Results 31 to 40 of about 10,998,800 (355)

Signaling pathways and targeted therapy for myocardial infarction

Signal Transduction and Targeted Therapy, 2022
Although the treatment of myocardial infarction (MI) has improved considerably, it is still a worldwide disease with high morbidity and high mortality.
Qing Zhang, Lu Wang, Shiqi Wang, Hongxin Cheng, Lin Xu, G. Pei, Yang Wang, Chenying Fu, Yangfu Jiang, Chengqi He, Q. Wei   +10 more
semanticscholar   +1 more source

Stromal cell inhibition of anti-CD20 antibody mediated killing of B-cell malignancies

Frontiers in Cell and Developmental Biology, 2023
Introduction: The glycoengineered type II anti-CD20 monoclonal antibody obinutuzumab has been licensed for treatment in follicular non-Hodgkin lymphoma and B-CLL following clinical trials demonstrating superior outcomes to standard of care treatment ...
Ester Fagnano, Swati Pendharkar, Madyson Colton, Philip N. Jones, Marta Crespi Sallan, Tetyana Klymenko, Andrejs Braun, Christian Klein, Jamie Honeychurch, Eleanor J. Cheadle, Timothy M. Illidge   +10 more
doaj   +1 more source

Immune Checkpoint Inhibitors Combined with Targeted Therapy: The Recent Advances and Future Potentials

Cancers, 2023
Simple Summary Immune checkpoint inhibitors (ICIs) are the most mature treatment of immunotherapy and have changed the mode of cancer treatment. Recent studies showed that combining ICIs with targeted drugs is a potential strategy in some tumors, while ...
Bin Li, Juan Jin, Duancheng Guo, Z. Tao, Xichun Hu   +4 more
semanticscholar   +1 more source

Autophagic sequestration of SQSTM1 disrupts the aggresome formation of ubiquitinated proteins during proteasome inhibition

Cell Death and Disease, 2022
Aggresome formation is a protective cellular response to counteract proteasome dysfunction by sequestering misfolded proteins and reducing proteotoxic stress.
Chenliang Zhang, Chen Huang, Hongwei Xia, Huanji Xu, Qiulin Tang, Feng Bi   +5 more
doaj   +1 more source

An epithelial-mesenchymal transition-related 5-gene signature predicting the prognosis of hepatocellular carcinoma patients

Cancer Cell International, 2021
Background Tumor metastasis is one of the leading reasons of the dismal prognosis of hepatocellular carcinoma (HCC). Epithelial-mesenchymal transition (EMT) is closely associated with tumor metastasis including HCC.
Gongmin Zhu, Hongwei Xia, Qiulin Tang, Feng Bi   +3 more
doaj   +1 more source

Targeting Oncogenic BRAF: Past, Present, and Future. [PDF]

, 2019
Identifying recurrent somatic genetic alterations of, and dependency on, the kinase BRAF has enabled a "precision medicine" paradigm to diagnose and treat BRAF-driven tumors.
Bivona, Trever G, Wu, Wei, Zaman, Aubhishek   +2 more
core   +1 more source

Survival Prediction in Gallbladder Cancer Using CT Based Machine Learning

Frontiers in Oncology, 2020
ObjectiveTo establish a classifier for accurately predicting the overall survival of gallbladder cancer (GBC) patients by analyzing pre-treatment CT images using machine learning technology.MethodsThis retrospective study included 141 patients with ...
Zefan Liu, Guannan Zhu, Xian Jiang, Yunuo Zhao, Hao Zeng, Jing Jing, Xuelei Ma, Xuelei Ma   +7 more
doaj   +1 more source

The natural dietary genistein boosts bacteriophage-mediated cancer cell killing by improving phage-targeted tumor cell transduction [PDF]

, 2016
Gene therapy has long been regarded as a promising treatment for cancer. However, cancer gene therapy is still facing the challenge of targeting gene delivery vectors specifically to tumors when administered via clinically acceptable non-invasive ...
Albahrani, M, Bentayebi, K, Hajitou, A, Przystal, J, Suwan, K, Tsafa, E   +5 more
core   +2 more sources

Targeted Perfusion Therapy in Spinal Cord Trauma. [PDF]

, 2020
We review state-of-the-art monitoring techniques for acute, severe traumatic spinal cord injury (TSCI) to facilitate targeted perfusion of the injured cord rather than applying universal mean arterial pressure targets.
Papadopoulos, MC, Saadoun, S
core   +1 more source

Bromodomain and extraterminal (BET) proteins: biological functions, diseases and targeted therapy

Signal Transduction and Targeted Therapy, 2023
BET proteins, which influence gene expression and contribute to the development of cancer, are epigenetic interpreters. Thus, BET inhibitors represent a novel form of epigenetic anticancer treatment.
Zhi-Qiang Wang, Zhaocong Zhang, Yu-Yang Wu, Yanan Pi, Sheng-Han Lou, T. Liu, Ge Lou, Chang Yang   +7 more
semanticscholar   +1 more source