Frontiers in Plant Science, 2023 The roots of Salvia miltiorrhiza are the source of the traditional Chinese medicine danshen and the class of tanshinones, particular quinoid nor-diterpenoids of the abietane type.
Arpine Ayvazyan +7 more
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Effects of tanshinone on hyperandrogenism and the quality of life in women with polycystic ovary syndrome: protocol of a double-blind, placebo-controlled, randomised trial. [PDF]
, 2013 published_or_final_versio
Cong, J +6 more
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Metabolism of Tanshinone IIA, Cryptotanshinone and Tanshinone I from Radix Salvia Miltiorrhiza in Zebrafish [PDF]
Molecules, 2012 The study aimed to investigate the potential of zebrafish in imitating mammal phase I metabolism of natural compounds. Three diterpenoid quinones from Radix Salvia miltiorrhiza, namely tanshinone IIA (TIIA), cryptotanshinone (Cry) and tanshinone I (TI) were selected as model compounds, and their metabolites mediated by zebrafish were characterized ...
Bing Wang +7 more
openaire +3 more sources
Tissue-smashing based ultra-rapid extraction of chemical constituents in herbal medicines [PDF]
, 2014 postprin
Chen, C +5 more
core +1 more source
Interfering with HuR-RNA Interaction: Design, Synthesis and Biological Characterization of Tanshinone Mimics as Novel, Effective HuR Inhibitors [PDF]
, 2018 The human antigen R (HuR) is an RNA-binding protein known to modulate the expression of target mRNA coding for proteins involved in inflammation, tumorigenesis, and stress responses and is a valuable drug target.
Baj, Vanessa +18 more
core +2 more sources
What Does It Take to Synergistically Combine Sub-Potent Natural Products into Drug-Level Potent Combinations? [PDF]
, 2012 10.1371/journal.pone.0049969PLoS ...
A Sivachenko +63 more
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Molecules, 2022 The present study characterizes the 5′ regulatory region of the SmMEC gene. The isolated fragment is 1559 bp long and consists of a promoter, 5′UTR and 31 nucleotide 5′ fragments of the CDS region. In silico bioinformatic analysis found that the promoter
Piotr Szymczyk +4 more
doaj +1 more source
The mechanisms of tanshinone in the treatment of tumors
Frontiers in Pharmacology, 2023 Tanshinone is a lipophilic compound that is present in traditional Chinese medicine and is derived from the roots of Salvia miltiorrhiza (Danshen). It has been proven to be highly effective in combating tumors in various parts of the body, including ...
Pengyu Zhang, Wendi Liu, Yuan Wang
doaj +1 more source
Studies on polynuclear furoquinones. Part 1: Synthesis of tri- and tetra-cyclic furoquinones simulating BCD/ABCD ring system of furoquinone diterpenoids [PDF]
, 2009 Synthesis of phenanthro[1,2-b]furan-10,11-dione, the core nucleus present in Tanshinone-I is described in 8–10 steps starting from 2-bromo-3,4-dihydro-1-naphthaldehyde. The bromoaldehyde was converted to methyl 2-(2-bromo-1-naphthyl)acetate or 2-(2-bromo-
Fang +8 more
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Frontiers in Plant Science, 2022 Red sage, the dry root and rhizome of the herbaceous plant Salvia miltiorrhiza Bunge, is widely used for treating various diseases. The low content of tanshinones (terpenoids) has always restricted development of the S. miltiorrhiza industry.
Da-chuan Zhang +10 more
doaj +1 more source