Results 31 to 40 of about 5,909,902 (374)

Predicting AT(N) pathologies in Alzheimer’s disease from blood-based proteomic data using neural networks

Frontiers in Aging Neuroscience, 2022
Background and objectiveBlood-based biomarkers represent a promising approach to help identify early Alzheimer’s disease (AD). Previous research has applied traditional machine learning (ML) to analyze plasma omics data and search for potential ...
Yuting Zhang, Upamanyu Ghose, Noel J. Buckley, Sebastiaan Engelborghs, Sebastiaan Engelborghs, Sebastiaan Engelborghs, Kristel Sleegers, Kristel Sleegers, Giovanni B. Frisoni, Anders Wallin, Alberto Lleó, Julius Popp, Julius Popp, Pablo Martinez-Lage, Cristina Legido-Quigley, Cristina Legido-Quigley, Frederik Barkhof, Frederik Barkhof, Henrik Zetterberg, Henrik Zetterberg, Henrik Zetterberg, Henrik Zetterberg, Henrik Zetterberg, Pieter Jelle Visser, Pieter Jelle Visser, Lars Bertram, Lars Bertram, Simon Lovestone, Simon Lovestone, Alejo J. Nevado-Holgado, Liu Shi   +30 more
doaj   +1 more source

Amyloid-beta and tau protein beyond Alzheimer’s disease

Neural Regeneration Research, 2023
The aggregation of amyloid-beta peptide and tau protein dysregulation are implicated to play key roles in Alzheimer’s disease pathogenesis and are considered the main pathological hallmarks of this devastating disease. Physiologically, these two proteins
M. Abyadeh, Vivek Gupta, Joao A. Paulo, Arezoo Gohari Mahmoudabad, Sina Shadfar, Shahab Mirshahvaladi, Veer B Gupta, Christine T O Nguyen, David I. Finkelstein, Yuyi You, Paul A Haynes, G. H. Salekdeh, Stuart L. Graham, Mehdi Mirzaei   +13 more
semanticscholar   +1 more source

Expression of Tau Pathology-Related Proteins in Different Brain Regions: A Molecular Basis of Tau Pathogenesis

Frontiers in Aging Neuroscience, 2017
Microtubule-associated protein tau is hyperphosphorylated and aggregated in affected neurons in Alzheimer disease (AD) brains. The tau pathology starts from the entorhinal cortex (EC), spreads to the hippocampus and frontal and temporal cortices, and ...
Wen Hu, Wen Hu, Feng Wu, Yanchong Zhang, Yanchong Zhang, Cheng-Xin Gong, Khalid Iqbal, Fei Liu, Fei Liu   +8 more
doaj   +1 more source

EFhd2 Affects Tau Liquid–Liquid Phase Separation

Frontiers in Neuroscience, 2019
The transition of tau proteins from its soluble physiological conformation to the pathological aggregate forms found in Alzheimer’s disease and related dementias, is poorly understood.
Irving E. Vega, Irving E. Vega, Irving E. Vega, Andrew Umstead, Nicholas M. Kanaan, Nicholas M. Kanaan, Nicholas M. Kanaan   +6 more
doaj   +1 more source

Fibril-forming motifs are essential and sufficient for the fibrillization of human Tau. [PDF]

PLoS ONE, 2012
BACKGROUND: The misfolding of amyloidogenic proteins including human Tau protein, human prion protein, and human α-synuclein is involved in neurodegenerative diseases such as Alzheimer disease, prion disease, and Parkinson disease.
Sheng-Rong Meng, Ying-Zhu Zhu, Tong Guo, Xiao-Ling Liu, Jie Chen, Yi Liang   +5 more
doaj   +1 more source

Controlled cortical impact traumatic brain injury in 3xTg-AD mice causes acute intra-axonal amyloid-β accumulation and independently accelerates the development of tau abnormalities [PDF]

, 2011
Alzheimer\u27s disease (AD) is a neurodegenerative disorder characterized pathologically by progressive neuronal loss, extracellular plaques containing the amyloid-β (Aβ) peptides, and neurofibrillary tangles composed of hyperphosphorylated tau proteins.
Brody, David L, Holtzman, David M, LaFerla, Frank M, Tran, Hien T   +3 more
core   +2 more sources

Blood-based immunoassay of tau proteins for early diagnosis of Alzheimer's disease using surface plasmon resonance fiber sensors

RSC Advances, 2018
We present the immunoassay of tau proteins (total tau and phosphorylated tau) in human sera using surface plasmon resonance (SPR) fiber sensors. This assay aimed at harvesting the advantages of using both SPR fiber sensors and a blood-based assay to ...
Truong Thi Vu Nu, Nhu Hoa Thi Tran, Eunjoo Nam, T. Nguyen, Won Jung Yoon, Sungbo Cho, Jungsuk Kim, Keun-A Chang, H. Ju   +8 more
semanticscholar   +1 more source

Tau binding protein CAPON induces tau aggregation and neurodegeneration [PDF]

Nature Communications, 2019
AbstractTo understand the molecular processes that link Aβ amyloidosis, tauopathy and neurodegeneration, we screened for tau-interacting proteins by immunoprecipitation/LC-MS. We identified the carboxy-terminal PDZ ligand of nNOS (CAPON) as a novel tau-binding protein.
Shoko Hashimoto, Yukio Matsuba, Naoko Kamano, Naomi Mihira, Naruhiko Sahara, Jiro Takano, Shin-ichi Muramatsu, Takaomi C. Saido, Takashi Saito   +8 more
openaire   +3 more sources

The Molecular Chaperone Artemin Efficiently Blocks Fibrillization of TAU Protein In Vitro

Cell Journal, 2017
Objective: Aggregation of the TAU proteins in the form of neurofibrillary tangles (NFTs) in the brain is a common risk factor in tauopathies including Alzheimer’s disease (AD).
Zahra Khosravi, Mohammad Ali Nasiri Khalili, Sharif Moradi, Reza Hassan Sajedi, Mehdi Zeinoddini   +4 more
doaj   +1 more source

Tau drives translational selectivity by interacting with ribosomal proteins

Acta Neuropathologica, 2019
There is a fundamental gap in understanding the consequences of tau–ribosome interactions. Tau oligomers and filaments hinder protein synthesis in vitro, and they associate strongly with ribosomes in vivo.
Shon A. Koren, Matthew Hamm, Shelby Meier, Blaine E. Weiss, Grant K. Nation, Emad A. Chishti, J. P. Arango, J. Chen, Haining Zhu, E. Blalock, J. Abisambra   +10 more
semanticscholar   +1 more source