Human GM3 Synthase Attenuates Taxol-Triggered Apoptosis Associated with Downregulation of Caspase-3 in Ovarian Cancer Cells [PDF]
, 2012 BACKGROUND: Taxol (paclitaxel) inhibits proliferation and induces apoptosis in a variety of cancer cells, but it also upregulates cytoprotective proteins and/or pathways that compromise its therapeutic efficacy.
Bijangi-Vishehsaraei, Khadijeh +3 more
core +1 more source
Biotechnology Reports, 2019 Taxol® (generic name Paclitaxel) is a chemotherapeutic drug, effective against head, neck, breast, lung, bladder, ovary, and cervix cancers. Rising demands in chemotherapy and limited supply of natural taxol have ultimately increased the cost of the drug.
Pradeep Kumar +6 more
doaj +1 more source
Baseline survey of root-associated microbes of Taxus chinensis (Pilger) Rehd. [PDF]
PLoS ONE, 2015 Taxol (paclitaxel) a diterpenoid is one of the most effective anticancer drugs identified. Biosynthesis of taxol was considered restricted to the Taxus genera until Stierle et al.
Qian Zhang +7 more
doaj +1 more source
miR-218 targets survivin and regulates resistance to chemotherapeutics in breast cancer [PDF]
, 2015 Multidrug resistance (MDR) remains one of the most significant obstacles in breast cancer treatment, and this process often involves dysregulation of a great number of microRNAs (miRNAs).
Hu, Y, Xu, K, Yagüe, E
core +1 more source
Length-dependent disassembly maintains four different flagellar lengths in Giardia. [PDF]
, 2019 With eight flagella of four different lengths, the parasitic protist Giardia is an ideal model to evaluate flagellar assembly and length regulation. To determine how four different flagellar lengths are maintained, we used live-cell quantitative imaging ...
Aurrecoechea +69 more
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Sulfo-SMCC Prevents Annealing of Taxol-Stabilized Microtubules In Vitro [PDF]
, 2016 Microtubule structure and functions have been widely studied in vitro and in cells. Research has shown that cysteines on tubulin play a crucial role in the polymerization of microtubules.
Prabhune, Meenakshi +3 more
core +7 more sources
Molecules, 2021 Taxol is one of the most effective anticancer drugs in the world that is widely used in the treatments of breast, lung and ovarian cancer. The elucidation of the taxol biosynthetic pathway is the key to solve the problem of taxol supply.
Tao Wang +6 more
doaj +1 more source
A permeabilized cell model for studying cell division: a comparison of anaphase chromosome movement and cleavage furrow constriction in lysed PtK1 cells. [PDF]
, 1981 After lysis in a Brij 58-polyethylene glycol medium, PtK1 cells are permeable to small molecules, such as erythrosin B, and to proteins, such as rhodamine-labeled FAB, myosin subfragment-1, and tubulin.
CANDE, W. Zacheus +2 more
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A systematic review of platinum and taxane resistance from bench to clinic: an inverse relationship [PDF]
, 2007 We undertook a systematic review of the pre-clinical and clinical literature for studies investigating the relationship between platinum and taxane resistance.
Davey, Ross +2 more
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Lysophosphatidate induces chemo-resistance by releasing breast cancer cells from taxol-induced mitotic arrest. [PDF]
PLoS ONE, 2011 Taxol is a microtubule stabilizing agent that arrests cells in mitosis leading to cell death. Taxol is widely used to treat breast cancer, but resistance occurs in 25-69% of patients and it is vital to understand how Taxol resistance develops to improve ...
Nasser Samadi +4 more
doaj +1 more source