Results 71 to 80 of about 7,670,364 (343)

Targeted Metabolomics Data

, 2023
targeted metabolomics analysis of the fetal lungs, in a delayed labor mouse model, steroid receptor coactivator (SRC)1/SRC2 double knockout (dKO) mouse.
Xuesong Sui (15206344)
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Remarkable impact of commercial sterilizing on ginsenosides transformation in fresh ginseng pulp based on widely targeted metabolomics analysis

Food Chemistry: X, 2022
Highlights • Changes of terpenoids in SGP were identified by widely targeted metabolomics.• 88 terpenoids compounds including 30 types of ginsenosides were changed in SGP.• Conversion mechanism of ginsenosides during commercial sterilization was ...
Jun-Shun Zhang, Zhiyi Ai, Yue Hu, Yong-Hong Wang, Sitong Liu, Yongzhe Liu, Bo Nan, Yu-Hua Wang   +7 more
semanticscholar   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Bridging Targeted and Untargeted Mass Spectrometry-Based Metabolomics via Hybrid Approaches

Metabolites, 2020
This mini-review aims to discuss the development and applications of mass spectrometry (MS)-based hybrid approaches in metabolomics. Several recently developed hybrid approaches are introduced.
Li Chen, Fanyi Zhong, Jiangjiang Zhu
doaj   +1 more source

Benchmarking Non-Targeted Metabolomics Using Yeast-Derived Libraries

Metabolites, 2021
Non-targeted analysis by high-resolution mass spectrometry (HRMS) is an essential discovery tool in metabolomics. To date, standardization and validation remain a challenge. Community-wide accepted cost-effective benchmark materials are lacking.
Evelyn Rampler, Gerrit Hermann, Gerlinde Grabmann, Yasin El Abiead, Harald Schoeny, Christoph Baumgartinger, Thomas Köcher, Gunda Koellensperger   +7 more
doaj   +1 more source

Comparative Characterization of Key Volatile Compounds in Slow- and Fast-Growing Duck Raw Meat Based on Widely Targeted Metabolomics

Foods, 2022
The volatile aroma compounds in raw duck meat strongly affect consumers’ purchase decisions and they vary among breeds with different growth rates. In this study, slow-growing (SG) Liancheng White and fast-growing (FG) Cherry Valley ducks were selected ...
Kai-Qi Weng, Li-Na Song, Q. Bao, Zhengfeng Cao, Yu Zhang, Yang Zhang, Guo-Hong Chen, Qi Xu   +7 more
semanticscholar   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Gamma-ray Irradiation of Rodent Diets Alters the Urinary Metabolome in Rats with Chemically Induced Mammary Cancer

Metabolites, 2022
In this study, a comparative, untargeted metabolomics approach was applied to compare urinary metabolite profiles of rats fed irradiated and non-irradiated diets.
Jeevan K. Prasain, Landon S. Wilson, Clinton Grubbs, Stephen Barnes   +3 more
doaj   +1 more source

Matching Drug Metabolites from Non-Targeted Metabolomics to Self-Reported Medication in the Qatar Biobank Study

Metabolites, 2022
Modern metabolomics platforms are able to identify many drug-related metabolites in blood samples. Applied to population-based biobank studies, the detection of drug metabolites can then be used as a proxy for medication use or serve as a validation tool
K. Suhre, Nisha Stephan, S. Zaghlool, C. Triggle, Richard J Robinson, A. M. Evans, A. Halama   +6 more
semanticscholar   +1 more source