Results 71 to 80 of about 188,887 (312)

Internet-based instruction in college teaching [PDF]

, 1999
Distance education and Internet instruction are increasingly being used in college science teaching. In an effort to reach more students, Iowa State University's Human Anatomy and Physiology course was offered via Internet as well as via traditional ...
Flickinger, Kathleen
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

When Does Instruction Tuning Work in Biomedical NLP? A Structural, Task-Aware, and Safety–Critical Evaluation of Large Language Models

IEEE Access
Instruction tuning has emerged as an effective mechanism for adapting large language models (LLMs) to biomedical natural language processing (BioNLP), enabling improved task generalization with reduced reliance on extensive domain-specific pretraining ...
Aytug Onan, Arbi Haza Nasution, Tugba Celikten   +2 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

如何以任務導向與讀者反應教學法在ESL 課程教授兒童文學 [PDF]

, 2013
[[abstract]]This study uses task-based and reader response approaches to examine how the instruction works to booster students’ motivation when teaching children’s literature in an ESL classroom.
Chung, Shu-Mei; Lee, Mei-Yan
core  

The Effects of Schema-Based Instruction on Word-Problems in a ThirdGrade Mathematics Classroom [PDF]

, 2023
In this study we tested the effects of schema-based instruction (SBI) strategies on 3 rd grade students’ mathematics skills. We compared SBI to general strategy instruction (GSI) when teaching multi-step word problems to students in mixedabilities ...
Skinner, Mallory G., Cuevas , Joshua A.
core  

Improving the Quality of Translation Education in Iraq

Cihan University-Erbil Journal of Humanities and Social Sciences
Translation is considered a main field of language and human sciences today. The Iraqi Ministry of Higher Education and Scientific Research has paid special attention to translation since the 20th century and this attention has expanded since 2003.
Imadin M. Zannrni, Raad S. Rauf, Laila B. Shareef   +2 more
doaj   +1 more source

The Effect of Data-driven Learning & Image-schema-based Polysemy Networks Instruction on Learning Spatial Prepositions of Verticality: The Case of Moroccan EFL Learners

Arbitrer, 2020
This paper reports on a quasi-experimental study investigating the effects of a teaching methodology that combines Cognitive Linguistics (CL) and Corpus Linguistics (CrpL) insights on the acquisition of the two sets of English spatial prepositions of ...
Nihal Bouabida
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source