Results 21 to 30 of about 5,909,902 (374)
Tau interactome and RNA binding proteins in neurodegenerative diseases
Molecular Neurodegeneration, 2022 Pathological tau aggregation is a primary neuropathological feature of many neurodegenerative diseases. Intriguingly, despite the common presence of tau aggregates in these diseases the affected brain regions, clinical symptoms, and morphology ...
Tomas Kavanagh +2 more
doaj +1 more source
Tau mRNA Metabolism in Neurodegenerative Diseases: A Tangle Journey
Biomedicines, 2022 Tau proteins are known to be mainly involved in regulation of microtubule dynamics. Besides this function, which is critical for axonal transport and signal transduction, tau proteins also have other roles in neurons.
Paulo J. da Costa +3 more
doaj +1 more source
Nuclear tau and its potential role in Alzheimer’s disease [PDF]
, 2016 Tau protein, found in both neuronal and non-neuronal cells, forms aggregates in neurons that constitutes one of the hallmarks of Alzheimer’s disease (AD).
Al-Hilaly, Youssra +2 more
core +6 more sources
Molecular Neurodegeneration, 2022 Background Increased total tau (t-tau) in cerebrospinal fluid (CSF) is a key characteristic of Alzheimer’s disease (AD) and is considered to result from neurodegeneration.
Pieter Jelle Visser +29 more
doaj +1 more source
Phosphorylated Tau in Alzheimer’s Disease and Other Tauopathies
International Journal of Molecular Sciences, 2022 Alzheimer’s disease (AD) is the leading cause of dementia in elderly people. Amyloid beta (Aβ) deposits and neurofibrillary tangles are the major pathological features in an Alzheimer’s brain.
P. Rawat +5 more
semanticscholar +1 more source
Interaction between Aβ and Tau in the Pathogenesis of Alzheimer's Disease
International Journal on Biological Sciences, 2021 Extracellular neuritic plaques composed of amyloid‑β (Aβ) protein and intracellular neurofibrillary tangles containing phosphorylated tau protein are the two hallmark proteins of Alzheimer's disease (AD), and the separate neurotoxicity of these proteins ...
Huiqin Zhang +7 more
semanticscholar +1 more source
TTBK2: A Tau Protein Kinase beyond Tau Phosphorylation [PDF]
BioMed Research International, 2015 Tau tubulin kinase 2 (TTBK2) is a kinase known to phosphorylate tau and tubulin. It has recently drawn much attention due to its involvement in multiple important cellular processes. Here, we review the current understanding of TTBK2, including its sequence, structure, binding sites, phosphorylation substrates, and cellular processes involved.
Liao, Jung-Chi +4 more
openaire +3 more sources
Neurobiology of Disease, 2022 Neurofibrillary tangles (NFT), a neuronal lesion found in Alzheimer's disease (AD), are composed of fibrillary aggregates of modified forms of tau proteins.
M.-A. de Fisenne +7 more
doaj +1 more source
Tau: A Signaling Hub Protein [PDF]
Frontiers in Molecular Neuroscience, 2021 Over four decades ago,in vitroexperiments showed that tau protein interacts with and stabilizes microtubules in a phosphorylation-dependent manner. This observation fueled the widespread hypotheses that these properties extend to living neurons and that reduced stability of microtubules represents a major disease-driving event induced by pathological ...
Rebecca L. Mueller +11 more
openaire +4 more sources
Amyloidogenesis of Tau protein [PDF]
Protein Science, 2017 AbstractThe role of microtubule‐associated protein Tau in neurodegeneration has been extensively investigated since the discovery of Tau amyloid aggregates in the brains of patients with Alzheimer's disease (AD). The process of formation of amyloid fibrils is known as amyloidogenesis and attracts much attention as a potential target in the prevention ...
Bartosz Nizynski +2 more
openaire +2 more sources