Results 101 to 110 of about 27,856 (310)
18F-AV-1451 positron emission tomography in Alzheimer's disease and progressive supranuclear palsy. [PDF]
, 2016 The ability to assess the distribution and extent of tau pathology in Alzheimer's disease and progressive supranuclear palsy in vivo would help to develop biomarkers for these tauopathies and clinical trials of disease-modifying therapies.
Aigbirhio, Franklin I +17 more
core +1 more source
Heritability in frontotemporal tauopathies
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 2019 AbstractIntroductionExploring the degree of heritability in a large cohort of frontotemporal lobar degeneration with tau‐immunopositive inclusions (FTLD‐tau) and determining if different FTLD‐tau subtypes are associated with stronger heritability will provide important insight into disease pathogenesis.MethodsUsing modified Goldman pedigree ...
Shelley L. Forrest +9 more
openaire +3 more sources
Noninvasive imaging of amyloid‐beta and tau in rodent and nonhuman primate models
VIEW, EarlyView.Imaging of amyloid‐beta plaque and tau accumulation in rodent and nonhuman primate model of Alzheimer's disease. Created in BioRender. Ni R. 2026. https://BioRender.com/a97h5ec Abstract Neurodegenerative diseases are characterized by the aberrant accumulation of protein aggregates.
Ruiqing Ni, Axel Rominger
wiley +1 more source
The Importance of Tau Phosphorylation for Neurodegenerative Diseases [PDF]
, 2013 Fibrillar deposits of highly phosphorylated tau are a key pathological feature of several neurodegenerative tauopathies including Alzheimer’s disease and some frontotemporal dementias.
Christopher C. J. Miller +3 more
core +2 more sources
Brain Pathology, EarlyView.Post mortem MRI was combined with neuropathological assessments at 600 μm intervals throughout the brain. Through this approach, a three dimensional account of an entire human brain with an intermediate Alzheimer's disease neuropathologic change was created.
Anneke Alkemade +13 more
wiley +1 more source
Tau seeding activity in skin biopsy differentiates tauopathies from synucleinopathies
npj Parkinson's DiseaseMost neurodegenerative diseases lack definitive diagnostic tests, and the identification of easily accessible and reliable biomarkers remains a critical unmet need.
Ilaria Linda Dellarole +19 more
doaj +1 more source
The overexpression of RBM3 alleviates TBI‐induced behaviour impairment and AD‐like tauopathy in mice [PDF]
, 2020 Bingjin Liu +8 more
openalex +1 more source
Neurodegenerative Disease Tauopathies
Annual Review of Pathology: Mechanisms of DiseaseTauopathies are a diverse group of progressive and fatal neurodegenerative diseases characterized by aberrant tau inclusions in the central nervous system. Tau protein forms pathologic fibrillar aggregates that are typically closely associated with neuronal cell death, leading to varied clinical phenotypes including dementia, movement disorders, and ...
Creekmore, Benjamin C. +2 more
openaire +2 more sources
Sialylation patterns in cerebral amyloid angiopathy
Brain Pathology, EarlyView.This study is the first to localize and evaluate sialylation modifications in the context of Alzheimer's Disease and Cerebral Amyloid Angiopathy, revealing a unique disease‐specific increase in intravascular sialylation. Abstract Glycosylation is the most common form of post‐translational modification in the brain and becomes significantly altered in ...
Caitlyn Fastenau +8 more
wiley +1 more source