Results 31 to 40 of about 27,856 (310)

Pneumonia initiates a tauopathy [PDF]

The FASEB Journal, 2021
Abstract Pneumonia causes short‐ and long‐term cognitive dysfunction in a high proportion of patients, although the mechanism(s) responsible for this effect are unknown. Here, we tested the hypothesis that pneumonia‐elicited cytotoxic amyloid and tau variants: (1) are present in the circulation during infection; (2) lead to impairment
Ron Balczon, Mike T. Lin, Ji Young Lee, Adeel Abbasi, Phoibe Renema, Sarah B. Voth, Chun Zhou, Anna Koloteva, C. Michael Francis, Neel R. Sodha, Jean‐Francois Pittet, Brant M. Wagener, Jessica Bell, Chung‐Sik Choi, Corey E. Ventetuolo, Troy Stevens   +15 more
openaire   +2 more sources

Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden [PDF]

, 2010
Background It has traditionally been thought that the pathological accumulation of tau in Alzheimer's disease and other tauopathies facilitates neurodegeneration, which in turn leads to cognitive impairment.
A de Calignon, AD Mosnaim, Amelia G Johnson, B Reisberg, B Zhang, CA Dickey, CA Dickey, Chad A Dickey, Clara Kraft, Edwin J Weeber, EM Sigurdsson, Erin E Congdon, F van Bebber, HM Hassan, I Walter-Sack, J Lewis, Jason E Gestwicki, Jeffrey R Jones, John C O'Leary, John Koren, Jose F Abisambra, K Santacruz, Karen E Duff, Laura J Blair, M Necula, M Oz, Melinda Peters, MJ West, ML Smith, MP Mazanetz, Paul Marinec, Qingyou Li, RS Doody, S Deiana, S Taniguchi, TL Spires-Jones, TM Visarius, UK Jinwal, Umesh K Jinwal   +38 more
core   +6 more sources

Toxic Tau Oligomers Modulated by Novel Curcumin Derivatives [PDF]

, 2019
The pathological aggregation and accumulation of tau, a microtubule-associated protein, is a common feature amongst more than 18 different neurodegenerative diseases that are collectively known as tauopathies.
Bucchieri, Fabio, Ellsworth, Anna, Kayed, Rakez, Lo Cascio, Filippa, Pace, Andrea, Palumbo Piccionello, Antonio, Puangmalai, Nicha   +6 more
core   +1 more source

Prefibrillar Tau oligomers alter the nucleic acid protective function of Tau in hippocampal neurons in vivo

Neurobiology of Disease, 2015
The accumulation of DNA and RNA oxidative damage is observed in cortical and hippocampal neurons from Alzheimer's disease (AD) brains at early stages of pathology.
Marie Violet, Alban Chauderlier, Lucie Delattre, Meryem Tardivel, Meliza Sendid Chouala, Audrey Sultan, Elodie Marciniak, Sandrine Humez, Lester Binder, Rakez Kayed, Bruno Lefebvre, Eliette Bonnefoy, Luc Buée, Marie-Christine Galas   +13 more
doaj   +1 more source

Evaluating the efficacy of purchased antisense oligonucleotides to reduce mouse and human tau in vivo

Frontiers in Molecular Neuroscience, 2023
Many preclinical and clinical studies support the use of antisense oligonucleotides (ASOs) as effective therapeutic strategies. However, acquiring ASOs for research purposes may be limited by partnerships with the pharmaceutical companies.
Pranav Vemula, Kathleen M. Schoch, Timothy M. Miller   +2 more
doaj   +1 more source

Rationale for tau aggregation inhibitor therapy in Alzheimer's disease and other tauopathies [PDF]

, 2010
Preprin
Harrington, Charles R, Storey, John M D, Wischik, Claude M, Wischik, Damon J   +3 more
core   +1 more source

Microglial Hemoxygenase-1 Deletion Reduces Inflammation in the Retina of Old Mice with Tauopathy

Antioxidants, 2022
Tauopathies such as Alzheimer’s disease are characterized by the accumulation of neurotoxic aggregates of tau protein. With aging and, especially, in Alzheimer’s patients, the inducible enzyme heme oxygenase 1 (HO-1) progressively increases in microglia,
José A. Fernández-Albarral, Elena Salobrar-García, José A. Matamoros, Cristina Fernández-Mendívil, Eric del Sastre, Lejing Chen, Rosa de Hoz, Inés López-Cuenca, Lidia Sánchez-Puebla, José M. Ramírez, Juan J. Salazar, Manuela G. Lopez, Ana I. Ramírez   +12 more
doaj   +1 more source

Loss of vesicular dopamine release precedes tauopathy in degenerative dopaminergic neurons in a Drosophila model expressing human tau. [PDF]

, 2013
While a number of genome-wide association studies have identified microtubule-associated protein tau as a strong risk factor for Parkinson's disease (PD), little is known about the mechanism through which human tau can predispose an individual to this ...
Chang, Hui-Yun, Chiang, Ann-Shyn, Chuang, Chia-Lung, Krantz, David E, Lu, Yu-Ning, Wu, Chia-Lin, Wu, Ting-Han   +6 more
core   +2 more sources

Mutant Tau knock-in mice display frontotemporal dementia relevant behaviour and histopathology [PDF]

, 2016
Peer ...
Drever, Benjamin D., Koss, David J., Platt, Bettina, Plucinska, Kaja, Riedel, Gernot, Robinson, Lianne, Stoppelkamp, Sandra, Veselcic, Peter   +7 more
core   +3 more sources

Altered sleep and EEG power in the P301S Tau transgenic mouse model [PDF]

, 2017
OBJECTIVE: Sleep disturbances are prevalent in human tauopathies yet despite the importance of sleep, little is known about its relationship with tau pathology.
Holth, Jerrah K, Holtzman, David M, Mahan, Thomas E, Robinson, Grace O, Rocha, Andreia   +4 more
core   +2 more sources