Results 11 to 20 of about 1,011,686 (269)

An epithelial-mesenchymal transition-related 5-gene signature predicting the prognosis of hepatocellular carcinoma patients

Cancer Cell International, 2021
Background Tumor metastasis is one of the leading reasons of the dismal prognosis of hepatocellular carcinoma (HCC). Epithelial-mesenchymal transition (EMT) is closely associated with tumor metastasis including HCC.
Gongmin Zhu, Hongwei Xia, Qiulin Tang, Feng Bi   +3 more
doaj   +1 more source

Survival Prediction in Gallbladder Cancer Using CT Based Machine Learning

Frontiers in Oncology, 2020
ObjectiveTo establish a classifier for accurately predicting the overall survival of gallbladder cancer (GBC) patients by analyzing pre-treatment CT images using machine learning technology.MethodsThis retrospective study included 141 patients with ...
Zefan Liu, Guannan Zhu, Xian Jiang, Yunuo Zhao, Hao Zeng, Jing Jing, Xuelei Ma, Xuelei Ma   +7 more
doaj   +1 more source

Development of a human immuno-oncology therapeutic agent targeting HER2: targeted delivery of granzyme B

Journal of Experimental & Clinical Cancer Research, 2019
Background Immunotherapeutic approaches designed to augment T and B cell mediated killing of tumor cells has met with clinical success in recent years suggesting tremendous potential for treatment in a broad spectrum of tumor types.
Lawrence H. Cheung, Yunli Zhao, Ana Alvarez-Cienfuegos, Khalid A. Mohamedali, Yu J. Cao, Walter N. Hittelman, Michael G. Rosenblum   +6 more
doaj   +1 more source

Reprogramming the immunosuppressive tumor microenvironment results in successful clearance of tumors resistant to radiation therapy and anti-PD-1/PD-L1

OncoImmunology, 2023
Despite breakthroughs in immune checkpoint inhibitors (ICI), the majority of tumors, including those poorly infiltrated by CD8+ T cells or heavily infiltrated by immunosuppressive immune effector cells, are unlikely to result in clinically meaningful ...
Debayan Mukherjee, Erminia Romano, Richard Walshaw, Leo A. H. Zeef, Antonia Banyard, Stephen J. Kitcatt, Eleanor J. Cheadle, Karoliina Tuomela, Swati Pendharkar, Aws Al-Deka, Beatrice Salerno, Sophie Raby, Ian G. Mills, Jamie Honeychurch, Tim M. Illidge   +14 more
doaj   +1 more source

Oncolytic Reovirus-Mediated Recruitment of Early Innate Immune Responses Reverses Immunotherapy Resistance in Prostate Tumors

Molecular Therapy: Oncolytics, 2021
Prostate cancers are considered “cold” tumors characterized by minimal T cell infiltrates, absence of a type I interferon (IFN) signature, and the presence of immunosuppressive cells.
Nicola E. Annels, Guy R. Simpson, Mick Denyer, Mehreen Arif, Matt Coffey, Alan Melcher, Kevin Harrington, Richard Vile, Hardev Pandha   +8 more
doaj   +1 more source

Role of oncogenic KRAS in the prognosis, diagnosis and treatment of colorectal cancer

Molecular Cancer, 2021
Colorectal cancer (CRC) is a heterogeneous disease at the cellular and molecular levels. Kirsten rat sarcoma (KRAS) is a commonly mutated oncogene in CRC, with mutations in approximately 40% of all CRC cases; its mutations result in constitutive ...
Gongmin Zhu, Lijiao Pei, Hongwei Xia, Qiulin Tang, Feng Bi   +4 more
doaj   +1 more source

What role does pyroptosis play in cancer?

Molecular Metabolism, 2022
Background: Pyroptosis has been attracting much attention recently. We have briefly compared its differences and similarities with other programmed deaths and the process of its study. With further exploration of the caspase family, including caspase-1/3/
Chen Huang, Jian Li, Chenliang Zhang
doaj   +1 more source

Targeting the key cholesterol biosynthesis enzyme squalene monooxygenasefor cancer therapy

Frontiers in Oncology, 2022
Cholesterol metabolism is often dysregulated in cancer. Squalene monooxygenase (SQLE) is the second rate-limiting enzyme involved in cholesterol synthesis.
Yuheng Zou, Hongying Zhang, Feng Bi, Qiulin Tang, Huanji Xu   +4 more
doaj   +1 more source

Characterization and Mechanistic Studies of a Novel Melanoma-Targeting Construct Containing IκBa for Specific Inhibition of Nuclear Factor-κB Activity

Neoplasia: An International Journal for Oncology Research, 2010
The transcription factor nuclear factor-κB (NF-κB) is a central mediator of growth and homeostasis for both normal and neoplastic cells. IκBα is the natural intracellular inhibitor of NF-κB and can effectively complex with and thereby inhibit the ...
Hong Zhou, Yuying Liu, Lawrence H. Cheung, Sehoon Kim, Weihe Zhang, Khalid A. Mohamedali, Preetha Anand, Walter N. Hittelman, Bharat B. Aggarwal, Michael G. Rosenblum   +9 more
doaj   +1 more source

Long Non-coding RNA BTG3-7:1 and JUND Co-regulate C21ORF91 to Promote Triple-Negative Breast Cancer Progress

Frontiers in Molecular Biosciences, 2021
BackgroundTriple-negative breast cancer (TNBC) is a type of highly invasive breast cancer with poor prognosis. Recently, massive data reveal that long non-coding RNAs (lncRNAs) play important roles in cancer progress.
Zheng Dan, He Xiujing, Luo Ting, Zhong Xiaorong, Zheng Hong, Yang Jiqiao, Li Yanchu, Jing Jing   +7 more
doaj   +1 more source