Results 91 to 100 of about 4,888 (209)

Effects of TAK-480, a Novel Tachykinin NK2–Receptor Antagonist, on Visceral Hypersensitivity in Rabbits and Ricinoleic Acid–Induced Defecation in Guinea Pigs

Journal of Pharmacological Sciences, 2012
TAK-480, 4-(difluoromethoxy)-N-((1R,2S)-2-(((3aR,4R,9bR)-4-(methoxymethyl)-2, 3,3a,4,5,9b-hexahydro-1H-pyrrolo[3,2-c]quinolin-1-yl)carbonyl)cyclohexyl)benzamide, is a novel tachykinin NK2–receptor antagonist.
Takahiro Tanaka, Akiko Tanaka, Akihiro Nakamura, Kozo Matsushita, Akio Imanishi, Shiho Matsumoto-Okano, Nobuhiro Inatomi, Kasei Miura, Masao Toyoda, Gaku Mizojiri, Yasuhiro Tsukimi   +10 more
doaj   +1 more source

Mapping of brain sites sensitive to the antidipsogenic effect of tachykinins.

, 1988
The present study investigated the sensitivity of 12 forebrain and midbrain structures to the antidipsogenic effect of eledoisin, physalaemin and substance P on angiotensin-induced drinking.
PERFUMI, Marina Cecilia, de Caro G, MASSI, Maurizio, Venturi F.   +3 more
core   +1 more source

A Chitosan—Based Liposome Formulation Enhances the In Vitro Wound Healing Efficacy of Substance P Neuropeptide

Pharmaceutics, 2017
Currently, there is considerable interest in developing innovative biodegradable nanoformulations for controlled administration of therapeutic proteins and peptides.
Tamara Mengoni, Manuela Adrian, Susana Pereira, Beatriz Santos-Carballal, Mathias Kaiser, Francisco M. Goycoolea   +5 more
doaj   +1 more source

Tachykinins mediate vagal inhibition of gastrin secretion in pigs

, 1996
Electrical vagal stimulation activates both stimulatory and inhibitory nerve fibers regulating gastrin release in the porcine antrum. The aim of this study was to examine the role of tachykinins in the inhibitory vagal control of gastrin release in the ...
Rasmussen, T N, Schmidt, P, Poulsen, Steen Seier, Holst, J J, Hilsted, L   +4 more
core  

Tachykinins (Substance P, Neurokinin A, Neuropeptide K, and Neurokinin B) in the Cerebral Circulation: Vasomotor Responses in vitro and in situ

, 1991
The vasomotor responses of tachykinins have been studied in the cerebral vasculature of human, pig, cat, and guinea pig. Substance P (SP), neurokinin A (NKA), neurokinin B (NKB), and neuropeptide K (NPK) induced concentration-dependent relaxations of ...
I. Jansen, C. Alafaci, J. McCulloch, L. Edvinsson, R. Uddman, ALAFACI, Concetta, MCCULLOCH J, JANSEN I, EDVINSSON L., UDDMAN R   +9 more
core   +1 more source

Protochordata tachykinin [PDF]

Journal of Biological Chemistry, 2016
Honoo Satake, Michio Ogasawara, Tsuyoshi Kawada, Katsuyoshi Masuda, Masato Aoyama, Hiroyuki Minakata, Takuto Chiba, Hitoe Metoki, Yutaka Satou, Nori Satoh   +9 more
openaire   +2 more sources

Discovery of defense- and neuropeptides in social ants by genome-mining.

PLoS ONE, 2012
Natural peptides of great number and diversity occur in all organisms, but analyzing their peptidome is often difficult. With natural product drug discovery in mind, we devised a genome-mining approach to identify defense- and neuropeptides in the ...
Christian W Gruber, Markus Muttenthaler
doaj   +1 more source

Tachykinins: local gastric effects and brain stem responses

, 1987
The gastric motor or mechanical effects of a group of peptides, the tachykinins, were evaluated in anesthetized cats to determine the relationship between local motor events and brain stem neurons that regulate gastric activity.
G. D. Stevenson, W. D. Barber, T. F. Burks   +2 more
core   +1 more source

Migration and proliferation of guinea pig and human airway epithelial cells in response to tachykinins

, 1995
Restoration of the epithelial lining of a damaged airway is a necessary component of airway repair. Tachykinins, including substance P (SP) and neurokinin A (NKA), are localized to sensory nerves within the airway mucosa.
S. R. White, H. Magnussen, J. S. Kim, J. M. Green, K. F. Rabe   +4 more
core   +1 more source

Peripheral tachykinins and the NK1 receptor regulate platelet function

, 2007
Tachykinins are a family of neuropeptides characterised by the conserved C-terminal motif FXGLM-NH2, where X represents a hydrophobic amino acid. Substance P (SP) a member of the tachykinin family has recently been shown to stimulate platelet aggregation
Jones, Sarah
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