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Delayed neuropathy by the organophosphorus nerve agents soman and tabun
Archives of Toxicology, 1984The organophosphorus nerve agents soman and tabun were tested in the hen at doses 120-150 times higher than their acute LD50, as it was assumed that these doses would produce delayed neuropathy. The animals were protected against the acute lethal effect of these agents by pretreatment with atropine, physostigmine, diazepam, and the oxime HI-6 or ...
J L, Willems +2 more
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Oxime K203: a drug candidate for the treatment of tabun intoxication
Archives of Toxicology, 2018For over 60 years, researchers across the world have sought to deal with poisoning by nerve agents, the most toxic and lethal chemical weapons. To date, there is no efficient causal antidote with sufficient effect. Every trialed compound fails to fulfil one or more criteria (e.g. reactivation potency, broad reactivation profile).
Lukas Gorecki +7 more
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Diisopropylphosphorofluoridate and Tabun: Enzymatic Hydrolysis and Nerve Function
Science, 1971Squid nerve contains an enzyme that hydrolyzes the nerve gas Tabun at about one-tenth the rate it hydrolyzes diisopropylphosphorofluoridate (DFP), and at about one-third to one-fourth the rate it hydrolyzes Sarin and Soman. Tabun is a more potent inhibitor of acetylcholinesterase than is DFP, is both lipid- and water-soluble, and penetrates readily ...
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Tabun scavengers based on hydroxamic acid containing cyclodextrins
Chemical Communications, 2013Arrangement of several hydroxamic acid-derived substituents along the cavity of a cyclodextrin ring leads to compounds that detoxify tabun in TRIS-HCl buffer at physiological pH and 37.0 °C with half-times as low as 3 min.
Florian, Brandhuber +7 more
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Role of Carboxylesterase in Soman, Sarin and Tabun Poisoning in Rats
Pharmacology & Toxicology, 1989Abstract:TOCP (triorthocresyl phosphate) inhibits carboxylesterase (CarbE) activity in rat plasma and liver and significantly increases soman, sarin and tabun toxicity. Application of these agents after TOCP caused strong additional inhibition of CarbE and cholinesterases (ChE) in rat red blood cells, plasma, liver, brain, diaphragm and intercostal ...
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