Results 61 to 70 of about 153 (129)

Control of Lipid Metabolism by Tachykinin in Drosophila

Cell Reports, 2014
Summary: The intestine is a key organ for lipid uptake and distribution, and abnormal intestinal lipid metabolism is associated with obesity and hyperlipidemia.
Wei Song, Jan A. Veenstra, Norbert Perrimon   +2 more
doaj   +1 more source

Carcinoid syndrome: update on the pathophysiology and treatment

Clinics, 2018
Approximately 30-40% of patients with well-differentiated neuroendocrine tumors present with carcinoid syndrome, which is a paraneoplastic syndrome associated with the secretion of several humoral factors.
Anezka C. Rubin de Celis Ferrari, João Glasberg, Rachel P. Riechelmann   +2 more
doaj   +1 more source

Airway responsiveness to acetylcholine or capsaicin in immature and mature guinea pigs in vivo

Allergology International, 2000
Non-specific airway hyperresponsiveness is a characteristic feature of bronchial asthma. Airway reactivity to cholinergics may change with age during childhood.
Hirokazu Arakawa, Hiroyuki Mochizuki, Kenichi Tokuyama, Akihiro Morikawa, Jan Lötvall   +4 more
doaj   +1 more source

Gene sequence and related structure of neuropeptides in invertebrates

Invertebrate Survival Journal, 2017
Numerous neuropeptides were studied in different invertebrate species, but the presence of most of them was evaluated only by an immunocytochemical approach using antibodies against the vertebrate homologues. As a consequence, several authors referred to
M Mandrioli, E Ottaviani
doaj  

Decoding the molecular and structural determinants of the neurokinin A and Aβ1-42 peptide cross-interaction in the amyloid cascade pathway

iScience
Summary: Tachykinins are short neuropeptides, such as substance P and neurokinin B, that have been shown to interact with Alzheimer’s β-amyloid (Aβ) peptide.
Mohsen Habibnia, Eric Catalina-Hernandez, Mario Lopez-Martin, David Masnou-Sanchez, Alex Peralvarez-Marin   +4 more
doaj   +1 more source

Effects of TAK-480, a Novel Tachykinin NK2–Receptor Antagonist, on Visceral Hypersensitivity in Rabbits and Ricinoleic Acid–Induced Defecation in Guinea Pigs

Journal of Pharmacological Sciences, 2012
TAK-480, 4-(difluoromethoxy)-N-((1R,2S)-2-(((3aR,4R,9bR)-4-(methoxymethyl)-2, 3,3a,4,5,9b-hexahydro-1H-pyrrolo[3,2-c]quinolin-1-yl)carbonyl)cyclohexyl)benzamide, is a novel tachykinin NK2–receptor antagonist.
Takahiro Tanaka, Akiko Tanaka, Akihiro Nakamura, Kozo Matsushita, Akio Imanishi, Shiho Matsumoto-Okano, Nobuhiro Inatomi, Kasei Miura, Masao Toyoda, Gaku Mizojiri, Yasuhiro Tsukimi   +10 more
doaj   +1 more source

A Chitosan—Based Liposome Formulation Enhances the In Vitro Wound Healing Efficacy of Substance P Neuropeptide

Pharmaceutics, 2017
Currently, there is considerable interest in developing innovative biodegradable nanoformulations for controlled administration of therapeutic proteins and peptides.
Tamara Mengoni, Manuela Adrian, Susana Pereira, Beatriz Santos-Carballal, Mathias Kaiser, Francisco M. Goycoolea   +5 more
doaj   +1 more source

Discovery of defense- and neuropeptides in social ants by genome-mining.

PLoS ONE, 2012
Natural peptides of great number and diversity occur in all organisms, but analyzing their peptidome is often difficult. With natural product drug discovery in mind, we devised a genome-mining approach to identify defense- and neuropeptides in the ...
Christian W Gruber, Markus Muttenthaler
doaj   +1 more source

Functional Characterization of Tachykinin in Regulating Feeding and Energy Metabolism in the Chinese Oak Silkworm, Antheraea pernyi

Insects
Tachykinins (TKs), a conserved family of neuropeptides, play critical roles in regulating multiple physiological processes such as feeding and energy metabolism in insects. This study identified the TK gene (ApTK) from the Chinese oak silkworm, Antheraea
Guobao Wang, Yunhan Zhang, Yong Wang
doaj   +1 more source

The Role of the Arcuate Nucleus in Regulating Hunger and Satiety in Prader-Willi Syndrome

Current Issues in Molecular Biology
Prader-Willi syndrome (PWS) is a rare genetic disorder. The main characteristics are muscular hypotonia, failure to thrive and feeding problems in infancy, which switch to hyperphagia in early childhood and continue into adulthood.
Charlotte Höybye, Maria Petersson
doaj   +1 more source