Results 171 to 180 of about 21,115,427 (202)

Simultaneous determination of danshensu, rosmarinic acid, cryptotanshinone, tanshinone IIA, tanshinone I and dihydrotanshinone I by liquid chromatographic–mass spectrometry and the application to pharmacokinetics in rats

Journal of Pharmaceutical and Biomedical Analysis, 2010
A sensitive and specific liquid chromatography-tandem mass spectrometry method (LC-MS) was developed and validated for the separation and simultaneous determination of danshensu, rosmarinic acid and tanshinone compounds including cryptotanshinone, tanshinone I, dihydrotanshinone I and tanshinone IIA in rat plasma.
Yun, Liu, Xiaorong, Li, Yuhang, Li, Lijuan, Wang, Ming, Xue   +4 more
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Identification of tanshinone I as a natural Cu(II) ionophore

Free Radical Biology and Medicine
The development of Cu(II) ionophores for targeted disruption of aberrant redox homeostasis in cancer cells has been considered an appealing strategy in the field of anticancer research. This study presents the first identification of tanshinone I (Ts1), a natural o-quinone, as a Cu(II) ionophore.
Ya-Long, Zheng, Yuan, Ji, Yan, Li, Shuai, Yan, Xiao-Rong, Ren, Wei, Tang, Fang, Dai, Bo, Zhou   +7 more
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Protective properties of tanshinone I against oxidative DNA damage and cytotoxicity

Food and Chemical Toxicology, 2013
Tanshinone I, a naturally occurring diterpene from Danshen, has been shown to possess hepatocyte protective, anticancer, and memory enhancing properties. However, there are few stringent pharmacological tests for neuroprotection of tanshinone I thus far.
Shimiao, Zhou, Wei, Chen, Hongming, Su, Xiaodong, Zheng   +3 more
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DNA methylation controls the expression of tanshinone synthesis genes and the tanshinone accumulation in Salvia miltiorrhiza and Salvia bowleyana

The Plant Journal
SUMMARY DNA methylation plays pivotal roles in regulating gene expression and the secondary metabolism in plants. Salvia miltiorrhiza and Salvia bowleyana are traditional Chinese medicinal plants with roots enriched with tanshinone ...
Li‐Wei Liu, Xin‐Ru Du, Rui Chu, Xin‐Yu He, Yi‐Wen Chen, Hua‐Qian You, Itezaz Younas, Yi‐Hong Li, Wei Li, Rui Zhang, Ye‐Long Sheng, Ming Zhou, Qi Cui, Zong‐Suo Liang, Dong‐Feng Yang   +14 more
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Tanshinone I induces apoptosis and pro-survival autophagy in gastric cancers

Cancer Chemotherapy and Pharmacology, 2016
To investigate the occurrence of apoptosis and autophagy on human gastric cancer cells after treatment by Tanshinone I, as well as the relationship between them.BGC823 and SGC7901 cells were treated with Tanshinone I; the cell proliferation was measured using CCK-8 and clone formation assay; and the expression of apoptosis- and autophagy-associated ...
Xiaoping, Jing, Yichun, Xu, Weiwei, Cheng, Sheng, Guo, Ya, Zou, Li, He   +5 more
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Absorption mechanism of tanshinoneⅡA, cryptotanshinone, tanshinone I and tanshinones extract in rat small intestine in vivo

China Journal of Chinese Materia Medica, 2010
OBJECTIVE To study the absorption mechanism of tanshinones in the roots of Salvia miltiorrhiza as well as the interaction between the components in the effective fraction. METHOD The model of intestinal absorption in vivo was used and the concentrations of the tanshinones were determined by HPLC, the apparent absorption constant (K(a)) and half life of
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The Effect of Tanshinone IIA on the Cardiovascular System in Ovine Fetus in Utero

The American Journal of Chinese Medicine, 2009
This was the first study to determine the effect of tanshinone IIA (an active ingredient in herb Danshen) on fetuses in utero under unstressed condition. Tanshinone IIA or 0.9% NaCl as control was intravenously (i.v.) administrated into pregnant ewes.
Caiping, Mao, Yifan, Zhang, Yuying, Zhang, Li, Cao, Huan, Shao, Liping, Wang, Liyan, Zhu, Zhice, Xu   +7 more
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Tanshinone II-A inhibits low density lipoprotein oxidationin vitro

Free Radical Research, 2000
Tanshinone II-A (TSII-A) is a major component of Salvia miltorrhiza Bunge which has long been used for preventing and ameliorating anginal pain in China. However the effect of TSII-A on low density lipoprotein (LDL) oxidation has not been studied. The present study was performed to investigate the effects of TSII-A on LDL oxidation using four oxidizing
X L, Niu, K, Ichimori, X, Yang, Y, Hirota, K, Hoshiai, M, Li, H, Nakazawa   +6 more
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Tanshinone I attenuates proliferation and chemoresistance of cervical cancer in a KRAS‐dependent manner 

Journal of Biochemical and Molecular Toxicology, 2018
AbstractChemoresistance is a common occurrence during advanced or recurrent cervical cancer therapy when treated by conventional treatment, platinum‐based chemotherapy. This study aimed to investigate the effect and underlying mechanism of tanshinone I on attenuating proliferation and chemoresistance of cervical cancer cells.
Sidi Dun, Lan Gao
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Inhibition of Mast Cell Degranulation by Tanshinones from the Roots ofSalvia miltiorrhiza

Planta Medica, 1999
The activity-guided fractionation of the extract of the root of Salvia miltiorrhiza B. (Labiatae, Tanshen), led to the isolation of four active components responsible for the anti-allergic activity in vitro. Among them, 15,16-dihydrotanshinone-I and cryptotanshinone demonstrated significant inhibition of the release of beta-hexosaminidase from cultured
S Y, Ryu, M H, Oak, K M, Kim
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