A self-degradable hydrogel sensor for a nerve agent tabun surrogate through a self-propagating cascade [PDF]
Cell Reports Physical Science, 2021 Summary: Nerve agents that irreversibly deactivate the enzyme acetylcholinesterase are extremely toxic weapons of mass destruction. Thus, developing methods to detect these lethal agents is important.
Doo-Hee Lee +5 more
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Qualitative Analysis of Novel Flavonoid Adducts from Nerve Agent Tabun-Exposed Arabidopsis thaliana (L.) Based on Quadrupole–Time of Flight Mass Spectrometry [PDF]
Molecules, 2023 Flavonoids are a kind of secondary metabolite which widely exist in plants. They contain a lot of active hydroxyls, which can react with toxic chemicals to produce potential exposure biomarkers.
Zhongfang Xing +8 more
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A Comparison of the Neuroprotective and Reactivating Efficacy of a Novel Bispyridinium Oxime K870 with Commonly Used Pralidoxime and the Oxime HI-6 in Tabun-Poisoned Rat [PDF]
Acta Medica, 2021 Aim: The comparison of neuroprotective and central reactivating effects of the oxime K870 in combination with atropine with the efficacy of standard antidotal treatment in tabun-poisoned rats.
Jiří Kassa +5 more
doaj +3 more sources
Ethnomathematics on Dayak Tabun Traditional Tools for School Mathematics Learning
International Journal of Trends in Mathematics Education Research, 2019 The purpose of this study was to describe ethnomathematics on Dayak Tabun traditional tools in school mathematics learning. This study uses a qualitative approach, with descriptive research methods.
Hartono Hartono, Marhadi Saputro
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Anticholinergic Drugs – Functional Antidotes for the Treatment of Tabun Intoxication [PDF]
Acta Medica, 2004 Summary: 1. To study the influence of antidotes on tabun-induced neurotoxicity, the rats were injected intramuscularly with organophosphate tabun (LD50).
Gabriela Krejčová, Jiří Kassa
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The Influence of the Time of Antidotal Treatment Administration on Its Effectiveness Against Tabun-Induced Poisoning in Mice [PDF]
Acta Medica, 2004 Summary: 1. The influence of the time of administration of antidotal treatment consisting of anticholinergic drug (atropine) and oxime (pralidoxime, obidoxime, HI-6 or trimedoxime) on its effectiveness to eliminate tabun-induced lethal effects was ...
Jiří Kassa
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Influence of Experimental End Point on the Therapeutic Efficacy of Essential and Additional Antidotes in Organophosphorus Nerve Agent-Intoxicated Mice [PDF]
Toxics, 2022 The therapeutic efficacy of treatments for acute intoxication with highly toxic organophosphorus compounds, called nerve agents, usually involves determination of LD50 values 24 h after nerve agent challenge without and with a single administration of ...
Jiri Kassa +4 more
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Energetics of Ortho-7 (oxime drug) translocation through the active-site gorge of tabun conjugated acetylcholinesterase. [PDF]
PLoS ONE, 2012 Oxime drugs translocate through the 20 Å active-site gorge of acetylcholinesterase in order to liberate the enzyme from organophosphorus compounds' (such as tabun) conjugation.
Vivek Sinha +2 more
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In silico studies in probing the role of kinetic and structural effects of different drugs for the reactivation of tabun-inhibited AChE. [PDF]
PLoS ONE, 2013 We have examined the reactivation mechanism of the tabun-conjugated AChE with various drugs using density functional theory (DFT) and post-Hartree-Fock methods. The electronic environments and structural features of neutral oximes (deazapralidoxime and 3-
Rabindranath Lo +4 more
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Counteracting poisoning with chemical warfare nerve agents [PDF]
Arhiv za Higijenu Rada i Toksikologiju, 2020 Phosphylation of the pivotal enzyme acetylcholinesterase (AChE) by nerve agents (NAs) leads to irreversible inhibition of the enzyme and accumulation of neurotransmitter acetylcholine, which induces cholinergic crisis, that is, overstimulation of ...
Hrvat Nikolina Maček, Kovarik Zrinka
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