraocular pressure was established on the right
CHENG Ming, HE Xiangge
doaj   +1 more source

Apoptotic epitope-specific CD8+ T cells and interferon signaling intersect in chronic hepatitis C virus infection [PDF]

, 2015
CD8(+) T cells specific to caspase-cleaved antigens derived from apoptotic T cells represent a principal player in chronic immune activation (CIA). Here, we found that both apoptotic epitope (AE)-specific and hepatitis C virus (HCV)-specific CD8(+) T ...
Accapezzato, Daniele, Barnaba, Vincenzo, Calvo, Ludovica, Cavallari, EUGENIO NELSON, Citro, Alessandra, Coccia, Eliana M, D'Ettorre, Gabriella, DE MARZIO, Paolo, DI FILIPPO, Simona, Grazi, Gian Luca, Labbadia, Giancarlo, Martini, Helene, Martire, Carmela, Piconese, Silvia, Rizzo, Fabiana, Sette, Alessandro, Severa, Martina, Sidney, John, Vullo, Vincenzo   +18 more
core   +1 more source

TGF-β attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

Nature, 2018
Therapeutic antibodies that block the programmed death-1 (PD-1)–programmed death-ligand 1 (PD-L1) pathway can induce robust and durable responses in patients with various cancers, including metastatic urothelial cancer.
S. Mariathasan, S. Turley, D. Nickles, A. Castiglioni, Kobe Yuen, Yulei N. Wang, E. Kadel, H. Koeppen, Jillian L Astarita, R. Cubas, S. Jhunjhunwala, R. Banchereau, Yagai Yang, Y. Guan, Cecile Chalouni, James Ziai, Y. Şenbabaoğlu, Stephen P. Santoro, D. Sheinson, Jeffrey Hung, J. Giltnane, A. Pierce, Kathryn Mesh, Steve Lianoglou, Johannes Riegler, R. Carano, P. Eriksson, M. Hoglund, Loan Somarriba, D. Halligan, M. S. van der Heijden, Y. Loriot, J. Rosenberg, L. Fong, I. Mellman, Daniel S. Chen, Marjorie C. Green, C. Derleth, G. Fine, P. Hegde, R. Bourgon, T. Powles   +41 more
semanticscholar   +1 more source

Deoxynivalenol Has the Capacity to Increase Transcription Factor Expression and Cytokine Production in Porcine T Cells

Frontiers in Immunology, 2020
Deoxynivalenol (DON) is a Fusarium mycotoxin that frequently contaminates the feed of farm animals. Pigs with their monogastric digestive system are in particular sensitive to DON-contaminated feed. At high concentrations, DON causes acute toxic effects,
Eleni Vatzia, Alix Pierron, Anna Maria Hoog, Armin Saalmüller, Elisabeth Mayer, Wilhelm Gerner   +5 more
doaj   +1 more source