Results 41 to 50 of about 11,164 (212)

A Biomedical Investigation of the Hepatoprotective Effect of Radix salviae miltiorrhizae and Network Pharmacology-Based Prediction of the Active Compounds and Molecular Targets [PDF]

, 2017
published_or_final_versio
Cheung, F, Feng, Y, HONG, M, LI, S, Tan, HY, Wang, N   +5 more
core   +4 more sources

A Zebrafish Compound Screen Reveals Modulation of Neutrophil Reverse Migration as an Anti-Inflammatory Mechanism [PDF]

, 2014
Diseases of failed inflammation resolution are common and largely incurable. Therapeutic induction of inflammation resolution is an attractive strategy to bring about healing without increasing susceptibility to infection.
Anderson, S.R., Bojarczuk, A.N., Burgon, J., Chimen, M., Coles, M.C., Farrow, S.N., Hamza, B., Holmes, G.R., Irimia, D., Jones, S., Kadirkamanathan, V., Loynes, C.A., Prince, L.R., Rainger, G.E., Renshaw, S.A., Robertson, A.L., Sawtell, A.K., Solari, R., Walmsley, S.R., Whyte, M.K.B., Willson, J.   +20 more
core   +1 more source

Sodium Tanshinone IIA Sulfonate Attenuates Tumor Oxidative Stress and Promotes Apoptosis in an Intermittent Hypoxia Mouse Model

Technology in Cancer Research & Treatment, 2020
Objective: Intermittent hypoxia, a significant feature of obstructive sleep apnea, has pro-tumorigenic effects. Here, we investigated the effect of sodium tanshinone IIA sulfonate on oxidative stress and apoptosis in a mouse model of Lewis lung carcinoma
Xiao-Bin Zhang PhD, Xiao-Yang Chen PhD, Peng Sun MD, Xiao-Man Su Nurse, Hui-Qing Zeng PhD, Yi-Ming Zeng PhD, Miao Wang MD, Xiongbiao Luo PhD   +7 more
doaj   +1 more source

Preclinical and clinical examinations of Salvia miltiorrhiza and its tanshinones in ischemic conditions [PDF]

, 2006
Salvia miltiorrhiza (Labiatae, Laminaceae), danshen, is an annual sage mainly found in China and neighboring countries. The crude drug (dried root) and its preparations are currently used in China to treat patients suffering from heart attack, angina ...
Lien Eric, Yang Jun, Wang Rubin, Adams James   +3 more
core   +1 more source

Preparation and characterisation of solid dispersions of tanshinone IIA, cryptotanshinone and total tanshinones

Asian Journal of Pharmaceutical Sciences, 2017
Total tanshinones are lipophilic active constituents extracted from Salvia miltiorrhiza Bge. Tanshinone IIA and cryptotanshinone are the major components in total tanshinones. However, the bioavailability of both compounds is low due to poor water solubility.
Zhai, Xifeng, Li, Chunguang, Lenon, George Binh, Xue, Charlie C.L., Li, Weize   +4 more
openaire   +4 more sources

Tanshinone IIA ameliorates non-alcoholic fatty liver disease through targeting peroxisome proliferator-activated receptor gamma and toll-like receptor 4

Journal of International Medical Research, 2019
Objective To investigate the cellular mechanisms of action of tanshinone IIA on the fatty liver disease induced by a high-fat diet in an animal model of non-alcoholic fatty liver disease (NAFLD).
Lu Huang, Wei Ding, Ming-Qiang Wang, Zheng-Gen Wang, Hong-Hui Chen, Wen Chen, Qiong Yang, Ting-Na Lu, Qing Yang, Ji-Man He   +9 more
doaj   +1 more source

Efficacy of tanshinone IIA in rat models with myocardial ischemia–reperfusion injury: a systematic mini-review and meta-analysis [PDF]

PeerJ
Background Myocardial ischemia–reperfusion injury (MIRI) refers to severe damage to the ischemic myocardium following the restoration of blood flow, and it is a major complication of reperfusion therapy for myocardial infarction.
Xiaobin Zhang, Hehe Jiang, Linlin Zhang, Chen Chen, Mengzhen Xing, Dongqing Du, Yujie Li, Yuning Ma, Yuxia Ma, Chunjing Li   +9 more
doaj   +2 more sources

Genome-wide identification and characterization of Dof gene family in Salvia miltiorrhiza

Ornamental Plant Research
Salvia miltiorrhiza is an important medicinal plant, and its main secondary metabolites are tanshinones and phenolic acids. Dof transcription factors play an irreplaceable role in regulating plant growth and secondary metabolism.
Xinyu Wang, Qichao Wang, Siyu Hao, Jianjun Zhu, Guoyin Kai, Wei Zhou   +5 more
doaj   +1 more source

Mechanism of lncRNA JPX targeting miR-378 in tanshinone ⅡA affecting proliferation, cloning and apoptosis in colon cancer SW620 cells

Di-san junyi daxue xuebao, 2021
Objective To study the mechanism of lncRNA JPX targeting miR-378 in the proliferation, cloning and apoptosis of colon cancer SW620 cells induced by tanshinone ⅡA.
QIAN Jun, CAO Yi, LI Lingchang, YU Jialin, HUO Jiege   +4 more
doaj   +1 more source

Tanshinone IIA: A Promising Natural Cardioprotective Agent [PDF]

Evidence-Based Complementary and Alternative Medicine, 2012
Tanshinone IIA (Tan IIA) is a member of the major lipophilic components extracted from the root ofSalvia miltiorrhizaBunge, which is currently used in China and other neighboring countries to treat patients suffering from myocardial infarction (MI), angina pectoris, stroke, diabetes, sepsis, and other conditions.
Shang, Qinghua, Xu, Hao, Huang, Li
openaire   +2 more sources