Results 91 to 100 of about 319,008 (372)

Functional Bias and Spatial Organization of Genes in Mutational Hot and Cold Regions in the Human Genome [PDF]

, 2004
The neutral mutation rate is known to vary widely along human chromosomes, leading to mutational hot and cold regions. We provide evidence that categories of functionally-related genes reside preferentially in mutationally hot or cold regions, the size ...
Chuang, Jeffrey H., Li, Hao
core   +5 more sources

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Live cell imaging of low- and non-repetitive chromosome loci using CRISPR-Cas9. [PDF]

, 2017
Imaging chromatin dynamics is crucial to understand genome organization and its role in transcriptional regulation. Recently, the RNA-guidable feature of CRISPR-Cas9 has been utilized for imaging of chromatin within live cells. However, these methods are
Adli, Mazhar, Bandaria, Jigar, Darzacq, Xavier, Kuscu, Cem, Mir, Mustafa, Parlak, Mahmut, Qin, Peiwu, Singh, Ritambhara, Szlachta, Karol, Yildiz, Ahmet   +9 more
core   +1 more source

Sequence Turnover and Tandem Repeats in cis-Regulatory Modules in Drosophila [PDF]

Molecular Biology and Evolution, 2005
The path by which regulatory sequence can change, yet preserve function, is an important open question for both evolution and bioinformatics. The recent sequencing of two additional species of Drosophila plus the wealth of data on gene regulation in the fruit fly provides new means for addressing this question.
Saurabh, Sinha, Eric D, Siggia
openaire   +2 more sources

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Nucleosome positioning on large tandem DNA repeats of the ‘601’ sequence engineered in Saccharomyces cerevisiae [PDF]

, 2021
Astrid Lancrey, Alexandra Joubert, Evelyne Duvernois‐Berthet, Etienne Routhier, Saurabh Raj, Agnès Thierry, Marta Sigarteu, Loı̈c Ponger, Vincent Croquette, Julien Mozziconacci, Jean-Baptiste Boulé   +10 more
openalex   +1 more source

Property differences among the four major Candida albicans strain clades

, 2009
Peer reviewedPublisher ...
Brown, Alistair J P, Castillo, Luis, Gow, Neil A R, MacCallum, Donna M, Munro, Carol A, Nather, Kerstin, Odds, Frank C   +6 more
core   +2 more sources

Identifying Structural Variation in Haploid Microbial Genomes from Short-Read Resequencing Data Using Breseq [PDF]

, 2014
Mutations that alter chromosomal structure play critical roles in evolution and disease, including in the origin of new lifestyles and pathogenic traits in microbes.
Barrick, Jeffrey E., Borges, Jordan J., Colburn, Geoffrey, Deatherage, Daniel E., Knoester, David B., Meyer, Austin G., Reba, Aaron, Strand, Matthew D., Traverse, Charles C.   +8 more
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Extensive genomic rearrangements mediated by repetitive sequences in plastomes of Medicago and its relatives

BMC Plant Biology, 2021
Background Although plastomes are highly conserved with respect to gene content and order in most photosynthetic angiosperms, extensive genomic rearrangements have been reported in Fabaceae, particularly within the inverted repeat lacking clade (IRLC) of
Shuang Wu, Jinyuan Chen, Ying Li, Ai Liu, Ao Li, Mou Yin, Nawal Shrestha, Jianquan Liu, Guangpeng Ren   +8 more
doaj   +1 more source