Results 1 to 10 of about 24,996 (165)

Amesia nigricolor, a novel endophyte of Encephalartos bubalinus, exhibiting a robust taxol biosynthetic stability: chemical characterization and biological activities [PDF]

Microbial Cell Factories
Diminishing the productivity of Taxol by the potential fungi with storage is the key hurdle that impedes their applications to be an industrial platform for Taxol production.
Asmaa Gamal, Ashraf S. A. El-Sayed, Eman Fikry, Nora Tawfeek, Azza M. El-Shafae, Maher M. El-Domiaty   +5 more
doaj   +2 more sources

Two-Phase Synthesis of Taxol

Journal of the American Chemical Society, 2020
Taxol® is widely regarded as amongst the most famed natural isolates ever discovered, and has been the subject of innumerable studies in both basic and applied science. Its documented success as an anticancer agent, coupled with early concerns over supply, stimulated a furious worldwide effort from chemists to provide a solution for its preparation ...
Yuzuru Kanda, Hugh Nakamura, Shigenobu Umemiya   +2 more
exaly   +5 more sources

Human mesenchymal stroma/stem-like cell-derived taxol-loaded EVs/exosomes transfer anti-tumor microRNA signatures and express enhanced SDF-1-mediated tumor tropism [PDF]

Cell Communication and Signaling
Background The release of extracellular vesicles (EVs) including exosomes from human mesenchymal stroma/stem-like cells (MSC) represents valuable cell-free carriers for the delivery of regenerative and medicinal compounds.
Ralf Hass, Juliane von der Ohe, Tianjiao Luo   +2 more
doaj   +2 more sources

Transcriptome-based signature predicts the effect of taxol in serous ovarian cancer. [PDF]

PLoS ONE, 2018
Taxol is a widely used chemotherapy drug used clinically for ovarian cancer, although the response to Taxol among individuals varies due to the heterogeneity among ovarian cancer patients. In this work, we analyzed differences in the prognostic effect of
Shunyu Hou, Jianrong Dai
doaj   +1 more source

The Taxol Pharmacophore and the T-Taxol Bridging Principle [PDF]

Cell Cycle, 2004
Different approaches to developing an accurate model of the binding conformation of paclitaxel (Taxol, PTX) on beta-tubulin are discussed. Electron crystallography, molecular modeling, NMR and synthetic studies all point to the T-Taxol conformation as the bioactive form.
Susan Bane, David G. I. Kingston, James P. Snyder   +2 more
openaire   +3 more sources

Taxol acts differently on different tubulin isotypes

Communications Biology, 2023
Taxol is a small molecule effector that allosterically locks tubulin into the microtubule lattice. We show here that taxol has different effects on different single-isotype microtubule lattices.
Yean Ming Chew, Robert A. Cross
doaj   +1 more source

Detection, Purification and Elucidation of Chemical Structure and Antiproliferative Activity of Taxol Produced by Penicillium chrysogenum

Molecules, 2020
Penicillium chrysogenum has been reported as a potent taxol producer based on quantitative analysis by TLC and HPLC. The biosynthetic potency of taxol has been validated from PCR detection of rate-limiting genes of taxol synthesis such as ...
Ashraf El-Sayed, Gamal Enan, Abdul-Raouf Al-Mohammadi, Ahmed H. Moustafa, Nashwa El-Gazzar   +4 more
doaj   +1 more source

Conjugation of Aspergillus flavipes Taxol with Porphyrin Increases the Anticancer Activity of Taxol and Ameliorates Its Cytotoxic Effects

Molecules, 2020
Taxol is one of the potential anticancer drugs; however, the yield of Taxol and its cytotoxicity are common challenges. Thus, manipulating the Taxol biosynthetic pathway from endophytic fungi, in addition to chemical modification with biocompatible ...
Ashraf S. A. El-Sayed, Maher Fathalla, Marwa A. Yassin, Nabila Zein, Shaima Morsy, Mahmoud Sitohy, Basel Sitohy   +6 more
doaj   +1 more source

Warburg effect in chemosensitivity: Targeting lactate dehydrogenase-A re-sensitizes Taxol-resistant cancer cells to Taxol

Molecular Cancer, 2010
Background Taxol is one of the most effective chemotherapeutic agents for the treatment of patients with breast cancer. Despite impressive clinical responses initially, the majority of patients eventually develop resistance to Taxol.
Riker Adam I, Fodstad Oystein, Liu Zixing, Liu Hao, Ding Yan, Zhao Yuhua, Zhou Ming, Kamarajugadda Sushama, Lu Jianrong, Owen Laurie B, Ledoux Susan P, Tan Ming   +11 more
doaj   +1 more source

Local Delivery of Taxol From FGL-Functionalized Self-Assembling Peptide Nanofiber Scaffold Promotes Recovery After Spinal Cord Injury

Frontiers in Cell and Developmental Biology, 2020
Taxol has been clinically approved as an antitumor drug, and it exerts its antitumor effect through the excessive stabilization of microtubules in cancer cells.
Zhiyong Xiao, Yingtao Yao, Yingtao Yao, Zhiyu Wang, Qing Tian, Jiedong Wang, Li Gu, Bo Li, Qixin Zheng, Yongchao Wu   +9 more
doaj   +1 more source