Results 71 to 80 of about 2,942 (199)

Glycolysis enzymes and cellular lactylation in tumour

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
Graphical Headlights • Glycolytic enzymes regulate lactylation in cancer cells. • Lactylation drives tumour growth, metastasis, immune evasion and contributes to microenvironment remodelling. • Targeting lactylation holds promise for cancer therapy. Abstract Cellular lactylation, a recently identified post‐translational modification, has emerged as a ...
Chenyuan Dai, Lihua Wang
wiley   +1 more source

Ginsenoside Rg1 as a Multifunctional Therapeutic Agent: Pharmacological Properties, Molecular Mechanisms and Clinical Perspectives in Complementary Medicine

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Ginsenoside Rg1 (Rg1) from Panax ginseng shows multifunctional health effects. Although oral bioavailability is low and blood–brain barrier (BBB) penetration is limited, delivery systems such as liposomes and nanoparticles may improve exposure. Rg1 reduces inflammation/oxidative stress by inhibiting nuclear factor‐κB (NF‐κB) signaling and reactive ...
Hernán Cortés, Enrique Lima, Lorena Duarte‐Peña, Sheila I. Peña‐Corona, Zainab M. Almarhoon, Rajesh Kaverikana, Shivaprasad Shetty Mangalpady, Vinayaka Babu Shet, Nikshitha Manjeshwar, Javad Sharifi‐Rad, Jen‐Tsung Chen, Gerardo Leyva‐Gómez, William N. Setzer, Daniela Calina   +13 more
wiley   +1 more source

Atlas‐Based Mapping of Traditional Chinese Medicine Effects on Tumor Microcirculation Regulation

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
ABSTRACT Background Tumor microcirculation plays a central role in the onset and progression of hypoxia, therapeutic resistance, and immune evasion within the tumor microenvironment. Traditional Chinese Medicine (TCM), characterized by its multi‐targeted and systemic regulatory properties, has garnered increasing attention for its potential to modulate
I Ho, Yijie Xie, Zhipeng Liu, Dingjun Cai   +3 more
wiley   +1 more source

Pharmacological basis of tanshinone and new insights into tanshinone as a multitarget natural product for multifaceted diseases

Biomedicine & Pharmacotherapy, 2020
Drug development has long included the systematic exploration of various resources. Among these, natural products are one of the most important resources from which novel agents are developed due to the multiple pharmacologic effects of these natural products on diseases. Tanshinone, a representative natural product, is the main compound extracted from
Zhibei, Li, Jing, Zou, Dan, Cao, Xiao, Ma   +3 more
openaire   +2 more sources

Transcription Factor SmWRKY1 Positively Promotes the Biosynthesis of Tanshinones in Salvia miltiorrhiza

Frontiers in Plant Science, 2018
Tanshinones, one group of bioactive diterpenes, were widely used in the treatment of cardiovascular diseases. WRKYs play important roles in plant metabolism, but their regulation mechanism in Salvia miltiorrhiza remains elusive.
Wenzhi Cao, Yao Wang, Min Shi, Xiaolong Hao, Weiwei Zhao, Yu Wang, Jie Ren, Guoyin Kai, Guoyin Kai   +8 more
doaj   +1 more source

Equality-evaluation of Wakan-yaku (Japanese-Chinese traditional medicines) with liquid chromatography-mass spectrometry (LC-MS) : comparison of constituents of original plants for Chinese traditional medicine "Dan-shen (Tan-j in)" [PDF]

, 2001
Wakan-yaku (Japanese-Chinese traditional medicines) are natural products and its constituents and/or activities depend on several factors, such as species, timing of collection, producing area, individual, etc.
Tezuka Yasuhiro
core   +1 more source

Natural Products in Cancer Prevention and Therapy: Current Challenges and Future Directions

MedComm, Volume 7, Issue 2, February 2026.
Natural products play a pivotal role in cancer therapy. They induce cancer cell death by reprogramming four metabolic pathways while precisely targeting the tumor microenvironment and immune cells. These compounds not only leverage novel delivery systems for innovative applications but also demonstrate unique therapeutic efficacy across clinical stages:
Ruimiao Qian, Jun Ge, Ni Fan, Zheng Sun, Chengcheng Zhao, Yujiao Sun, Yingpeng Li, Yunfei Li, Hui Fu   +8 more
wiley   +1 more source

Traditional Chinese Medicine Modernization in Diagnosis and Treatment: Utilizing Artificial Intelligence and Nanotechnology

MedComm, Volume 7, Issue 2, February 2026.
Traditional Chinese medicine (TCM) faces great challenges during the development of modern medicine. Utilizing novel technologies such as artificial intelligence (AI) and nanotechnology facilitates TCM with great potential in precision diagnosis and improved treatments efficacy.
Wenqi Yu, Mengzhen Chen, Xueqi Tan, Xi Wei, Fan Sun, Hua Yan, Xue Xu, Hongcai Shang   +7 more
wiley   +1 more source

Correlations between SmCPS1 promoter polymorphism and tanshinone contents in Salvia miltiorrhiza

Czech Journal of Genetics and Plant Breeding, 2018
Copalyl diphosphate synthase 1 (SmCPS1) is the first committed enzyme in tanshinone biosynthesis. The promoter region plays an important role in the transcriptional regulation of genes.
Ying SUN, Xin CHEN, Xiao-Yan GAN, Zhu-Yun YAN, Di-Xiu MU, Qing-Rong WANG   +5 more
doaj   +1 more source

Solid Dispersions as a Tool for Innovation in the Food Industry: A Path From Pharma to Food

Journal of Food Science, Volume 91, Issue 2, February 2026.
ABSTRACT Solid dispersion (SD) is a technique used to improve the solubility of poorly water‐soluble compounds by dispersing them in a solid water‐friendly carrier. Current trends indicate that natural‐based alternatives are increasingly replacing synthetic carriers, benefiting the pharmaceutical industry, where they were first adopted, and paving the ...
Stephany C. de Rezende, Arantzazu Santamaria‐Echart, Madalena M. Dias, Maria Filomena Barreiro   +3 more
wiley   +1 more source