Results 51 to 60 of about 703,333 (283)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Victory Through Organization: Why the War for Talent is Failing Your Company and What You Can Do About It by Dave Ulrich, David Kryscynski, Mike Ulrich, Wayne Brockbank [PDF]

, 2017
Authors Dave Ulrich, David Kryscynski, Wayne Brockbank and Mike Ulrich’s book released in 2017 — Victory Through Organization: Why the War for Talent is Failing Your Company and What You Can Do About It — offers tools business leaders and HR ...
Sai, M. Ganesh, Sayee, M. Ramakrishna
core   +1 more source

Towards a model of talent development in physical education [PDF]

, 2006
Traditional conceptions of talent generally emphasise the construction of threshold values and the development of relatively unitary abilities, and this approach still dominates talent development programmes for elite sport.
Abbott A., Abernethy B., Bailey R. P., Bailey R. P., Bailey R. P., Bailey R. P., Bailey R. P., Bloom B. S., Bore K., Bouchard C., Brown J., Brustad R. J., Clark A., Colangelo N., Côté J., David Morley, Davis G., De Garay A., Duncan J., Ericsson K.A., Eyre D., Eyre D., Feldman D.H., Freeman J., Freeman J., Freeman J., Gagné F., Gardner H., Gellner E., George D., George D., Grabiner M. D., Gunnell S., Hardman K., Hardman K., Heller F. K. A., Hoare D., Holt N. L., Howe M. J. A., Hymer B., Hymer B., Johnson M., Kalinowski A. G., Kane J. E., Kay T., Keeves J. P., Malina R. M., Marland S. P., Mawer M., Monsaas J. A., Montgomery D., Moore P., Morley D., Morley D., Murdoch E. B., Oakley B., OfSTED, OfSTED, Oyama S., Perleth C., Plomin R., Pühse U., Radford J., Redgrave S., Regnier G., Renzulli J., Renzulli J. S., Richard Bailey, Rotella R. J., Rowley S. R. W., Scarr S., Shermer M., Simonton D., Sloane K., Sloboda J. A., Starkes J. L., Tannenbaum A. J., Tenenbaum G., Tilsley P., Vallerand R. J., VanTassel-Baska J., Ward L., White K., Winner E., Åstrand P. O.   +84 more
core   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Building an Scientific and Technological Talent Database for New Quality Productive Forces [PDF]

Nongye tushu qingbao xuebao
[Purpose/Significance] Talent data have become the most important production factor and strategic resource. Building a scientific and technological (S&T) talent database has become an inevitable way to narrow the digital divide and accelerate the
LI Mengli, WANG Ying, QIAN Li, XIE Jing, CHANG Zhijun, JIA Haiqing
doaj   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

What is the Payoff of HiPo Programs, and Are Companies De-Investing in Them? [PDF]

, 2017
[Excerpt] The average firm spends 27% of its learning and development budget on its high-potential (HiPo) programs, and two-thirds of companies divert budget away from other talent investments to fund HiPo initiatives.
Fitzpatrick, Shannon, Tao, Jiayu
core   +1 more source

A holistic perspective on career development in UK female soccer players: A negative case analysis [PDF]

, 2015
Objectives: The purpose of this study was to examine career experiences of UK-based female youth soccer players from a holistic perspective with a view to producing a grounded theory of factors contributing to career/talent development and transitions in
Adam Gledhill, Blom, Bloor, Bruner, Chris Harwood, Christensen, Christensen, Clarke, Conroy, Corbin, Corbin, Cosh, Creswell, Cropley, Curran, De Haan, Deci, Denzin, Eisenkopf, Erickson, European Commission, Football Association, Fédération Internationale de Football Association, Gill, Gledhill, Goldberg, Guadagnoli, Holt, Holt, Holt, Larsen, Maxwell, Mayan, McCormack, Mills, Morley, Morse, O'Neill, Ommundsen, Patton, Pummell, Quested, Roccas, Rubin, Schwartz, Scott, Semrud-Clikeman, Stambulova, Stambulova, Stambulova, Stambulova, Stambulova, Stambulova, Stambulova, Strauss, Tamminen, Toering, Tracy, Van Yperen, Visek, Weed, Wylleman   +61 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source