Results 81 to 90 of about 2,942 (199)

Tanshinone IIA sodium sulfonate facilitates endocytic HMGB1 uptake [PDF]

Biochemical Pharmacology, 2012
Our seminal discovery of high mobility group box 1 (HMGB1) as a late mediator of lethal systemic inflammation has prompted a new field of investigation for the development of experimental therapeutics. We previously reported that a major Danshen ingredient, tanshinone IIA sodium sulfonate (TSN-SS), selectively inhibited endotoxin-induced HMGB1 release ...
Yusong, Zhang, Wei, Li, Shu, Zhu, Arvin, Jundoria, Jianhua, Li, Huan, Yang, Saijun, Fan, Ping, Wang, Kevin J, Tracey, Andrew E, Sama, Haichao, Wang   +10 more
openaire   +2 more sources

Interfering with HuR-RNA Interaction: Design, Synthesis and Biological Characterization of Tanshinone Mimics as Novel, Effective HuR Inhibitors [PDF]

, 2018
The human antigen R (HuR) is an RNA-binding protein known to modulate the expression of target mRNA coding for proteins involved in inflammation, tumorigenesis, and stress responses and is a valuable drug target.
Baj, Vanessa, Biasini, Emiliano, Bonomo, Isabelle, Brambilla, Marta, Cerofolini, Linda, D'Agostino, Vito G, Elezgarai, Saioa, Fragai, Marco, Lal, Preet, Luchinat, Claudio, Maio, Danilo Di, Manzoni, Leonardo, Marinelli, Luciana, Miceli, Marco, Novellino, Ettore, Provenzani, Alessandro, Seneci, Pierfausto, Thongon, Natthakan, Zucal, Chiara   +18 more
core   +2 more sources

Enhancing Metabolic Engineering in Medicinal Plants Through Prime Editing

Plant Biotechnology Journal, EarlyView.
Haomiao Yu, Xiao Feng, Xiaohang Zheng, Xiao Wang, Wenxin Zheng, Zhizhou Zhang, Yuanyuan Jiang, Ruiwu Yang, Li Zhang, Zhaohui Zhong   +9 more
wiley   +1 more source

Adjunctive Therapies in Periodontitis: Current Concepts and the Future

Journal of Periodontal Research, Volume 61, Issue 2, Page 138-164, February 2026.
This graphical abstract summarizes the translational pathway from preclinical research to clinical implementation of adjunctive therapies for periodontitis, highlighting key barriers, innovative therapeutic strategies, and emerging tools that aim to bridge experimental discoveries with patient care.
Rafael Scaf de Molon, Joao Paulo Steffens, Erica Dorigatti de Avila, Wim Teughels, Thomas E. Van Dyke   +4 more
wiley   +1 more source

Tanshinone IIA pretreatment attenuates hepatic ischemia-reperfusion

Frontiers in Bioscience, 2012
Tanshinone IIA (Tan IIA), an active component derived from Salvia miltiorrhiza root, has been used to treat various ischemic cardiovascular and cerebrovascular diseases. However, its impact on hepatic ischemia/reperfusion (I/R) injury remains unclear. Here, we addressed this issue by using a 90-minute partial liver ischemia model.
Yan-yan, Qi, Liang, Xiao, Lu-ding, Zhang, Shao-hua, Song, Yi, Mei, Teng, Chen, Jian-ming, Tang, Fang, Liu, Guo-shan, Ding, Yong-zhao, Shi, Quan-xing, Wang   +10 more
openaire   +2 more sources

Transcriptome and yeast two-hybrid sequencing shed light on the crosstalk between light and jasmonate signaling in regulating tanshinone biosynthesis

Medicinal Plant Biology
As a high-value active component in Salvia miltiorrhiza (Danshen), the accumulation of tanshinones is under the influence of various environmental factors, yet it is unknown whether light, as an essential environmental factor for plant growth, regulates ...
Han Zheng, Xueqing Fu, Muyao Yu, Qi Liu, Chenyi Li, Ling Li, Shuyi Qian, Kang Chen, Shuncang Zhang, Kexuan Tang, Luqi Huang   +10 more
doaj   +1 more source

Production of Salvianolic Acid B in Roots of Salvia miltiorrhiza (Danshen) During the Post-Harvest Drying Process

Molecules, 2012
Drying is the most common and fundamental procedure in the post-harvest processing which contributes to the quality and valuation of medicinal plants. However, attention to and research work on this aspect is relatively poor.
Guo-Jun Zhou, Xiao-Mei Xie, Tong-Shui Zhou, Xiao-Bing Li, Yan Li, Wei Wang   +5 more
doaj   +1 more source

Neurocognitive improvement through plant food bioactives: A particular approach to Alzheimer's disease [PDF]

, 2017
Alzheimer’s disease (AD) is currently one of the most prevalent neurodegenerative disorders, directly related to increasing rates of morbidity and autonomy impairment between worldwide citizens. Social and demographical changes are direct contributors;
Ferreira, Isabel C.F.R., Martins, Natália   +1 more
core   +1 more source

Effects of the coexisting diterpenoid tanshinones on the pharmacokinetics of cryptotanshinone and tanshinone IIA in rat

European Journal of Pharmaceutical Sciences, 2007
Tanshinone II(A) and cryptotanshinone are the main pharmacologically active components in the Chinese herb drug Salvia miltiorrhiza Bge. The objective of this study was to investigate the effect of coexisting tanshinones in liposoluble ethanol extract of S. miltiorrhiza Bge.
Min, Song, Tai-Jun, Hang, Zhengxing, Zhang, Hong-Yuan, Chen   +3 more
openaire   +2 more sources

Rosmarinic Acid Synthase 1 Phosphorylation by SmMAPK3 Is Required for Salicylic Acid‐Induced Salvianolic Acid Accumulation in Salvia miltiorrhiza Hairy Roots

Plant Biotechnology Journal, Volume 24, Issue 2, Page 734-751, February 2026.
ABSTRACT Salvianolic acid is the main active component of Salvia miltiorrhiza and holds significant value in the clinical treatment of myocardial ischemia and hypoxia. Previous studies have shown that salicylic acid (SA) can significantly promote the accumulation of salvianolic acid, but its molecular mechanism remains incompletely understood.
Xuecui Yin, Shuang Liu, Yuhang Zhang, Wenjing Yang, Junwen Bu, Bin Zhang, Juane Dong   +6 more
wiley   +1 more source