Results 71 to 80 of about 7,211,460 (310)

Anti-tumor immunity influences cancer cell reliance upon ATG7

OncoImmunology, 2020
Macroautophagy (autophagy) is an essential cellular catabolic process required for survival under conditions of starvation. The role of autophagy in cancer is complex, context-dependent and at times contradictory, as it has been shown to inhibit, promote
Michael D. Arensman, Xiaoran S. Yang, Wenyan Zhong, Stephanie Bisulco, Erik Upeslacis, Edward C. Rosfjord, Shibing Deng, Robert T. Abraham, Christina H. Eng   +8 more
doaj   +1 more source

Limiting energy dissipation induces glassy kinetics in single cell high precision responses [PDF]

, 2015
Single cells often generate precise responses by involving dissipative out-of-thermodynamic equilibrium processes in signaling networks. The available free energy to fuel these processes could become limited depending on the metabolic state of an individual cell.
arxiv   +1 more source

A new homeostatic model of the T cell system [PDF]

Journal of Biological Systems, 19, 299-317, 2011, 2010
Our main tenet argues that the primary role of positive thymic selection and the resulting T cell population is the maintenance of a homeostatic equilibrium with self MHC-self peptide complexes. The homeostatic T cell repertoire can recognize infections non-specifically and this is an indirect (negative) recognition: the whole homeostatic T cell ...
arxiv   +1 more source

Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells

FEBS Letters, EarlyView.
Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga, Kazuki Harada, Takuya Yamauchi, Tetsuya Kitaguchi, Masami Yokota Hirai, Mitsuharu Matsumoto, Takashi Tsuboi   +6 more
wiley   +1 more source

Distinct profiles of osteoclast and dendritic cell-mediated expansion and functional activation of NK and T cells

Cancer Immunology, Immunotherapy
Osteoclasts (OCs) and dendritic cells (DCs) induce expansion and functional activation of NK and T cells. When comparing OCs with DC-induced activation in NK cells, OCs induced significantly higher cell expansion and functional activation of NK cells as ...
Kawaljit Kaur, Anahid Jewett
doaj   +1 more source

Formation and phenotypic characterization of CD49a, CD49b and CD103 expressing CD8 T cell populations in human metastatic melanoma

OncoImmunology, 2018
Integrins α1β1 (CD49a), α2β1 (CD49b) and αEβ7 (CD103) mediate retention of lymphocytes in peripheral tissues, and their expression is upregulated on tumor infiltrating lymphocytes (TIL) compared to circulating lymphocytes.
Marit M. Melssen, Walter Olson, Nolan A. Wages, Brian J. Capaldo, Ileana S. Mauldin, Adela Mahmutovic, Ciara Hutchison, Cornelis J.M. Melief, Timothy N. Bullock, Victor H. Engelhard, Craig L. Slingluff   +10 more
doaj   +1 more source

Modern T cell technologies for immunotherapy of solid tumors

Медицинская иммунология, 2023
According to the common concept of immune editing, the interaction of malignant tumor cells and immune system is a complex multifactorial process, which may result in both antitumor effector activity and development of suppressor mechanisms that promote ...
M. S. Kuznetsova, Hiroshi Shiku, A. V. Karaulov, S. V. Sennikov   +3 more
doaj   +1 more source

T cell equation as a conceptual model of T cell responses for maximizing the efficacy of cancer immunotherapy [PDF]

SOJ Immunol 5(1):1-5, 2017, 2015
Following antigen stimulation, the net outcomes of a T cell response are shaped by integrated signals from both positive co-stimulatory and negative regulatory molecules. Recently, the blockade of negative regulatory molecules (i.e. immune checkpoint signals) demonstrates therapeutic effects in treatment of human cancer, but only in a fraction of ...
arxiv   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Attempt to assess direct interactions between tumor burden, myeloid-derived suppressor cells and PD-1- and TIM-3-expressing T cells in multiple myeloma patients

Медицинская иммунология, 2023
The avoidance of immune surveillance by malignant plasma cells (PCs) in multiple myeloma (MM) is mediated by different mechanisms, among which an induction of T cell exhaustion and expansion of myeloid-derived suppressor cells (MDSCs) appear to play ...
E. V. Batorov, T. A. Aristova, N. V. Pronkina, V. V. Denisova, S. A. Sizikova, G. Yu. Ushakova   +5 more
doaj   +1 more source