Results 31 to 40 of about 1,188,882 (284)

Ocrelizumab quantitation by liquid chromatography-tandem mass spectrometry

Journal of Mass Spectrometry and Advances in the Clinical Lab, 2022
Introduction: Ocrelizumab is a monoclonal anti-CD20 antibody approved for the treatment of multiple sclerosis (MS). The clinical value of therapeutic drug monitoring (TDM) for this antibody in treatment of MS is unknown, and an adequately specific and ...
Erik I. Hallin, Trond Trætteberg Serkland, Kjell-Morten Myhr, Øivind Torkildsen, Silje Skrede   +4 more
doaj  

BLINK enables ultrafast tandem mass spectrometry cosine similarity scoring

Scientific Reports, 2023
Metabolomics has a long history of using cosine similarity to match experimental tandem mass spectra to databases for compound identification. Here we introduce the Blur-and-Link (BLINK) approach for scoring cosine similarity.
Thomas V. Harwood, Daniel G. C. Treen, Mingxun Wang, Wibe de Jong, Trent R. Northen, Benjamin P. Bowen   +5 more
doaj   +1 more source

Semi-automated serum steroid profiling with tandem mass spectrometry

Journal of Mass Spectrometry and Advances in the Clinical Lab, 2023
Objectives: Highly selective and sensitive multi-analyte methods for the analysis of steroids are attractive for the diagnosis of endocrine diseases. Commercially available kits are increasingly used for this purpose.
Sophie Rakete, Tom Schubert, Michael Vogeser   +2 more
doaj  

Economics of tandem mass spectrometry screening of neonatal inherited disorders [PDF]

, 2006
Objectives: The aim of this study was to evaluate the cost-effectiveness of neonatal screening for phenylketonuria (PKU) and medium-chain acyl-coA dehydrogenase (MCAD) deficiency using tandem mass spectrometry (tandem MS). Methods: A systematic review
Beverley, C., Chilcott, J., Eastham, J., Paisley, S., Pandor, A.   +4 more
core   +1 more source

An updated map of Trypanosoma cruzi histone post-translational modifications

Scientific Data, 2021
Measurement(s) histone_modification Technology Type(s) mass spectrometry • nanoflow liquid chromatography-tandem mass spectrometry • Data-Dependent Acquisition Sample Characteristic - Organism Trypanosoma cruzi Machine-accessible metadata file describing
Rafael Fogaça de Almeida, Matheus Fernandes, Lyris Martins Franco de Godoy   +2 more
doaj   +1 more source

Gas-Phase Fragmentation of Cyclic Oligosaccharides in Tandem Mass Spectrometry

Molecules, 2019
Modern mass spectrometry, including electrospray and MALDI, is applied for analysis and structure elucidation of carbohydrates. Cyclic oligosaccharides isolated from different sources (bacteria and plants) have been known for decades and some of them ...
Alexander O. Chizhov, Yury E. Tsvetkov, Nikolay E. Nifantiev   +2 more
doaj   +1 more source

Efficacy and outcome of expanded newborn screening for metabolic diseases - Report of 10 years from South-West Germany *

Orphanet Journal of Rare Diseases, 2011
Background National newborn screening programmes based on tandem-mass spectrometry (MS/MS) and other newborn screening (NBS) technologies show a substantial variation in number and types of disorders included in the screening panel.
Mengel Eugen, Trefz Friedrich K, Tacke Uta, Schwab Karl O, Fang-Hoffmann Junmin, Haege Gisela, Gramer Gwendolyn, Lindner Martin, Wendel Udo, Leichsenring Michael, Burgard Peter, Hoffmann Georg F   +11 more
doaj   +1 more source

Analysis of urinary sphingolipids using liquid chromatography‐tandem mass spectrometry in diabetic nephropathy

Journal of Diabetes Investigation, 2020
Aims/Introduction Sphingolipids, such as ceramides and sphingosine, are involved in the pathogenesis of diabetes; however, the modulation of urinary sphingolipids in diabetic nephropathy has not been fully elucidated.
Yoshifumi Morita, Makoto Kurano, Eri Sakai, Takako Nishikawa, Masako Nishikawa, Motoji Sawabe, Junken Aoki, Yutaka Yatomi   +7 more
doaj   +1 more source

Method development and validation of HPLC tandem/mass spectrometry for quantification of perindopril arginine and amlodipine besylate combination in bulk and pharmaceutical formulations

Research in Pharmaceutical Sciences, 2017
A well-characterized and fully validated ultra-high performance liquid chromatography-electrospray ionization-tandem mass spectrometric (UHPLC-ESI-MS/MS) method was developed to reliably analyze combination of perindopril arginine and amlodipine besylate
Kalaiyarasi Duraisamy, K S Jaganathan, Marothu Vamsi krishna   +2 more
doaj   +1 more source

DEIMoS: an open-source tool for processing high-dimensional mass spectrometry data [PDF]

arXiv, 2021
We present DEIMoS: Data Extraction for Integrated Multidimensional Spectrometry, a Python application programming interface (API) and command-line tool for high-dimensional mass spectrometry data analysis workflows that offers ease of development and access to efficient algorithmic implementations.
arxiv