Results 71 to 80 of about 12,046,757 (352)

Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes

Journal of Experimental Medicine, 1996
A human receptor that is selective for the CXC chemokines IP10 and Mig was cloned and characterized. The receptor cDNA has an open reading frame of 1104-bp encoding a protein of 368 amino acids with a molecular mass of 40,659 dalton.
M. Loetscher, Basil Gerber, P. Loetscher, Simon A. Jones, L. Piali, Ian Clark-Lewisfl, M. Baggiolini, B. Moser   +7 more
semanticscholar   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Interrelation of tumor infiltrating lymphocyte subpopulations with clinical and pathomorphological features of a breast cancer

Опухоли женской репродуктивной системы, 2016
Levels of intratumoral lymphocytes have direct interrelations with clinical, morphological and biological characteristics of tumor. Rates of CD4+lymphocytes rise in a process of increase of tumor size.
O. A. Beznos, D. A. Burov, V. Yu. Sel’chuk, I. K. Vorotnikov, V. V. Timoshenko, T. A. Grigor’eva, Ya. V. Vishnevskaya, N. N. Tupitsyn   +7 more
doaj   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

T cell subsets' distribution in elite karate athletes as a response to physical effort [PDF]

Journal of Medical Biochemistry, 2019
Background: During karate fight muscles work at a very high intensity, and their contractions are extremely strong. The movement pattern contains a great number of feints, dodges, frequent changes in movements' tempo and direction, hits and kicks, all of
Kostrzewa-Nowak Dorota, Rafał Buryta, Nowak Robert   +2 more
doaj  

FUNCTIONAL AORTIC STIFFNESS:ROLE OF CD4+ T LYMPHOCYTES

Frontiers in Physiology, 2015
The immune system is suggested to be essential in vascular remodeling and stiffening. To study the dependence upon lymphocytes in vascular stiffening, we compared an angiotensin II-model of vascular stiffening in normal C57BL/6J mice with lymphocyte ...
Beenish A. Majeed, Lance S. Eberson, Supannikar eTawinwung, Nicolas eLarmonier, Timothy W. Secomb, Douglas F Larson   +5 more
doaj   +1 more source

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

Influence of the biophosphomag preparation and biologically active substances from milk thistle seeds (Silybum marianum) on the metabolism of lymphocytes and their functional features

Біологічні студії
Background. The OVA and patented OVA+ preparations (produced by NULES of Ukraine) were obtained according to O. V. Arnauta et al. (2021) by extracting biologically active compounds from the seeds of milk thistle (Silybum marianum) using corn oil.
Petro Fedyshyn, Olga Pavliuk, Ivan Stupak, Taisa Dovbynchuk, Yulia Pysmenna, Volodymyr Liashenko, Natalia Senchylo, Serhii Holopura, Liliia Kalachniuk, Liudmyla Garmanchuk   +9 more
doaj   +1 more source

Allorecognition by T lymphocytes and allograft rejection

Frontiers in Immunology, 2016
Recognition of donor antigens by recipient T cells in secondary lymphoid organs initiates the adaptive inflammatory immune response leading to the rejection of allogeneic transplants.
Gilles Benichou, Jose Marino, Joshua Paster   +2 more
doaj   +1 more source

Primary HIV-1 Infection Is Associated with Preferential Depletion of CD4+ T Lymphocytes from Effector Sites in the Gastrointestinal Tract

Journal of Experimental Medicine, 2004
Given its population of CCR5-expressing, immunologically activated CD4+ T cells, the gastrointestinal (GI) mucosa is uniquely susceptible to human immunodeficiency virus (HIV)-1 infection.
S. Mehandru, M. Poles, K. Tenner‐Racz, A. Horowitz, A. Hurley, Christine M. Hogan, D. Boden, P. Rácz, M. Markowitz   +8 more
semanticscholar   +1 more source