Results 51 to 60 of about 27,856 (310)

Stratification of brain-derived extracellular vesicles of Alzheimer’s disease patients indicates a unique proteomic content and a higher seeding capacity of small extracellular vesicles

Translational Neurodegeneration
Background Alzheimer’s disease (AD) is the most prominent form of dementia worldwide. It is characterized by tau lesions that spread throughout the brain in a spatio-temporal manner.
Marie Oosterlynck, Elodie Leroux, Balasubramaniam Namasivayam, Thomas Bouillet, Raphaelle Caillierez, Anne Loyens, Daniele Mazur, Romain Perbet, Christophe Lefebvre, Soulaimane Aboulouard, Claude-Alain Maurage, Bertrand Accart, Luc Buée, Morvane Colin   +13 more
doaj   +1 more source

Heparan Sulfate as a Therapeutic Target in Tauopathies: Insights From Zebrafish

Frontiers in Cell and Developmental Biology, 2018
Microtubule-associated protein tau (MAPT) hyperphosphorylation and aggregation, are two hallmarks of a family of neurodegenerative disorders collectively referred to as tauopathies.
Seyedeh Maryam Alavi Naini, Nadia Soussi-Yanicostas   +1 more
doaj   +1 more source

MAPping out distribution routes for kinesin couriers [PDF]

, 2013
In the crowded environment of eukaryotic cells, diffusion is an inefficient distribution mechanism for cellular components. Long-distance active transport is required and is performed by molecular motors including kinesins.
*Ackmann, Adams, Akhmanova, Akhmanova, Akiyama, Al-Bassam, Amadoro, Amos, Audebert, Baas, Baas, Bai, Bananis, Barlan, Bechstedt, Bieling, Binder, Black, Bobinnec, Bonnet, Boucher, Bouquet, Boyne, Bulinski, Bulinski, Burbridge, Burgess, Byrd, Cai, Charalambous, Chu, Cierpicki, Congdon, Cook, Corbo, De Vos, des Portes, des Portes, Desai, Deshpande, Deuel, Dijkmans, Dimitrov, DiTella, Dixit, Douglas, Drewes, Drewes, Duan, Dubey, Duff, Dunn, Eastwood, Ebneth, Erck, Faire, Fourniol, Francis, Friocourt, Fu, Fukushima, Fung, Galaburda, Garnham, Gleeson, Gleeson, Goldstein, Guillaud, Gurland, Hagiwara, Hammond, Hanger, Hanlon, Harada, Hardy, Heins, Hepp, Hidaka, Hirokawa, Hirokawa, Hoang, Horesh, Horiguchi, Huang, Hyman, Iijima, Ikegami, Ikegami, Iqbal, Iqbal, Ittner, Jacobson, Janke, Jenkins, Jimenez-Mateos, Ju, Kamal, Kanaan, Kanai, Kappeler, Kar, Kaslow, Kawaguchi, Kayadjanian, Khatoon, Khawaja, Kim, Klebe, Koizumi, Kondo, Konishi, Kosik, Kowall, Kreitzer, Kueh, LaPointe, Larcher, Larkin, Lawrence, Lazarov, Lee, Leger, Lewis, Liao, Lin, Liu, Liu, Liu, Liu, Lopez, Maas, Makrides, Mandelkow, Mandelkow, Mandell, Marcos, Marszalek, Massinen, Massow, Maurer, McVicker, Meng, Metzger, Miki, Miki, Mok, Moores, Moores, Morfini, Muresan, Nadar, Nakata, Nakata, Nakata, Navone, Nguyen, Nishimura, Noda, Noda, Nogales, Nosten-Bertrand, Omori, Pagon, Palazzo, Paturle-Lafanechere, Peck, Perez, Peterman, Pettersen, Pfenninger, Pfister, Polydoro, Reed, Reifert, Reiner, Saito, Santarella, Sapir, Saragoni, Schaar, Seidel, Seitz, Setou, Setou, Sharp, Shirasu, Silverman, Sindelar, Small, Song, Soppina, Sossey-Alaoui, Spiliotis, Spronsen, Stamer, Stokin, Stoothoff, Sung, Takei, Takemura, Tapia, Taylor, Teng, Terwel, Thinakaran, Thorn, Tien, Tilney, Tint, Tischfield, Trinczek, Tsai, Uchida, Utton, Vale, Vale, Verhey, Verhey, Vershinin, Vreugdenhil, Wade, Wagner, Walter, Wordeman, Xu, Yajima, Yamazaki, Yang, Yang, Ye, Yonekawa, Yoshimura, Yu, Yuan, Zempel, Zhang   +235 more
core   +1 more source

Transplantation of GABAergic Interneuron Progenitors Restores Cortical Circuit Function in an Alzheimer's Disease Mouse Model

