Results 71 to 80 of about 4,888 (209)
British Journal of Pharmacology, Volume 183, Issue 16, Page 4512-4531, August 2026.The G protein–coupled receptor (GPCR) superfamily consists of the most common targets of approved drugs. Targeting GPCRs offers appealing avenues for therapeutic development. Antibodies and their fragments, such as single‐domain antibodies (VHHs or nanobodies), have emerged as useful alternatives to small molecule pharmacophores as building blocks in ...
Shivani Sachdev, Ross W. Cheloha
wiley +1 more source
Acta Dermato-Venereologica, 2017 Atopic dermatitis (AD) is a chronic, itchy, inflammatory skin disorder that may worsen due to stress and anxiety. Tachykinins have been suggested to be involved in the inflammation in AD, as well as pruritus.
Louise Lönndahl +8 more
doaj +1 more source
Beyond Histamine: Mast Cell‐Neuron Communication in Chronic Pruritic and Pain Disorders
Experimental Dermatology, Volume 35, Issue 8, August 2026.ABSTRACT Chronic pruritic and cutaneous pain disorders are increasingly recognized as neuroimmune conditions driven by dynamic interactions between immune and sensory systems. While histamine has historically dominated models of mast cell‐mediated itch, accumulating evidence indicates that non‐histaminergic pathways are central to chronic disease.
Tomer Kagan, Gil Yosipovitch
wiley +1 more source
Tachykinins and their functions in the gastrointestinal tract
, 2008 Tachykinins and their functions in the gastrointestinal ...
T Shiina (19188046) +4 more
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Biomarkers for Gastroesophageal Reflux in Respiratory Diseases
Gastroenterology Research and Practice, 2013 Gastroesophageal reflux (GER) is commonly associated with respiratory symptoms, either through a vagal bronchoconstrictive reflex or through microaspiration of gastric contents.
Össur Ingi Emilsson +4 more
doaj +1 more source
Hemokinin-1(4-11)-induced analgesia selectively up-regulates δ-opioid receptor expression in mice.
PLoS ONE, 2014 Our previous studies have shown that an active fragment of human tachykinins (hHK-1(4-11)) produced an opioid-independent analgesia after intracerebroventricular (i.c.v.) injection in mice, which has been markedly enhanced by a δ OR antagonist ...
Cai-Yun Fu +7 more
doaj +1 more source
Physiological mechanisms and therapeutic targets in chronic cough
Physiological Reports, Volume 14, Issue 15, August 2026.Abstract Cough is a vital defensive reflex that safeguards the airways; however, it can become maladaptive and pathological. Chronic cough (>8 weeks in duration) affects up to 10% of the global adult population and is associated with considerable health status impairment. The understanding of cough physiology remains limited.
James C. Brown +3 more
wiley +1 more source
New Roles of Serotonin and Tachykinins in Intestinal Mucositis?
, 2013 New Roles of Serotonin and Tachykinins in Intestinal ...
John Furness (13070439) +1 more
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Primary structures and effects on gastrointestinal motility of tachykinins from the rainbow trout
, 1993 Purification and structural characterization of tachykinins from rainbow trout (Oncorhynchus mykiss) intestine has demonstrated the presence of three different peptides related to the mammalian tachykinins: substance P, neurokinin A, and neuropeptide ...
K. R. Olson, J. Jensen, J. M. Conlon
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Supraspinal Circuit Mechanisms Underlying Itch Processing
CNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.Peripheral pruriceptive signals ascend from the spinal cord to the brainstem, thalamus, and cortex to encode the sensory features of itch. Parallel projections to limbic and basal ganglia circuits mediate affective and motivational components, including aversion and scratching urge.
Yuncheng Luo +3 more
wiley +1 more source