Results 1 to 10 of about 11,378,483 (362)
Frontiers in Bioscience-Landmark, 2023 Background: Pyroptosis plays a crucial role in anti-tumor immunity and in formation of the immune microenvironment. However, whether pyroptosis is involved in the progression of clear cell renal cell carcinoma (ccRCC) is still unclear.
Jinpeng Ma +12 more
doaj +1 more source
Frontiers in Oncology, 2022 Radiotherapy is one of the most effective and frequently used treatments for a wide range of cancers. In addition to its direct anti-cancer cytotoxic effects, ionising radiation can augment the anti-tumour immune response by triggering pro-inflammatory ...
Charleen M. L. Chan Wah Hak +5 more
doaj +1 more source
Advancements in clinical aspects of targeted therapy and immunotherapy in breast cancer
Molecular Cancer, 2023 Breast cancer is the second leading cause of death for women worldwide. The heterogeneity of this disease presents a big challenge in its therapeutic management.
Feng Ye +9 more
semanticscholar +1 more source
Targeted cancer therapies [PDF]
Chinese Journal of Cancer, 2011 With unprecedented understanding of molecular events underlying human cancer in this genomic era, a large number of drugs specifically targeting hypothesized oncogenic drivers to which tumors are potentially addicted to have been developed and continue to be developed.
Yan, Li, Rosen, Neal, Arteaga, Carlos
openaire +2 more sources
Recent advances in non-small cell lung cancer targeted therapy; an update review
Cancer Cell International, 2023 Lung cancer continues to be the leading cause of cancer-related death worldwide. In the last decade, significant advancements in the diagnosis and treatment of lung cancer, particularly NSCLC, have been achieved with the help of molecular translational ...
M. Araghi +10 more
semanticscholar +1 more source
Liposomes for Tumor Targeted Therapy: A Review
International Journal of Molecular Sciences, 2023 Liposomes, the most widely studied nano-drug carriers in drug delivery, are sphere-shaped vesicles consisting of one or more phospholipid bilayers. Compared with traditional drug delivery systems, liposomes exhibit prominent properties that include ...
Shile Wang +3 more
semanticscholar +1 more source
Targeted therapy for head and neck cancer: signaling pathways and clinical studies
Signal Transduction and Targeted Therapy, 2023 Head and neck cancer (HNC) is malignant, genetically complex and difficult to treat and is the sixth most frequent cancer, with tobacco, alcohol and human papillomavirus being major risk factors. Based on epigenetic data, HNC is remarkably heterogeneous,
Qingfang Li +4 more
semanticscholar +1 more source
Ursodeoxycholic acid suppresses the malignant progression of colorectal cancer through TGR5-YAP axis
Cell Death Discovery, 2021 The Hippo/YAP pathway plays an important role in the development of cancers. Previous studies have reported that bile acids can activate YAP (Yes Associated Protein) to promote tumorigenesis and tumor progression.
Huan Zhang +4 more
doaj +1 more source
Signaling pathways in rheumatoid arthritis: implications for targeted therapy
Signal Transduction and Targeted Therapy, 2023 Rheumatoid arthritis (RA) is an incurable systemic autoimmune disease. Disease progression leads to joint deformity and associated loss of function, which significantly impacts the quality of life for sufferers and adds to losses in the labor force.
Qian Ding +9 more
semanticscholar +1 more source
Cholesterol activates the Wnt/PCP-YAP signaling in SOAT1-targeted treatment of colon cancer
Cell Death Discovery, 2021 Intracellular free cholesterol can be converted to cholesteryl ester and stored as lipid droplets through SOAT1-mediated esterification. Compelling evidence implicate targeting SOAT1 as a promising therapeutic strategy for cancer management.
Huanji Xu +4 more
doaj +1 more source