Results 31 to 40 of about 7,211,460 (310)

Increased frequency of TIGIT+CD73-CD8+ T cells with a TOX+ TCF-1low profile in patients with newly diagnosed and relapsed AML

OncoImmunology, 2021
The inhibitory receptor TIGIT, as well as theectonucleotidases CD39 and CD73 constitute potential exhaustion markers for T cells. Detailed analysis of these markers can shed light into dysregulation of the T-cell response in acute myeloid leukemia (AML ...
F. Brauneck, F Haag, R. Woost, N. Wildner, E. Tolosa, A. Rissiek, G. Vohwinkel, J. Wellbrock, C. Bokemeyer, J. Schulze zur Wiesch, C. Ackermann, W. Fiedler   +11 more
doaj   +1 more source

Water extract of pilose antler can inhibit breast cancer progression of the mouse through modulating its immune system

Food and Agricultural Immunology, 2018
Pilose antler (PA) is used to treat many diseases, but its effect on breast cancer is still unclear. Here, we report the effects of PA on the growth of the mouse mammary tumour in vitro and in vivo, and its effects on immune system of the tumor-bearing ...
Kexin Zheng, Chenghao Fu, Chunying Jiang, Xiqing Yue, Shiliang Ma   +4 more
doaj   +1 more source

T cells drive negative feedback mechanisms in cancer associated fibroblasts, promoting expression of co-inhibitory ligands, CD73 and IL-27 in non-small cell lung cancer

OncoImmunology, 2021
The success of immune checkpoint therapy shows tumor-reactive T cells can eliminate cancer cells but are restrained by immunosuppression within the tumor micro-environment (TME).
Richard A O’Connor, Vishwani Chauhan, Layla Mathieson, Helen Titmarsh, Lilian Koppensteiner, Irene Young, Giulia Tagliavini, David A Dorward, Sandrine Prost, Kevin Dhaliwal, William A Wallace, Ahsan R Akram   +11 more
doaj   +1 more source

Role of Vav1, a hematopoietic signal transduction molecule, as an adaptor protein in health and disease

Exploration of Immunology, 2023
The growth and differentiation of normal cells are controlled by protein-tyrosine kinases, which serve as receptors for a wide variety of external signals.
Shulamit Katzav
doaj   +1 more source

Early growth response gene 2 (Egr-2) controls the self-tolerance of T cells and prevents the development of lupuslike autoimmune disease [PDF]

, 2008
© 2008 Zhu et al. This article is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).Maintaining tolerance of T cells to self-antigens
Kioussis, Dimitris, Li, Suling, Martin, Joanne E., Symonds, Alistair L.J., Wang, Ping, Wraith, David C., Zhu, Bo   +6 more
core   +3 more sources

Systemic Sclerosis and Atherosclerosis: Potential Cellular Biomarkers and Mechanisms

Frontiers in Bioscience-Scholar, 2023
Systemic sclerosis (SSc) is a rare systemic autoimmune disease of unknown etiology, which is characterized by endothelial dysfunction, pathologic vasculopathy, and increased tissue fibrosis. Traditionally, SSc has been regarded as a prototypical fibrotic
Elena V. Gerasimova, Rushana U. Shayakhmetova, Daria A. Gerasimova, Tatiana V. Popkova, Lidia P. Ananyeva   +4 more
doaj   +1 more source

Pre-emptive and therapeutic adoptive immunotherapy for nasopharyngeal carcinoma: Phenotype and effector function of T cells impact on clinical response

OncoImmunology, 2017
Adoptive T cell therapy has emerged as a powerful strategy to treat human cancers especially haematological malignancies. Extension of these therapies to solid cancers remains a significant challenge especially in the context of defining immunological ...
Corey Smith, Victor Lee, Andrea Schuessler, Leone Beagley, Sweera Rehan, Janice Tsang, Vivian Li, Randal Tiu, David Smith, Michelle A. Neller, Katherine K. Matthews, Emma Gostick, David A. Price, Jacqueline Burrows, Glen M. Boyle, Daniel Chua, Benedict Panizza, Sandro V. Porceddu, John Nicholls, Dora Kwong, Rajiv Khanna   +20 more
doaj   +1 more source

Designing structure and E. coli strain-producer bearing SARS-CoV-2 N, S, M, E protein-related sequence antigen

Инфекция и иммунитет, 2023
T-cell immune response is extremely important in protecting human body from diverse viral infections. It is known that it can ensure viral clearance and complete recovery in patients with humoral immunodeficiency.
Vladimir V. Kopat, Anastasia A. Riabchenkova, Evgenii L. Chirak, Elizaveta R. Chirak, Anna I. Saenko, Nikolai N. Kolmakov, Andrey S. Simbirtsev, Ilya V. Dukhovlinov, Areg A. Totolian   +8 more
doaj   +1 more source

Metabolic reprogramming of human CD8+ memory T cells through loss of SIRT1. [PDF]

, 2017
The expansion of CD8+CD28- T cells, a population of terminally differentiated memory T cells, is one of the most consistent immunological changes in humans during aging.
Fei, Mingjian, Gordon, David E, Hull, Philip A, Jeng, Mark Y, Johnson, Jeffrey, Kasler, Herb, Krogan, Nevan, Kwon, Hye-Sook, Ng, Che-Ping, Ott, Melanie, Tsou, Chia-Lin, Verdin, Eric   +11 more
core   +1 more source

MAIT cells come to the rescue in cancer immunotherapy? [PDF]

, 2020
Recent progress in immunobiology has led to the observation that, among cells classically categorized as the typical representatives of the adaptive immune system, i.e., T cells, some possess the phenotype of innate cells.
Elewaut, Dirk, Venken, Koen, Łukasik, Zuzanna   +2 more
core   +2 more sources