Results 41 to 50 of about 10,998,800 (355)

Development of a human immuno-oncology therapeutic agent targeting HER2: targeted delivery of granzyme B

Journal of Experimental & Clinical Cancer Research, 2019
Background Immunotherapeutic approaches designed to augment T and B cell mediated killing of tumor cells has met with clinical success in recent years suggesting tremendous potential for treatment in a broad spectrum of tumor types.
Lawrence H. Cheung, Yunli Zhao, Ana Alvarez-Cienfuegos, Khalid A. Mohamedali, Yu J. Cao, Walter N. Hittelman, Michael G. Rosenblum   +6 more
doaj   +1 more source

TOP2A and EZH2 Provide Early Detection of an Aggressive Prostate Cancer Subgroup. [PDF]

, 2017
Purpose: Current clinical parameters do not stratify indolent from aggressive prostate cancer. Aggressive prostate cancer, defined by the progression from localized disease to metastasis, is responsible for the majority of prostate cancer–associated ...
Alshalalfa, Mohammed,, Bowden, Michaela,, Brown, Myles,, Davicioni, Elai,, Den, Robert B.,, Ellis, Leigh,, Eng, Kevin H.,, Erho, Nicholas,, Feng, Felix Y.,, Galbo, Phillip,, Goodrich, David W.,, Gray, Kathryn P.,, Huang, Ying,, Jenkins, Robert B.,, Karnes, R. Jeffrey,, Ku, Sheng Yu,, Labbé, David P.,, Lund University., Rosario, Spencer,, Ross, Ashley E., Schaeffer, Edward M.,, Sjöström, Martin,, Spratt, Daniel E.,, Sweeney, Christopher J.,, Wadosky, Kristine M.,   +24 more
core   +2 more sources

Next-Generation Sequencing: Targeting Targeted Therapies [PDF]

Clinical Cancer Research, 2015
Abstract Next-generation sequencing (NGS) has given new perspective in oncology. With the ongoing development of targeted therapies, NGS is evolving molecular diagnostics by providing comprehensive interrogation of clinically actionable genomic aberrations in tumors.
Justine N, McCutcheon, Giuseppe, Giaccone   +1 more
openaire   +2 more sources

Non-Small Cell Lung Cancer Targeted Therapy: Drugs and Mechanisms of Drug Resistance

International Journal of Molecular Sciences, 2022
The advent of precision medicine has brought light to the treatment of non-small cell lung cancer (NSCLC), expanding the options for patients with advanced NSCLC by targeting therapy through genetic and epigenetic cues.
Jiajia Wu, Zhenghong Lin
semanticscholar   +1 more source

Targeted therapy for breast cancer prevention. [PDF]

, 2013
With a better understanding of the etiology of breast cancer, molecularly targeted drugs have been developed and are being testing for the treatment and prevention of breast cancer.
Brown, Powel H, den Hollander, Petra, Savage, Michelle I   +2 more
core   +2 more sources

Ectopic JAK–STAT activation enables the transition to a stem-like and multilineage state conferring AR-targeted therapy resistance

Nature Cancer, 2022
Emerging evidence indicates that various cancers can gain resistance to targeted therapies by acquiring lineage plasticity. Although various genomic and transcriptomic aberrations correlate with lineage plasticity, the molecular mechanisms enabling the ...
S. Deng, Choushi Wang, Yunguan Wang, Yaru Xu, Xiaoling Li, N. A. Johnson, Atreyi Mukherji, U. Lo, Lingfan Xu, Julisa Gonzalez, Lauren A Metang, Jianfeng Ye, Carla Rodriguez Tirado, Kathia E Rodarte, Yinglu Zhou, Zhiqun Xie, C. Arana, Valli Annamalai, Xihui Liu, Donald J. Vander Griend, Douglas W. Strand, J. Hsieh, Bo Li, Ganesh V Raj, Tao Wang, P. Mu   +25 more
semanticscholar   +1 more source

Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer

Signal Transduction and Targeted Therapy, 2021
To flourish, cancers greatly depend on their surrounding tumor microenvironment (TME), and cancer-associated fibroblasts (CAFs) in TME are critical for cancer occurrence and progression because of their versatile roles in extracellular matrix remodeling,
Fanglong Wu, Jin Yang, Junjiang Liu, Ye Wang, J. Mu, Qingxiang Zeng, Shuzhi Deng, Hongmei Zhou   +7 more
semanticscholar   +1 more source

Melanocortin 1 receptor targeted imaging of melanoma with gold nanocages and positron emission tomography [PDF]

, 2018
Purpose: Melanoma is a lethal skin cancer with unmet clinical needs for targeted imaging and therapy. Nanoscale materials conjugated with targeting components have shown great potential to improve tumor delivery efficiency while minimizing undesirable ...
Black, Kvar, Detering, Lisa, Liu, Yongjian, Luehmann, Hannah, Pang, Bo, Sultan, Deborah, Xia, Younan, Yang, Miaoxin, Zhao, Yongfeng   +8 more
core   +2 more sources

Targeted therapy in advanced non-small cell lung cancer: current advances and future trends

Journal of Hematology & Oncology, 2021
Lung cancer remains the leading cause of cancer-related mortality in both men and women in the US and worldwide. Non-small cell lung cancer is the most common variety accounting for 84% of the cases.
U. Majeed, R. Manochakian, Yujie Zhao, Y. Lou   +3 more
semanticscholar   +1 more source

Therapy of pancreatic cancer via an EphA2 receptor-targeted delivery of gemcitabine. [PDF]

, 2016
First line treatment for pancreatic cancer consists of surgical resection, if possible, and a subsequent course of chemotherapy using the nucleoside analogue gemcitabine.
Barile, Elisa, Das, Swadesh K, De, Surya K, Emdad, Luni, Fisher, Paul B, Morvaridi, Susan Kharagh, Pandol, Stephen J, Pellecchia, Maurizio, Quinn, Bridget A, Sarkar, Devanand, Stebbins, John L, Wang, Si   +11 more
core   +7 more sources