Results 1 to 10 of about 6,739,561 (230)

Serum Tau Proteins as Potential Biomarkers for the Assessment of Alzheimer's Disease Progression. [PDF]

Int J Mol Sci, 2020
Total tau (t-tau) and phosphorylated tau (p-tau) protein elevations in cerebrospinal fluid (CFS) are well-established hallmarks of Alzheimer’s disease (AD), while the associations of serum t-tau and p-tau levels with AD have been inconsistent across ...
Nam E, Lee YB, Moon C, Chang KA.
europepmc   +2 more sources

Spread of pathological tau proteins through communicating neurons in human Alzheimer's disease. [PDF]

Nat Commun, 2020
Tau is a hallmark pathology of Alzheimer’s disease, and animal models have suggested that tau spreads from cell to cell through neuronal connections, facilitated by β-amyloid (Aβ). We test this hypothesis in humans using an epidemic spreading model (ESM)
Vogel JW, Iturria-Medina Y, Strandberg OT, Smith R, Levitis E, Evans AC, Hansson O, Alzheimer’s Disease Neuroimaging Initiative, Swedish BioFinder Study.   +8 more
europepmc   +2 more sources

Role of Amyloid-β and Tau Proteins in Alzheimer's Disease: Confuting the Amyloid Cascade. [PDF]

J Alzheimers Dis, 2018
The “Amyloid Cascade Hypothesis” has dominated the Alzheimer’s disease (AD) field in the last 25 years. It posits that the increase of amyloid-β (Aβ) is the key event in AD that triggers tau pathology followed by neuronal death and eventually, the ...
Gulisano W, Maugeri D, Baltrons MA, Fà M, Amato A, Palmeri A, D'Adamio L, Grassi C, Devanand DP, Honig LS, Puzzo D, Arancio O.   +11 more
europepmc   +2 more sources

Deletion of endogenous Tau proteins is not detrimental in Drosophila. [PDF]

Sci Rep, 2016
Human Tau (hTau) is a highly soluble and natively unfolded protein that binds to microtubules within neurons. Its dysfunction and aggregation into insoluble paired helical filaments is involved in the pathogenesis of Alzheimer’s disease (AD ...
Burnouf S, Grönke S, Augustin H, Dols J, Gorsky MK, Werner J, Kerr F, Alic N, Martinez P, Partridge L.   +9 more
europepmc   +2 more sources

Immunochemical and biochemical characterization of tau proteins in normal and Alzheimer's disease brains with Alz 50 and Tau-1.

Journal of Biological Chemistry, 1988
Microtubule-associated protein tau was characterized in 5 Alzheimer and 5 control brains using two monoclonal antibodies, Alz 50 and Tau-1. Quantitative analysis of immunoblots with the antibodies showed that both homogenate and supernatant fractions (12,
Hanna Ksiȩżak-Reding, Lester I. Binder, S. -H. Yen   +2 more
openalex   +2 more sources

Tau Proteins and Tauopathies in Alzheimer's Disease. [PDF]

Cell Mol Neurobiol, 2018
Chong FP, Ng KY, Koh RY, Chye SM.
europepmc   +2 more sources

The role of A β and Tau proteins in Alzheimer's disease: a mathematical model on graphs. [PDF]

J Math Biol, 2023
Bertsch M, Franchi B, Tesi MC, Tora V.
europepmc   +2 more sources

Discriminating between native and phosphorylated tau proteins using fluid‐lipid bilayer‐coated nanopores [PDF]

Alzheimers Dement
Awasthi S, Mayer M.
europepmc   +3 more sources

Autophagy and Tau Protein [PDF]

International Journal of Molecular Sciences, 2021
Neurofibrillary tangles, which consist of highly phosphorylated tau protein, and senile plaques (SPs) are pathological hallmarks of Alzheimer’s disease (AD). In swollen axons, many autophagic vacuoles are observed around SP in the AD brain. This suggests that autophagy function is disturbed in AD.
Tadanori Hamano, Soichi Enomoto, Norimichi Shirafuji, Masamichi Ikawa, Osamu Yamamura, Shu-Hui Yen, Yasunari Nakamoto   +6 more
openaire   +2 more sources

Nuclear tau and its potential role in Alzheimer’s disease [PDF]

, 2016
Tau protein, found in both neuronal and non-neuronal cells, forms aggregates in neurons that constitutes one of the hallmarks of Alzheimer’s disease (AD).
Al-Hilaly, Youssra, Bukar Maina, Mahmoud, Serpell, Louise   +2 more
core   +6 more sources