Results 81 to 90 of about 4,888 (209)

Targeting tachykinins for the treatment of obstructive airways disease

, 2004
The tachykinin family of peptides are distributed throughout the nervous system and are thought to play a critical role in inflammation and immunomodulation.
Mazzone, Stuart B.
core   +1 more source

Control of Lipid Metabolism by Tachykinin in Drosophila

Cell Reports, 2014
Summary: The intestine is a key organ for lipid uptake and distribution, and abnormal intestinal lipid metabolism is associated with obesity and hyperlipidemia.
Wei Song, Jan A. Veenstra, Norbert Perrimon   +2 more
doaj   +1 more source

Central tachykinins: mediators of defence reaction and stress reactions

, 1995
The tachykinins substance P, neurokinin A, and neurokinin B are natural agonists for NK1, NK2, and NK3receptors, respectively. Evidence from biochemical, neurophysiological, pharmacological, and molecular biology studies indicates that the tachykinin ...
Thomas Unger, Juraj Culman
core   +1 more source

Carcinoid syndrome: update on the pathophysiology and treatment

Clinics, 2018
Approximately 30-40% of patients with well-differentiated neuroendocrine tumors present with carcinoid syndrome, which is a paraneoplastic syndrome associated with the secretion of several humoral factors.
Anezka C. Rubin de Celis Ferrari, João Glasberg, Rachel P. Riechelmann   +2 more
doaj   +1 more source

Capsaicin-induced release of tachykinins: effects of enzyme inhibitors

, 1991
We studied the effects of neutral endopeptidase (NEP) and angiotensin-converting enzyme (ACE) inhibition on the airway responses and the recovery of endogenously released substance P- and neurokinin A-like immunoreactivities (SP-LI and NKA-LI) after ...
M. A. Martins, S. A. Shore, J. M. Drazen
core   +1 more source

Airway responsiveness to acetylcholine or capsaicin in immature and mature guinea pigs in vivo

Allergology International, 2000
Non-specific airway hyperresponsiveness is a characteristic feature of bronchial asthma. Airway reactivity to cholinergics may change with age during childhood.
Hirokazu Arakawa, Hiroyuki Mochizuki, Kenichi Tokuyama, Akihiro Morikawa, Jan Lötvall   +4 more
doaj   +1 more source

Effects of tachykinins and selective tachykinin receptor agonists on vascular permeability in the rat lower urinary tract: evidence for the involvement of NK-1 receptors

, 1989
Intravenous tachykinins (mammalian and non-mammalian) induced vascular permeability in the rat lower urinary tract. Effects of SP were unaffacted by antihistamine drugs or methysergide. Selective receptor agonists indicated that NK1 receptors mediate the
ASTOLFI M, ABELLI, Luigi, MELI A., CONTE B, MAGGI CA, PARLANI M, ROVERO P, SOMMA V, REGOLI D, Rovero, Paolo   +9 more
core   +1 more source

Gene sequence and related structure of neuropeptides in invertebrates

Invertebrate Survival Journal, 2017
Numerous neuropeptides were studied in different invertebrate species, but the presence of most of them was evaluated only by an immunocytochemical approach using antibodies against the vertebrate homologues. As a consequence, several authors referred to
M Mandrioli, E Ottaviani
doaj  

Decoding the molecular and structural determinants of the neurokinin A and Aβ1-42 peptide cross-interaction in the amyloid cascade pathway

iScience
Summary: Tachykinins are short neuropeptides, such as substance P and neurokinin B, that have been shown to interact with Alzheimer’s β-amyloid (Aβ) peptide.
Mohsen Habibnia, Eric Catalina-Hernandez, Mario Lopez-Martin, David Masnou-Sanchez, Alex Peralvarez-Marin   +4 more
doaj   +1 more source

Behavioural effects of tachykinins and related peptides.

, 2016
Substance P (SP) and related tachykinins administered either intracerebroventricularly or directly into the ventral tegmental area of the mesencephalon of rat brain caused increased locomotor activity, grooming behaviour and wet dog shakes.

core   +1 more source