Results 41 to 50 of about 8,679,703 (245)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Exploring the association between immune-inflammation index and carotid plaque formation: a cross-sectional study in a large Chinese health screening population

Frontiers in Endocrinology
PurposeCardiovascular disease remains a major public health concern and is closely associated with carotid atherosclerosis, a lipid-driven inflammatory condition.
Jinxiao Sun, Jinxiao Sun, Xialing Zhang, Xialing Zhang, Meng Yang, Meng Yang, Shuo Yang, Shuo Yang, Hua Zeng, Hua Zeng   +9 more
doaj   +1 more source

Developing Talent Management: Saudi Schools as a Case Study

Scientific Journal of King Faisal University: Humanities and Management Sciences, 2021
This study aims at examining the effects of applying talent management approaches by the female principals of public education schools in Yanbu, Saudi Arabia.
Rana Eid Saad Alrifai, Maha Saleh Alamoud   +1 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Employee political skill, leader-member exchange, and promotability: the moderating role of task performance

Frontiers in Psychology
Extant research has identified that employee political skill exerts a positive influence on the formation of high-quality leader-member exchange (LMX), thereby impacting career outcomes.
Congyong Shang, Songlin Chen, Zhidong Li
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Developing a talent management model using government evidence from a large-sized city, Iran

Cogent Business & Management, 2018
The objective of the present research study is to construct a Talent Management model for the public sector from exclusive and inclusive approaches.
Ali Mahfoozi, Sanjar Salajegheh, Mahmoud Ghorbani, Ayoub Sheikhi   +3 more
doaj   +1 more source

Clinical and Modifiable Factors Associated With Disability and Relapse in MOGAD: A Multicentre Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Factors associated with relapse course and disability in myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD) remain incompletely understood. Objectives To identify clinical and modifiable factors associated with relapse and disability in MOGAD. Methods In this ambispective multicentre cohort study using data from
Yingtao Wang, Shaoxin Tao, Qiujia Wang, Xiaoyu Xu, Hui Yao, Zheng Liu, Dawei Li, Zhandong Qiu, Jinming Han, Jiangwei Xia, Qi Wang, Jun Sun, Kai Shao, Jiao Li, Shishuang Ruan, Yi Zhong, Jun Guo, Shougang Guo, Yue Huang, Guoliang Chai, Tao Jin, Hongyu Zhou, Junwei Hao, Yinan Zhao   +23 more
wiley   +1 more source

Conceptualizing and operationalizing 'inclusive' talent management: four different approaches [PDF]

, 2023
In this chapter, we identify four different approaches to inclusive TM - a concept that is increasingly advocated for by both academics and practitioners but has so far lacked clarity and actionability.
Cadigan, Françoise, van Zelderen, Anand, Dries, Nicky   +2 more
core   +1 more source