Results 1 to 10 of about 11,164 (212)

Tanshinone IIA attenuates hepatic stellate cell activation, oxidative stress, and liver fibrosis by inhibiting YAP signaling [PDF]

European Journal of Histochemistry
Tanshinone IIA is derived from Salvia miltiorrhiza and has multiple therapeutic targets and functions. The exact therapeutic effects on liver fibrosis as well as the underlying hepatoprotective mechanisms are still lacking.
Dan Wang, Qingquan Tan, Qing Zheng, Yanling Ma, Li Feng   +4 more
doaj   +2 more sources

Recent advances of tanshinone in regulating autophagy for medicinal research

Frontiers in Pharmacology, 2023
Initially described as an ancient and highly conserved catabolic biofunction, autophagy plays a significant role in disease pathogenesis and progression.
Sha Wu, Sha Wu, Sha Wu, Kui Zhao, Jie Wang, Jie Wang, Jie Wang, Nannan Liu, Nannan Liu, Nannan Liu, Kaidi Nie, Kaidi Nie, Kaidi Nie, Luming Qi, Luming Qi, Luming Qi, Lina Xia, Lina Xia, Lina Xia   +18 more
doaj   +1 more source

Combination prostate cancer therapy: Prostate-specific membranes antigen targeted, pH-sensitive nanoparticles loaded with doxorubicin and tanshinone

Drug Delivery, 2021
Prostate cancer is the second most frequently diagnosed cancer in the men population. Combination anticancer therapy using doxorubicin (DOX) and another extract of traditional Chinese medicine is one nano-sized drug delivery system promising to generate ...
Guanxing Sun, Kai Sun, Jie Sun
doaj   +1 more source

Tanshinone IIA attenuates AOM/DSS-induced colorectal tumorigenesis in mice via inhibition of intestinal inflammation

Pharmaceutical Biology, 2021
Context Tanshinone IIA is a natural extract derived from a Chinese medicinal herb with multiple bioactivities; however, whether and how tanshinone IIA protects against colorectal cancer (CRC) are uncertain.
Lijie Liu, Hanjing Gao, Tao Wen, Tao Gu, Shuang Zhang, Zhiyong Yuan   +5 more
doaj   +1 more source

PPARG is a potential target of Tanshinone IIA in prostate cancer treatment: a combination study of molecular docking and dynamic simulation based on transcriptomic bioinformatics

European Journal of Medical Research, 2023
Tanshinone IIA is a lipophilic organic compound from the root of Danshen (Salvia miltiorrhiza) and is one of the most well-known Tanshinone molecules by pharmacologists.
Tongtong Zhang, Xinglin Chen, Xiran Ju, Jixiang Yuan, Jielong Zhou, Zhihang Zhang, Guanqun Ju, Dongliang Xu   +7 more
doaj   +1 more source

Tanshinone IIA Modulates Low Density Lipoprotein Uptake via Down-Regulation of PCSK9 Gene Expression in HepG2 Cells. [PDF]

PLoS ONE, 2016
Tanshinone IIA, one of the most pharmacologically bioactive phytochemicals isolated from Salvia miltiorrhiza Bunge, possesses several biological activities such as anti-inflammation, anti-cancer, neuroprotection and hypolipidemic activities.
Hung-Chen Chen, Pei-Yi Chen, Ming-Jiuan Wu, Mi-Hsueh Tai, Jui-Hung Yen   +4 more
doaj   +1 more source

Research and Development of Natural Product Tanshinone I: Pharmacology, Total Synthesis, and Structure Modifications

Frontiers in Pharmacology, 2022
Salvia miltiorrhiza (S. miltiorrhiza), which has been used for thousands of years to treat cardiovascular diseases, is a well-known Chinese medicinal plant. The fat-soluble tanshinones in S.
Xing Huang, Lili Jin, Hao Deng, Dan Wu, Qing-kun Shen, Zhe-shan Quan, Chang-hao Zhang, Hong-Yan Guo   +7 more
doaj   +1 more source

Nano-encapsulated tanshinone IIA in PLGA-PEG-COOH inhibits apoptosis and inflammation in cerebral ischemia/reperfusion injury

Green Processing and Synthesis, 2023
Tanshinone IIA has a potential therapeutic effect on cerebral ischemia/reperfusion injury (CIRI). In this study, tanshinone IIA was encapsulated in poly(lactic-co-glycolic acid)-block-poly (ethylene glycol)-carboxylic acid (PLGA-PEG-COOH) nanoparticles ...
Zhang Xin, Zhu Xutong, Huang Lifa, Chen Zupeng, Wang Yuchen, Liu Yajun, Pan Ruihan, Lv Ling   +7 more
doaj   +1 more source

Tanshinone IIA Downregulates Lipogenic Gene Expression and Attenuates Lipid Accumulation through the Modulation of LXRα/SREBP1 Pathway in HepG2 Cells

Biomedicines, 2021
Abnormal and excessive accumulation of lipid droplets within hepatic cells is the main feature of steatosis and nonalcoholic fatty liver disease (NAFLD) or metabolic-associated fatty liver disease (MAFLD).
Wan-Yun Gao, Pei-Yi Chen, Hao-Jen Hsu, Ching-Yen Lin, Ming-Jiuan Wu, Jui-Hung Yen   +5 more
doaj   +1 more source

Tanshinone Ameliorates Glucocorticoid-Induced Bone Loss via Activation of AKT1 Signaling Pathway

Frontiers in Cell and Developmental Biology, 2022
Purpose: Osteoporosis, a common disorder especially prevalent in the postmenopausal women and the elderly, is becoming a worldwide public health problem.
Yanjun Wang, Lin Liu, Zechao Qu, Dong Wang, Wangli Huang, Lingbo Kong, Liang Yan   +6 more
doaj   +1 more source