Results 71 to 80 of about 1,131,184 (349)

Description of the immune microenvironment of chondrosarcoma and contribution to progression

OncoImmunology, 2017
Chondrosarcoma (CHS) is a rare bone malignancy characterized by its resistance to conventional systemic and radiation therapies. Whether immunotherapy targeting immune checkpoints may be active in these tumors remains unknown.
François A. Simard, Iseulys Richert, Alexandra Vandermoeten, Anne-Valérie Decouvelaere, Jean-Philippe Michot, Christophe Caux, Jean-Yves Blay, Aurélie Dutour   +7 more
doaj   +1 more source

Target cell-dependent T cell-mediated lysis of vaccinia virus-infected cells [PDF]

, 1975
Vaccinia virus specific cytotoxicity against infected target cells was observed in vitro. Spleen lymphocytes from normal and immunized mice of the inbred strains C3H and DBA/2 were incubated with vaccinia virus-infected and non-infected 51Cr-labeled ...
Alkan, Boyum, Brunner, Calder, Cohen, Epstein, Evans, Fulginiti, Gardner, Gardner, Glasgow, Good, Hecht, Janossy, Julius, Koszinowski, Labowskie, Lohmann-Mathes, Lundstedt, Marker, McFarland, Oldstone, Perlmann, Perlmann, Profitt, Schirrmacher, Shearer, Shortman, Speel, Steele, Ueda, Ueda, Von Pirquet, Wagner, Wagner, Zinkernagel, Zinkernagel   +36 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Bioinformatics designing of an mRNA vaccine for Mokola virus (MOKV) using immunoinformatics as a secure strategy for successful vaccine development

BMC Immunology
The Mokola Virus belongs to the family Rhabdoviridae and is genotype 3 of the Lyssavirus genera. A small number of cases of animal and human encephalomyelitis, mainly scattered over sub-Saharan Africa, have been linked to the Mokola Virus (MOKV ...
Elijah Kolawole Oladipo, James Akinwumi Ogunniran, Oluwaseyi Samuel Akinpelu, Tosin Omoboyede Omole, Stephen Feranmi Adeyemo, Boluwatife Ayobami Irewolede, Bamidele Abiodun Iwalokun, Olumide Faith Ajani, Helen Onyeaka   +8 more
doaj   +1 more source

altered expression of cD300a inhibitory receptor on cD4+ T cells From human immunodeficiency Virus-1-infected Patients: association With Disease Progression Markers. [PDF]

, 2018
The ability of the CD300a inhibitory receptor to modulate immune cell functions and its involvement in the pathogenesis of many diseases has aroused a great interest in this molecule.
Genebat González, Miguel, Leal Noval, Manuel, Ruiz-Mateos Carmona, Ezequiel, Tarancon Diez, Laura   +3 more
core   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Generating CAR T cells from tumor-infiltrating lymphocytes

Therapeutic Advances in Vaccines and Immunotherapy, 2021
Background: Tumor-infiltrating lymphocytes (TILs) and chimeric antigen receptor (CAR) T-cell therapies have demonstrated promising, though limited, efficacy against melanoma.
Jane K. Mills, Melissa A. Henderson, Lauren Giuffrida, Pasquale Petrone, Jennifer A. Westwood, Phillip K. Darcy, Paul J. Neeson, Michael H. Kershaw, David E. Gyorki   +8 more
doaj   +1 more source

Antigen-specific electrophoretic cell separation for immunological investigations [PDF]

, 1989
Preincubation of human blood lymphocytes with cell surface antigen specific antibodies under non-capping conditions reduces the electrophoretic mobility of the corresponding lymphocyte subpopulation.
Hannig, K., Hansen, Ernil, Wustrow, T. P.   +2 more
core   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source