Results 41 to 50 of about 27,710,413 (387)

Cytotoxic CD8+ T cells in cancer and cancer immunotherapy

British Journal of Cancer, 2020
The functions of, and interactions between, the innate and adaptive immune systems are vital for anticancer immunity. Cytotoxic T cells expressing cell-surface CD8 are the most powerful effectors in the anticancer immune response and form the backbone of
H. Raskov, A. Orhan, J. Christensen, I. Gögenur   +3 more
semanticscholar   +1 more source

The potential role of T-cells and their interaction with antigen-presenting cells in mediating immunosuppression following trauma-hemorrhage [PDF]

, 2009
Objective: Trauma-hemorrhage results in depressed immune responses of antigen-presenting cells (APCs) and T-cells. Recent studies suggest a key role of depressed T-cell derived interferon (IFN)-g in this complex immune cell interaction.
Abraham E., Angele MK, Angele MK, Christian P. Schneider, Christian R. Walz, Christiane J. Bruns, de Saint-Vis B., Ertel W., Eugen Faist, Florian Loehe, Irshad H. Chaudry, Landy M., Markus Albertsmeier, Martin K. Angele, Ransom J., Siegfried Zedler   +15 more
core   +1 more source

Protocol for engineering binding domains to recognize ligand-bound receptors by using yeast surface display

STAR Protocols
Summary: Yeast surface display is a versatile protein engineering technology, enabling precise control of the applied selection pressure. We present a yeast-surface-display-based protocol for the enrichment of binders specifically recognizing ligand ...
Markus Dobersberger, Delia Sumesgutner, Charlotte U. Zajc, Michael W. Traxlmayr   +3 more
doaj   +1 more source

Cofilin Activation in Peripheral CD4 T Cells of HIV-1 Infected Patients: A Pilot Study [PDF]

, 2008
Cofilin is an actin-depolymerizing factor that regulates actin dynamics critical for T cell migration and T cell activation. In unstimulated resting CD4 T cells, cofilin exists largely as a phosphorylated inactive form.
Barrett, Tracey, Liu, Juan, Schlauch, Karen, Wang, Weifeng, Wheeler, David, Wu, Yuntao, Yoder, Alyson, Yu, Dongyang   +7 more
core   +3 more sources

T Cell Hybrids with T Cell Functions

, 1979
Different T cell functions, e.g. help, suppression and cytotoxicity are associated with different T cell subsets, bearing distinctive differentiation markers. Thus effector T cells mediating help are Ly 1+2−3− and may bear Ia determinants, those mediating suppression are Ly 1−2+3+, IJ+, and cytotoxic cells are Ly 1−2+3+ and do not bear Ia determinants (
Simpson, E, Kontiainen, S, Herzenberg, L, Bohrer, E, Torano, A, Vogt, P, Beverley, P, Fitzpatrick, W, Feldmann, M   +8 more
openaire   +3 more sources

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

Journal of Immunology, 1995
Approximately 10% of peripheral CD4+ cells and less than 1% of CD8+ cells in normal unimmunized adult mice express the IL-2 receptor alpha-chain (CD25) molecules.
S. Sakaguchi, N. Sakaguchi, M. Asano, M. Itoh, M. Toda   +4 more
semanticscholar   +1 more source

Antitumor efficacy of a neoantigen cancer vaccine delivered by electroporation is influenced by microbiota composition

OncoImmunology, 2021
Cancer is a heterogeneous disease and its treatment remains unsatisfactory with inconstant therapeutic responses. This variability could be related, at least in part, to different and highly personalized gut microbiota compositions.
Lucia Lione, Erika Salvatori, Adriana Petrazzuolo, Alice Massacci, Roberta Maggio, Antonella Conforti, Mirco Compagnone, Luigi Aurisicchio, Gennaro Ciliberto, Fabio Palombo   +9 more
doaj   +1 more source

DR-bearing T lymphocytes in thoracic duct lymph [PDF]

, 1981
T cells having DR antigens were shown to be present in high numbers in the thoracic duct lymph of patients undergoing long-term drainage. As drainage progresses the proportion of T DR cells in the lymph increases to levels as high as 70% at 6 weeks ...
Abo, Albrechtson, Billing, Boyle, Colombani, Evans, Foon, Franksson, Fu, Greaves, H. Takahashi, J.C. Cicciarelli, Johnson, Kaplan, Machleder, Matell, Medawar, P.I. Terasaki, R. Billing, Starzl, Starzl, Suciu-Foca, T. Starzl, T. Yamaguchi, Terasaki, Y. Iwaki   +25 more
core   +1 more source

A Quality Improvement Initiative to Standardize Pneumocystis jirovecii Pneumonia Prophylaxis in Pediatric Patients With Solid Tumors

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric patients with extracranial solid tumors (ST) receiving chemotherapy are at an increased risk for Pneumocystis jirovecii pneumonia (PJP). However, evidence guiding prophylaxis practices in this population is limited. A PJP‐related fatality at our institution highlighted inconsistent prescribing approaches and concerns about
Kriti Kumar, Denise M. Connolly, Ellen Kellington, Elyse Zelunka, Karla Kerrigan, Furqan Shaikh, Paul C. Nathan, Meredith S. Irwin, Sarah Cohen‐Gogo   +8 more
wiley   +1 more source

Avidity of influenza-specific memory CD8+ T-cell populations decays over time compromising antiviral immunity [PDF]

, 2012
Decline of cell-mediated immunity is often attributed to decaying T-cell numbers and their distribution in peripheral organs. This study examined the hypothesis that qualitative as well as quantitative changes contribute to the declining efficacy of CD8+
Alexander-Miller, Almeida, Appay, Berger, Betts, Bosselut, Cerundolo, Gallimore, Gorman, Hansen, Hollander, Homann, Jelley-Gibbs, Jenkins, Jones, Jones, Judge, Karrer, Kattan, Kedzierska, Kim, Kohlmeier, Lefranc, Liang, Moffat, Neveu, Norbury, Powell, Price, Quigley, Rangel-Moreno, Richards, Roberts, Schluns, Tan, Tough, Trautmann, Valkenburg, Valkenburg, Woodland, Wooldridge, Zammit   +41 more
core   +1 more source