Results 31 to 40 of about 5,753,344 (185)
Acta Neuropathologica, 2020 Tau and amyloid beta (Aβ) are the prime suspects for driving pathology in Alzheimer’s disease (AD) and, as such, have become the focus of therapeutic development.
Sarah A. Kent +2 more
semanticscholar +1 more source
TIA1 potentiates tau phase separation and promotes generation of toxic oligomeric tau
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Phase separation of proteins is increasingly thought to play a fundamental role in biological processes. Recent studies show that tau protein phase separates, but the biological significance is unknown since artificial crowding agents are ...
Peter E. A. Ash +16 more
semanticscholar +1 more source
The regulatory effect of Tau protein on polymerization of MCF7 microtubules in vitro
Biochemistry and Biophysics Reports, 2019 Growing evidence continues to point toward the critical role of beta tubulin isotypes in regulating some intracellular functions. Changes that were observed in the microtubules’ intrinsic dynamics, the way they interact with some chemotherapeutic agents,
Mitra Shojania Feizabadi +3 more
doaj +1 more source
Frontiers in Neuroscience, 2020 Tauopathies are the most common type of neurodegenerative proteinopathy, being characterized by cytoplasmic aggregates of hyperphosphorylated tau protein. The formation and morphologies of these tau inclusions, the distribution of the lesions and related
Fuyuki Kametani +11 more
doaj +1 more source
Alzheimer disease pathology and the cerebrospinal fluid proteome
Alzheimer’s Research & Therapy, 2018 Background Altered proteome profiles have been reported in both postmortem brain tissues and body fluids of subjects with Alzheimer disease (AD), but their broad relationships with AD pathology, amyloid pathology, and tau-related neurodegeneration have ...
Loïc Dayon +11 more
doaj +1 more source
Differences Between Human and Murine Tau at the N-terminal End
Frontiers in Aging Neuroscience, 2020 Human tauopathies, such as Alzheimer’s disease (AD), have been widely studied in transgenic mice overexpressing human tau in the brain. The longest brain isoforms of Tau in mice and humans show 89% amino acid identity; however, the expression of the ...
Félix Hernández +6 more
doaj +1 more source
Differential effects of an O-GlcNAcase inhibitor on tau phosphorylation. [PDF]
PLoS ONE, 2012 Abnormal hyperphosphorylation of microtubule-associated protein tau plays a crucial role in neurodegeneration in Alzheimer's disease (AD). The aggregation of hyperphosphorylated tau into neurofibrillary tangles is also a hallmark brain lesion of AD.
Yang Yu +12 more
doaj +1 more source
Liquid-liquid phase separation induces pathogenic tau conformations in vitro
Nature Communications, 2020 Formation of membrane-less organelles via liquid-liquid phase separation is one way cells meet the biological requirement for spatiotemporal regulation of cellular components and reactions.
N. Kanaan +3 more
semanticscholar +1 more source
An Update on Blood-Based Markers of Alzheimer’s Disease Using the SiMoA Platform
Neurology and Therapy, 2019 The development of blood-based biomarkers of Alzheimer’s disease (AD) pathology as tools for screening the general population, and as the first step in a multistep process to determine which non-demented individuals are at greatest risk of developing AD ...
Danni Li, Michelle M. Mielke
doaj +1 more source
Phosphorylated tau interactome in the human Alzheimer’s disease brain
Brain : a journal of neurology, 2020 Accumulation of phosphorylated tau (pTau) is a key pathological feature of Alzheimer’s disease (AD). pTau accumulation causes synaptic impairment, neuronal dysfunction and formation of neurofibrillary tangles (NFTs).
Eleanor Drummond +8 more
semanticscholar +1 more source