Advanced Science, EarlyView.
Transplantation of medial ganglionic eminence (MGE) interneuron progenitors into APP/PS1 cortices restored the slow oscillation characteristic of Alzheimer's disease. Donor cells survived, migrated, and matured into functional GABAergic interneurons, forming synaptic connections.
Shinya Yokomizo, Megi Maci, April M. Stafford, Morgan R. Miller, Stephen J. Perle, Shuzo Inagaki, Shusaku Takahashi, Heather Brown‐Harding, Linda Liang, Alex Lovely, Moustafa Algamal, Rebecca L. Gillani, Theodore J. Zwang, Douglas Richardson, Janice R. Naegele, Daniel Vogt, Ksenia V. Kastanenka   +16 more
wiley   +1 more source

Deletion of Murine APP Aggravates Tau and Amyloid Pathologies in the 5xFADXTg30 Alzheimer’s Disease Model

Biomolecules
Alzheimer’s disease is characterized by two key neuropathological lesions: amyloid plaques composed of amyloid β and neurofibrillary tangles formed by hyperphosphorylated tau.
Kunie Ando, Andreea-Claudia Kosa, Yasmina Mehadji, Hinde Lasri, Lidia Lopez-Gutierrez, Carolina Quintanilla-Sánchez, Emmanuel Aydin, Emilie Doeraene, Alain Wathelet-Depauw, Siranjeevi Nagaraj, Jean-Pierre Brion, Karelle Leroy   +11 more
doaj   +1 more source

Beneficial Effect of a Selective Adenosine A2A Receptor Antagonist in the APPswe/PS1dE9 Mouse Model of Alzheimer’s Disease

Frontiers in Molecular Neuroscience, 2018
Consumption of caffeine, a non-selective adenosine A2A receptor (A2AR) antagonist, reduces the risk of developing Alzheimer’s disease (AD) and mitigates both amyloid and Tau lesions in transgenic mouse models of the disease.
Emilie Faivre, Joana E. Coelho, Katja Zornbach, Enas Malik, Younis Baqi, Younis Baqi, Marion Schneider, Lucrezia Cellai, Kevin Carvalho, Shéhérazade Sebda, Martin Figeac, Sabiha Eddarkaoui, Raphaëlle Caillierez, Yijuang Chern, Michael Heneka, Michael Heneka, Nicolas Sergeant, Christa E. Müller, Annett Halle, Annett Halle, Luc Buée, Luisa V. Lopes, David Blum   +22 more
doaj   +1 more source

Dysregulation of microtubule stability impairs morphofunctional connectivity in primary neuronal networks [PDF]

, 2017
Functionally related neurons assemble into connected networks that process and transmit electrochemical information. To do this in a coordinated manner, the number and strength of synaptic connections is tightly regulated.
Jacobine Kuijlaars, Jan R. Detrez, Jean-Pierre Timmermans, Marlies Verschuuren, Peter Verstraelen, Rony Nuydens, Winnok H. De Vos, Winnok H. De Vos   +7 more
core   +2 more sources

Olfactory‐to‐Entorhinal Network Dysrhythmias Drive Parkinson's Cognitive Impairment Through Frequency‐Specific Oscillatory Decoupling

Advanced Science, EarlyView.
Wang et al reveal that in the olfactory system, the selective impairment of gamma‐driven Barcode features underlying early olfactory deficits, while the selective impairment of theta‐driven Barcode features underlying later cognitive deficits, further establishing cross‐network gamma oscillations in the early stage as a biomarker of later cognitive ...
Shuaishuai Wang, Zhishen Cai, Xingfeng Mao, Yixuan Zhang, Yunlong Pan, Jiawen Cheng, Xuechun Wang, Hengyi Song, Sasaki Takuya, Ming Lu, Gang Hu, Xiuxiu Liu, Yingmei Lu, Feng Han   +13 more
wiley   +1 more source

Calcium in the initiation, progression and as an effector of Alzheimer's disease pathology. [PDF]

, 2009
The cause(s) of sporadic Alzheimer's disease (sAD) are complex and currently poorly understood. They likely result from a combination of genetic, environmental, proteomic and lipidomic factors that crucially occur only in the aged brain.
Green, Kim N
core   +1 more source

Clinical Spectrum of Tauopathies

Frontiers in Neurology, 2022
Tauopathies are both clinical and pathological heterogeneous disorders characterized by neuronal and/or glial accumulation of misfolded tau protein. It is now well understood that every pathologic tauopathy may present with various clinical phenotypes based on the primary site of involvement and the spread and distribution of the pathology in the ...
Nahid Olfati, Nahid Olfati, Ali Shoeibi, Irene Litvan   +3 more
openaire   +5 more sources