Results 11 to 20 of about 5,753,344 (186)

Distribution of tau proteins in the normal human central and peripheral nervous system.

Journal of Histochemistry and Cytochemistry, 1989
John Q. Trojanowski, Theresa Schuck, Maria Luiza Gava Schmidt, V M Lee   +3 more
openalex   +2 more sources

Tau interactome and RNA binding proteins in neurodegenerative diseases

Molecular Neurodegeneration, 2022
Pathological tau aggregation is a primary neuropathological feature of many neurodegenerative diseases. Intriguingly, despite the common presence of tau aggregates in these diseases the affected brain regions, clinical symptoms, and morphology ...
Tomas Kavanagh, Aditi Halder, Eleanor Drummond   +2 more
doaj   +1 more source

Tau mRNA Metabolism in Neurodegenerative Diseases: A Tangle Journey

Biomedicines, 2022
Tau proteins are known to be mainly involved in regulation of microtubule dynamics. Besides this function, which is critical for axonal transport and signal transduction, tau proteins also have other roles in neurons.
Paulo J. da Costa, Malika Hamdane, Luc Buée, Franck Martin   +3 more
doaj   +1 more source

Cerebrospinal fluid tau levels are associated with abnormal neuronal plasticity markers in Alzheimer’s disease

Molecular Neurodegeneration, 2022
Background Increased total tau (t-tau) in cerebrospinal fluid (CSF) is a key characteristic of Alzheimer’s disease (AD) and is considered to result from neurodegeneration.
Pieter Jelle Visser, Lianne M. Reus, Johan Gobom, Iris Jansen, Ellen Dicks, Sven J. van der Lee, Magda Tsolaki, Frans R. J. Verhey, Julius Popp, Pablo Martinez-Lage, Rik Vandenberghe, Alberto Lleó, José Luís Molinuevo, Sebastiaan Engelborghs, Yvonne Freund-Levi, Lutz Froelich, Kristel Sleegers, Valerija Dobricic, Simon Lovestone, Johannes Streffer, Stephanie J. B. Vos, Isabelle Bos, ADNI, August B. Smit, Kaj Blennow, Philip Scheltens, Charlotte E. Teunissen, Lars Bertram, Henrik Zetterberg, Betty M. Tijms   +29 more
doaj   +1 more source

Phosphorylated Tau in Alzheimer’s Disease and Other Tauopathies

International Journal of Molecular Sciences, 2022
Alzheimer’s disease (AD) is the leading cause of dementia in elderly people. Amyloid beta (Aβ) deposits and neurofibrillary tangles are the major pathological features in an Alzheimer’s brain.
P. Rawat, Ujala Sehar, Jasbir Bisht, Ashley Selman, J. Culberson, P. Reddy   +5 more
semanticscholar   +1 more source

Amyloid-beta and tau protein beyond Alzheimer’s disease

Neural Regeneration Research, 2023
The aggregation of amyloid-beta peptide and tau protein dysregulation are implicated to play key roles in Alzheimer’s disease pathogenesis and are considered the main pathological hallmarks of this devastating disease. Physiologically, these two proteins
M. Abyadeh, Vivek Gupta, Joao A. Paulo, Arezoo Gohari Mahmoudabad, Sina Shadfar, Shahab Mirshahvaladi, Veer B Gupta, Christine T O Nguyen, David I. Finkelstein, Yuyi You, Paul A Haynes, G. H. Salekdeh, Stuart L. Graham, Mehdi Mirzaei   +13 more
semanticscholar   +1 more source

Alzheimer PHF-tau aggregates do not spread tau pathology to the brain via the Retino-tectal projection after intraocular injection in male mouse models

Neurobiology of Disease, 2022
Neurofibrillary tangles (NFT), a neuronal lesion found in Alzheimer's disease (AD), are composed of fibrillary aggregates of modified forms of tau proteins.
M.-A. de Fisenne, Z. Yilmaz, R. De Decker, V. Suain, L. Buée, K. Ando, J.-P. Brion, K. Leroy   +7 more
doaj   +1 more source

Interaction between Aβ and Tau in the Pathogenesis of Alzheimer's Disease

International Journal on Biological Sciences, 2021
Extracellular neuritic plaques composed of amyloid‑β (Aβ) protein and intracellular neurofibrillary tangles containing phosphorylated tau protein are the two hallmark proteins of Alzheimer's disease (AD), and the separate neurotoxicity of these proteins ...
Huiqin Zhang, Wei Wei, Ming Zhao, Lina Ma, Xuefan Jiang, Hui Pei, Yu Cao, Hao Li   +7 more
semanticscholar   +1 more source

Predicting AT(N) pathologies in Alzheimer’s disease from blood-based proteomic data using neural networks

Frontiers in Aging Neuroscience, 2022
Background and objectiveBlood-based biomarkers represent a promising approach to help identify early Alzheimer’s disease (AD). Previous research has applied traditional machine learning (ML) to analyze plasma omics data and search for potential ...
Yuting Zhang, Upamanyu Ghose, Noel J. Buckley, Sebastiaan Engelborghs, Sebastiaan Engelborghs, Sebastiaan Engelborghs, Kristel Sleegers, Kristel Sleegers, Giovanni B. Frisoni, Anders Wallin, Alberto Lleó, Julius Popp, Julius Popp, Pablo Martinez-Lage, Cristina Legido-Quigley, Cristina Legido-Quigley, Frederik Barkhof, Frederik Barkhof, Henrik Zetterberg, Henrik Zetterberg, Henrik Zetterberg, Henrik Zetterberg, Henrik Zetterberg, Pieter Jelle Visser, Pieter Jelle Visser, Lars Bertram, Lars Bertram, Simon Lovestone, Simon Lovestone, Alejo J. Nevado-Holgado, Liu Shi   +30 more
doaj   +1 more source

Expression of Tau Pathology-Related Proteins in Different Brain Regions: A Molecular Basis of Tau Pathogenesis

Frontiers in Aging Neuroscience, 2017
Microtubule-associated protein tau is hyperphosphorylated and aggregated in affected neurons in Alzheimer disease (AD) brains. The tau pathology starts from the entorhinal cortex (EC), spreads to the hippocampus and frontal and temporal cortices, and ...
Wen Hu, Wen Hu, Feng Wu, Yanchong Zhang, Yanchong Zhang, Cheng-Xin Gong, Khalid Iqbal, Fei Liu, Fei Liu   +8 more
doaj   +1 more source