Results 81 to 90 of about 153 (129)
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Tachykinins in the Respiratory Tract
Current Drug Targets, 2006Tachykinins as substance P and neurokinin A belong to a family of peptides, which are released from airway nerves after noxious stimulation. They influence numerous respiratory functions under both normal and pathological conditions including the regulation of airway smooth muscle tone, vascular tone, mucus secretion and immune functions.
Groneberg DA +4 more
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Immunomodulation by Tachykinin Neuropeptidesa
Annals of the New York Academy of Sciences, 1990Substance P (SP) is an 11-amino-acid neuropeptide found in sensory neurons in the peripheral nervous system. In addition to having well-characterized functions as a peptide neurotransmitter, it also plays a major role in modulating inflammatory and immune responses.
J P, McGillis, M, Mitsuhashi, D G, Payan
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Tachykinins and the Cardiovascular System
Current Drug Targets, 2006The tachykinin family of vasoactive peptides comprises the neuropeptides substance P, neurokinin A and neurokinin B, and the newly discovered endokinins and hemokinins. Their cardiovascular effects are predominantly mediated by the family of neurokinin receptors.
David A, Walsh, Daniel, F McWilliams
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Amphibian tachykinin precursor
Biochemical and Biophysical Research Communications, 2006The precursor of amphibian tachykinin has not been found although more than 30 tachykinins have been isolated from amphibians since 1964. In this report, two tachykinin-like peptides are identified from the skin secretions of the frog, Odorrana grahami.
Jianxu, Li +6 more
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Current Protocols in Pharmacology, 2010
AbstractDescribed in this unit are methods for obtaining, preparing, and testing smooth muscle preparations bearing tachykinin receptors to study the agonist or antagonist properties of test compounds. Concentration‐response curves to agonists are constructed to measure their ability to produce smooth muscle contractions and thus evaluate the potency ...
Stefania, Meini, Carlo Alberto, Maggi
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AbstractDescribed in this unit are methods for obtaining, preparing, and testing smooth muscle preparations bearing tachykinin receptors to study the agonist or antagonist properties of test compounds. Concentration‐response curves to agonists are constructed to measure their ability to produce smooth muscle contractions and thus evaluate the potency ...
Stefania, Meini, Carlo Alberto, Maggi
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Hematopoietic Modulation by the Tachykinins
Acta Haematologica, 2009We have been studying hematopoietic effects by the tachykinins, which like many other neuropeptides can be expressed in neural and nonneural tissues. Substance P (SP) and neurokinin-A (NK-A), members of the tachykinins are immune and hematopoietic modulators.
P, Rameshwar, P, Gascón
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Tachykinin receptors and the airways
Life Sciences, 1991The tachykinins, substance P, neurokinin A and neurokinin B, belong to a structural family of peptides. In mammalian airways, substance P and neurokinin A are colocalized to afferent C-fibres. Substance P-containing fibres are close to bronchial epithelium, smooth muscle, mucus glands and blood vessels.
N, Frossard, C, Advenier
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The mammalian tachykinin receptors
General Pharmacology: The Vascular System, 1995The tachykinins (TKs) are a family of small peptides which share the common C-terminal sequence Phe-X-Gly-Leu-MetNH2. Three peptides of this family, substance P, neurokinin A and neurokinin B, have an established role as neurotransmitters in mammals. 2.
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THE STUDY OF TACHYKININ RECEPTORS
Clinical and Experimental Pharmacology and Physiology, 1989SUMMARY1. Three high affinity receptors (NK1, NK2 and NK3) recognizing the C‐terminal end of tachykinins have been described, with probable endogenous ligands substance P (SP‐), neurokinin A and neurokinin B, respectively.2. Other receptors recognizing the N‐terminal regions of SP exist in adrenal medulla and central nervous system (CNS) with a low ...
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Tachykinin receptors and tachykinin receptor antagonists
Journal of Autonomic Pharmacology, 1993C. A. Maggi +3 more
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