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Frontiers in Bioscience-Landmark, 2023 Background: Pyroptosis plays a crucial role in anti-tumor immunity and in formation of the immune microenvironment. However, whether pyroptosis is involved in the progression of clear cell renal cell carcinoma (ccRCC) is still unclear.
Jinpeng Ma +12 more
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Frontiers in Oncology, 2022 Radiotherapy is one of the most effective and frequently used treatments for a wide range of cancers. In addition to its direct anti-cancer cytotoxic effects, ionising radiation can augment the anti-tumour immune response by triggering pro-inflammatory ...
Charleen M. L. Chan Wah Hak +5 more
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Advancements in clinical aspects of targeted therapy and immunotherapy in breast cancer
Molecular Cancer, 2023 Breast cancer is the second leading cause of death for women worldwide. The heterogeneity of this disease presents a big challenge in its therapeutic management.
Feng Ye +9 more
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Targeted cancer therapies [PDF]
Chinese Journal of Cancer, 2011 With unprecedented understanding of molecular events underlying human cancer in this genomic era, a large number of drugs specifically targeting hypothesized oncogenic drivers to which tumors are potentially addicted to have been developed and continue to be developed.
Yan, Li, Rosen, Neal, Arteaga, Carlos
openaire +2 more sources
Recent advances in non-small cell lung cancer targeted therapy; an update review
Cancer Cell International, 2023 Lung cancer continues to be the leading cause of cancer-related death worldwide. In the last decade, significant advancements in the diagnosis and treatment of lung cancer, particularly NSCLC, have been achieved with the help of molecular translational ...
M. Araghi +10 more
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Liposomes for Tumor Targeted Therapy: A Review
International Journal of Molecular Sciences, 2023 Liposomes, the most widely studied nano-drug carriers in drug delivery, are sphere-shaped vesicles consisting of one or more phospholipid bilayers. Compared with traditional drug delivery systems, liposomes exhibit prominent properties that include ...
Shile Wang +3 more
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Engineered exosomes from different sources for cancer-targeted therapy
Signal Transduction and Targeted Therapy, 2023 Exosome is a subgroup of extracellular vesicles, which has been serving as an efficient therapeutic tool for various diseases. Engineered exosomes are the sort of exosomes modified with surface decoration and internal therapeutic molecules.
Menghui Zhang +7 more
semanticscholar +1 more source
Ursodeoxycholic acid suppresses the malignant progression of colorectal cancer through TGR5-YAP axis
Cell Death Discovery, 2021 The Hippo/YAP pathway plays an important role in the development of cancers. Previous studies have reported that bile acids can activate YAP (Yes Associated Protein) to promote tumorigenesis and tumor progression.
Huan Zhang +4 more
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Signaling pathways in rheumatoid arthritis: implications for targeted therapy
Signal Transduction and Targeted Therapy, 2023 Rheumatoid arthritis (RA) is an incurable systemic autoimmune disease. Disease progression leads to joint deformity and associated loss of function, which significantly impacts the quality of life for sufferers and adds to losses in the labor force.
Qian Ding +9 more
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Cell Death Discovery, 2021 Lipid homeostasis plays a fundamental role in the development of hepatocellular carcinoma (HCC). However, the mechanisms that regulate lipid homeostasis to avoid lipotoxicity in HCC remain elusive.
Meiling Ren +4 more
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