Results 91 to 100 of about 23,906,714 (250)
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Final report of the Task Force on Nonprofit, Faith-based, and Other Nonprofit Organizations
, 2002 Title from PDF caption (viewed Dec.
Task Force on Nonprofit, Faith-based, and Other Nonprofit Organizations. +1 more
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Implementing Task Based Approach in ESP Education: Business schools as a Case Study
AcuityIt is asserted that task-based instruction improves the environment and makes it easier to teach English. Due to this, many EF language teachers and syllabus developers have recently turned their attention to task-based language education.
Fatima Zahra EL ARBAOUI
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Report of the CLA Task Force on Foreign Language Instruction, June, 1983
, 1983 University of Minnesota. College of Liberal Arts. Task Force on Foreign Language Instruction, 1983. (1983). Report of the CLA Task Force on Foreign Language Instruction, June, 1983.
University of Minnesota. College of Liberal Arts. Task Force on Foreign Language Instruction, 1983
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Instructing somebody else to act: motor co-representations in the instructor
Royal Society Open ScienceInstructions enable humans to perform novel tasks quickly. This is achieved by creating and activating the instruction representation for upcoming tasks, which can then modulate ongoing task behaviour in an almost ‘reflexive’ manner, an effect called ...
Mathias Van der Biest +4 more
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
, 2015 This archived document is maintained by the Oregon State Library as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Title from PDF cover (viewed on January 25, 2016)."...
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Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source