Results 11 to 20 of about 10,998,800 (355)
Geburtshilfe und Frauenheilkunde, 2015 Bisphosphonates and denosumab are well established components of the therapy for osteoporosis and osseous metastases. Their relevance in the adjuvant situation for breast cancer patients is being discussed in part controversially due to the heterogeneous nature of the available data.
J, Salmen, M, Banys-Paluchowski, T, Fehm
openaire +2 more sources
Molecular targeted therapy for anticancer treatment
Experimental and Molecular Medicine, 2022 Since the initial clinical approval in the late 1990s and remarkable anticancer effects for certain types of cancer, molecular targeted therapy utilizing small molecule agents or therapeutic monoclonal antibodies acting as signal transduction inhibitors ...
H. Min, Ho Young Lee
semanticscholar +1 more source
Cholesterol activates the Wnt/PCP-YAP signaling in SOAT1-targeted treatment of colon cancer
Cell Death Discovery, 2021 Intracellular free cholesterol can be converted to cholesteryl ester and stored as lipid droplets through SOAT1-mediated esterification. Compelling evidence implicate targeting SOAT1 as a promising therapeutic strategy for cancer management.
Huanji Xu +4 more
doaj +1 more source
Comprehensive review of targeted therapy for colorectal cancer
Signal Transduction and Targeted Therapy, 2020 Colorectal cancer (CRC) is among the most lethal and prevalent malignancies in the world and was responsible for nearly 881,000 cancer-related deaths in 2018. Surgery and chemotherapy have long been the first choices for cancer patients.
Yuanhong Xie, Yingxuan Chen, J. Fang
semanticscholar +1 more source
Targeted therapy for head and neck cancer: signaling pathways and clinical studies
Signal Transduction and Targeted Therapy, 2023 Head and neck cancer (HNC) is malignant, genetically complex and difficult to treat and is the sixth most frequent cancer, with tobacco, alcohol and human papillomavirus being major risk factors. Based on epigenetic data, HNC is remarkably heterogeneous,
Qingfang Li +4 more
semanticscholar +1 more source
Targeting SERT promotes tryptophan metabolism: mechanisms and implications in colon cancer treatment
Journal of Experimental & Clinical Cancer Research, 2021 Background Serotonin signaling has been associated with tumorigenesis and tumor progression. Targeting the serotonin transporter to block serotonin cellular uptake confers antineoplastic effects in various tumors, including colon cancer.
Di Ye +5 more
doaj +1 more source
Tumor cell plasticity in targeted therapy-induced resistance: mechanisms and new strategies
Signal Transduction and Targeted Therapy, 2023 Despite the success of targeted therapies in cancer treatment, therapy-induced resistance remains a major obstacle to a complete cure. Tumor cells evade treatments and relapse via phenotypic switching driven by intrinsic or induced cell plasticity ...
Zhenjun Shi +8 more
semanticscholar +1 more source
Signal Transduction and Targeted Therapy, 2023 Targeted anticancer drugs block cancer cell growth by interfering with specific signaling pathways vital to carcinogenesis and tumor growth rather than harming all rapidly dividing cells as in cytotoxic chemotherapy.
Jing-Wen Bai, Si-qi Qiu, Guo‐Jun Zhang
semanticscholar +1 more source
Neoadjuvant Chemotherapy, Endocrine Therapy, and Targeted Therapy for Breast Cancer: ASCO Guideline
Journal of Clinical Oncology, 2021 PURPOSE To develop guideline recommendations concerning optimal neoadjuvant therapy for breast cancer. METHODS ASCO convened an Expert Panel to conduct a systematic review of the literature on neoadjuvant therapy for breast cancer and provide recommended
L. Korde +16 more
semanticscholar +1 more source
Review of precision cancer medicine: Evolution of the treatment paradigm. [PDF]
, 2020 In recent years, biotechnological breakthroughs have led to identification of complex and unique biologic features associated with carcinogenesis. Tumor and cell-free DNA profiling, immune markers, and proteomic and RNA analyses are used to identify ...
Fountzilas, Elena +3 more
core +1 more source